CAS 111-92-2 MFCD00009429-Dibutylamine 二丁胺 TAO{mole}

Dibutylamine 二丁胺

CAS 111-92-2 MFCD00009429

化学结构图

SMILES: CCCCNCCCC

化学属性

Mol. Formula	C8H19N
Mol. Weight	129.24
Density	0.76
Refractive index	1.4170 to 1.4190
Autoignition Point	594 °F
Vapor Density	4.46 (vs air)
Boiling Point	-
Vapor Pressure	1.9 mmHg ( 20 °C)
Melting Point	-62
Flash Point	41.11°C
TSCA	Yes
Solubility	微溶于水，溶于乙醇、乙醚。
pH	:A

别名和识别编码

Chemical Name	Dibutylamine
CAS Number	111-92-2
EC Number	203-921-8
Beilstein Registry Number	506001
MDL Number	-
Synonym	Dibutylamine di-n-butylamine dibutylamine dibutylamine hydrochloride dibutylamine phosphate (3:1) {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} dibutylamine phosphate (3:1) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} dibutylamine hydrochloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} dibutylamine
PubChem Substance ID	8148
Merck Number	3032
Reaxys-RN	506001
Chemical Name Translation	二丁胺
Wiswesser Line Notation	4M4
LabNetwork Molecule ID	LN00199518
InChI	InChI=1S/C8H19N/c1-3-5-7-9-8-6-4-2/h9H,3-8H2,1-2H3
Canonical SMILES	CCCCNCCCC

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产品应用

用于生产医药、农药、染料、矿物浮选剂、乳化剂以及精细化学品的中间体等。用作腐蚀称职制剂，橡胶促进剂，杀虫剂，阻聚剂等。

安全信息

Signal word Danger

GHS Symbol

WGK Germany1

Safety Statements

S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R10 Flammable 易燃
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
R23 Toxic by inhalation 吸入有毒
R34 Causes burns 会导致灼伤
R35 Causes severe burns 会导致严重灼伤

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P233 Keep container tightly closed. ?保持容器密闭。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P241+P242+P243
P242 Use only non-sparking tools. 只能使用无火花工具。
P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P312
P301+P316
P301+P317
P301+P330+P331
P301+P330+P331+P310
P302+P352
P302+P361+P354
P303+P361+P353
P303+P361+P353+P310+P363
P304+P312
P304+P340
P304+P340+P310
P305+P351+P338
P305+P351+P338+P310
P305+P354+P338
P307+P311
P308+P311
P308+P316
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P316
P317
P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P361+P364
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P370+P378
P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
P403+P233
P403+P235
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H226 Flammable liquid and vapour 易燃液体和蒸气
H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H302+H312+H332
H311 Toxic in contact with skin 皮肤接触中毒
H312 Harmful in contact with skin 皮肤接触有害
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H318 Causes serious eye damage 严重伤害眼睛
H330 Fatal if inhaled 吸入致命
H332 Harmful if inhaled 吸入有害
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSHR7780000

Packing GroupII

UN Number 2248 UN 2248 8/PG 2 UN2248

Hazard Codes 8 T Xn

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard Class8/3

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1010 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 10,61,1954

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 189 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RCBUAU Revista de Chimie (Bucharest).  (Rompresfilatelia, POB 12-201,
   Bucharest, Romania) V.1-    1950-  Volume(issue)/page/year: 36,667,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperito

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 40(11),21,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 40(11),21,1975

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 200 mg/L/48H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,337,1977

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 5 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,19,1977

Restrict 危险品

其他信息

上游原料:氨 --> 正丁醇 --> 4-氯苯甲醛 --> 溴丁烷 --> 正丁胺 --> 氰氨化钙 --> 三正丁胺 --> 流量计 --> 戊腈 --> 酸性白土
图谱信息:二正丁胺(111-92-2)质谱(MS) 二正丁胺(111-92-2)核磁图( 13 CNMR) 二正丁胺(111-92-2)红外图谱(IR2) 二正丁胺(111-92-2)红外图谱(IR1) 二正丁胺(111-92-2)核磁图( 1 HNMR)
急性毒性:口服- 大鼠 LD50: 189 毫克/ 公斤; 口服- 小鼠 LD50: 290 毫克/ 公斤
用途三:二正丁胺是一种有机合成原料，在农药上可用来合成丁硫克百威，还可用于染料、橡胶硫化促进剂(BZTP)、防老化剂(NBC)、POP聚合催化剂、抗腐蚀剂、药物以及油品添加剂二丁基二硫代氨基甲酸盐(钼、铅、锑、锌)的生产。
蒸气压:1.9 mm Hg ( 20 °C)
毒性分级:高毒
二正丁胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80044027 二正丁胺 250ml 28.3元 2011/04/16 D0218 二丁胺 Dibutylamine 25ML 155元 2011/04/16 D0218 二丁胺 Dibutylamine 500ML 275元
有氨的气味。能与水、乙醇、乙醚相混溶，溶于丙酮、乙酸乙酯、石油醚。
下游产品:正丁胺 --> 三正丁胺 --> 6-溴-3,4-二氢-3-硝基-2H-苯并吡喃 --> 丁硫克百威 --> 2-(甲氧基甲基)丙烯醛 --> 2-乙基丙烯醛 --> 二丁基二硫代氨基甲酸镍 --> 双二正丁胺基二硫物 --> N,N-二丁基乙酰胺 --> 3-(二丁胺)丙胺 --> 2-N-二丁氨基乙醇 --> 二丁基二硫代氨基甲酸锌
方法一:二正丁胺有两种生产方法。正丁醇法由正丁醇与氨作用而得。反应方程式如下：n-C 4 H 9 OH+NH 3 +H 2 →n-C 4 H 9 NH 2 +(n-C 4 H 9 ) 2 NH+(n-C 4 H 9 ) 3 N 工艺过程为：将正丁醇、氨气、氢气经流量计控制，按配比通入不锈钢反应塔，塔内填充铜镍酸性白土催化剂，反应温度在200℃左右。反应结束后将反应气体冷凝，得到的粗产品含一丁胺2％～4.82％、二丁胺17％～26％、三丁胺31％～61％，通过精馏分离可得一丁胺、二丁胺和三丁胺。石灰氮(氰氨化钙)法反应方程式如下：CaCN[NaOH]→Na 2 NCN[C 4 H 9 Br]→(C 4 H 9 ) 2 NCN[H 2 O]→[H 2 SO 4 ](C 4 H 9 ) 2 NH 工艺过程为：将石灰氮悬浮在冰水中，慢慢加入冷却的氢氧化钠溶液，温度保持在25℃以下，剧烈搅拌1h，得到氰氨化钠溶液。向此溶液中加入溴丁烷乙醇溶液，搅拌回流2.5h，然后进行蒸馏，将剩余物冷却吸滤，滤饼用乙醇洗涤，将滤液和洗液合并，用苯萃
用途四:作用机合成中间体。用于染料、橡胶硫化促进剂、抗腐蚀剂、药物、油品添加剂的生产。该品有毒，小鼠口服LD50550mg/kg。用二丁胺生产二硫代氨基甲酸盐类促进剂，例如，二丁基二硫代氨基甲酸锌（促进剂BZ）是由促进剂TP与ZnCI2经置换而得的。而促进剂TP（二丁基二硫代氨基甲酸钠）是由二丁胺与二硫化碳和氢氧化钠反应得到的。这类产品属超促进剂，因焦烧时间太短，一般用于胶乳生产。促进剂TP与NiSO4反应可得防老剂NBC。该品在天然橡胶、丁苯、氯丁等合成橡胶中防护热、臭氧、天候的老化。二丁基二硫代氨基甲酸盐（钼、铅、锑），例如二丁铅。用作石油添加剂，有抗氧化、抗磨、抗极压的功能。促进剂TP用氧化剂铁氰化钾在低于0℃条件下氧化而生成二硫化四丁基秋兰姆。也是天然橡胶及合成橡胶的超促进剂，亦可作硫化剂。
用途一:用于石油添加剂、橡胶促进剂、矿物浮选剂、腐蚀抑制剂
Acros Organics:二丁基胺 Di-n-butylamine, 99%(111-92-2)
储运特性:包装完整、轻装轻卸; 库房通风、远离明火、高温、与氧化剂、酸分开存放
刺激数据:皮肤- 兔子 10 毫克/ 24小时重度; 眼- 兔子 250 微克重度