Methanone, (2-​hydroxy-​4-​methoxyphenyl)​phenyl- 2-羟基-4-甲氧基二苯甲酮

CAS 131-57-7 MFCD00008387

化学结构图

131-57-7
SMILES: COc1ccc(C(=O)c2ccccc2)c(O)c1

化学属性

Mol. FormulaC14H12O3
Mol. Weight228
Boiling Point150-160
Melting Point62-64
Density0.8
Flash Point216°(420°F)
TSCAYes
Solubility<0.1 G/100 ML AT 20 ºC

别名和识别编码

Chemical NameMethanone, (2-​hydroxy-​4-​methoxyphenyl)​phenyl-
Synonym (2-Hydroxy-4-methoxyphenyl)phenylmethanone (2-hydroxy-4-m (2-羟基-4-甲氧苯基)(苯基)甲酮 (2-羟基-4-甲氧苯基)苯基酮 2-Hydroxy-4-methoxy-benzophenone 2-Hydroxy-4-methoxybenzophenone; 2-Benzoyl-5-methoxyphenol; 4-Methoxy-2-hydroxybenzophenone; HMB 2-Hydroxy-4-methoxyphenyl-phenylmethanon 2-羟基-4-甲氧基二苯甲酮/二苯酮-3 4-Met Aduvex 24 Advastab 45 BENZOPHENONE-3 Cyasorb UV 9 Jeescreen Benzophenone 3 Neo Heliopan BB Onzone Oxybenzon Oxybenzone Sumisorb 110 Sunscreen UV 15 Syntase 62 UV-ABSORBER BAYER 325 Uvistat 24 advastab45 {} {} { {} {} {Chemica {} {} {Chemicalb {} {} {uni_hamburg} 氧苯酮 紫外线吸收剂 UV-9 羟苯甲酮
CAS Number131-57-7
PubChem Substance ID87570693
EC Number205-031-5
Beilstein Registry Number1913145
MDL NumberMFCD00008387
Reaxys-RN1913145
Merck Number6954
Alfabeta NameHYDROXYMETHOXYPHENYLPHENYLMETHANONE 24(())---
Chemical Name Translation2-羟基-4-甲氧基二苯甲酮
Wiswesser Line Notation1OR CQ DVR
LabNetwork Molecule IDLN00179297
InChIInChI=1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3
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分类

  • Aldehydes and Ketones, Alphabetical, Analytical Standards,
  • {SNA} Analytical Reagents, Analytical/Chromatography, Building Blocks, C13 to C14, Carbonyl Compounds, Chemical Synthesis, Gravimetric Reagents, Ketones, Organic Building Blocks
  • {SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards N - O, 分析/色谱
  • {SNA} Aldehydes and Ketones, Alphabetical,
  • {SNA} Building Blocks, C13 to C14, Carbonyl Compounds, Chemical Synthesis, Gravimetric Reagents, Ketones, Organic Building Blocks, 分析/色谱,

产品应用

  • Cu(II)重量法测定试剂

相关文献及参考

  • [2]. DiNardo JC, et al. Can oxybenzone cause Hirschsprung's disease?. Reprod Toxicol. 2019;86:98-100.
  • [3]. Wnuk A, et al. Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells. Mol Neurobiol. 2018;55(6):5059-5074.
  • Merck: 14,6954
  • Merck: 14,6954 Beilstein:8,312
  • Short: EINECS
  • Short: IV/20B
  • [1]. Wnuk A, et al. Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons. J Steroid Biochem Mol Biol. 2018;182:106-118.
  • [1]. Wnuk A, et al. Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons. J Steroid Biochem Mol Biol. 2018;182:106-118.
  • [2]. DiNardo JC, et al. Can oxybenzone cause Hirschsprung's disease?. Reprod Toxicol. 2019;86:98-100.
  • [3]

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
RTECSDJ1575000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
UN Number 3077
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Warnings IRRITANT
Packing GroupIII
Hazard Class9 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 2(5),35,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 9(Suppl
   9),1,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1268 gm/kg
SEX/DURATION            : male 13 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1687 gm/kg
SEX/DURATION            : female 13 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Seri

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 297 gm/kg
SEX/DURATION            : female 13 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NIH-92-3344

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 45 gm/kg
SEX/DURATION            : female 90 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 10,41,1972

其他信息

  • 外观:白色或浅黄绿色结晶粉末.
  • Alfa Aesar:2-羟基-4-甲氧基二苯甲酮,98+% 2-Hydroxy-4-methoxybenzophenone, 98+%(131-57-7)
  • 下游产品:新型光敏聚酰亚胺/SIO2杂化材料
  • 用途二:是一种广谱紫外线吸收剂,具有吸收率高、无毒、无致畸作用,对光、热稳定性好等优点,它同时可以吸收 UV-A 和 UV-B ,是美国 FDA 批准的Ⅰ类防晒剂,在美国和欧洲使用频率较高,广泛用于防晒膏、霜、蜜、乳液、油等防晒化妆品中,也可作为由光敏性而变色的产品的抗变色剂,另外由于它
  • 易溶于大多数有机溶剂，不溶于水。
  • MSDS 信息:2-Hydroxy-4-methoxybenzophenone(131-57-7).msds
  • 用途一:二苯甲酮类紫外线吸收剂，是聚乙烯等 合成塑料的优良稳定剂，用量为0.5～1.5%，亦可用于油漆、颜料、涂料工业、精白腊及 日用化妆品中。
  • 上游原料:硫酸二甲酯 --> 苯甲酰氯
  • 紫外线吸收剂UV-9作用:紫外线吸收剂UV-9为浅黄色或白色结晶粉末，又名防晒剂2号、BP-3，适用于聚氯乙烯、聚偏二氯乙烯、聚甲基丙烯酸甲酯、不饱和聚酯、ABS树脂和纤维素树脂等多种塑料，最大吸收波长范围为280-340纳米，一般用量为0.1-1.5%，热稳定性好，在200℃时不分解。本品几乎不吸收可见光，故适用于浅色透明制品。本品还可用于油漆和合成橡胶。为广谱紫外线吸收剂,具有吸收率高、无毒、无致畸作用,对光、热稳定性好等优点,紫外线吸收剂UV-9同时可以吸收UV-A和UV-B,是美国FDA批准的Ⅰ类防晒剂，美欧国家使用频率较高,UV-9广泛用于防晒膏、霜、蜜、乳液、油等防晒化妆品中,也可作为由光敏性而变色的产品的抗变色剂,另外由于UV-9与许多塑料、树脂具有良好的兼容性,通常用于PVC和不饱和聚脂等许多领域.
  • 用途三:用于塑料、化纤、油漆及石油制品中，特别适用于浅色透明制品
  • 紫外线吸收剂:紫外线吸收剂是一种光稳定剂，能吸收阳光及荧光光源中的紫外线部分，而本身又不发生变化。保护塑料免受由紫外线照射导致的光氧化降解，因而使产品使用的寿命大为延长。塑料和其他高分子材料在日光和荧光下，因紫外线的作用，产生自动氧化反应，导致聚合物的降解而劣化，使外观及机械性能变坏。加入紫外线吸收剂后可选择性地吸收这种高能量的紫外线，使之变成无害的能量而释放或消耗。 聚合物的种类不同，使其劣化的紫外线波长也不相同，不同的紫外线吸收剂可吸收不同波长的紫外线，使用时，应根据聚合物的种类选择紫外线吸收剂。 紫外线吸收剂应该具备以下条件：①可强烈地吸收紫外线（尤其是波长为290-400nm）；②热稳定性好，即使在加工中也不会因热而变化，热挥发性小；③化学稳定性好，不与制品中材料组分发生不利反应；④混溶性好，可均匀地分散在材料中，不喷霜，不渗出；⑤吸收剂本身的光化学稳定性好，不分解，不变色；⑥无色、无毒、无臭；⑦耐浸洗；⑧价廉、易得。紫外线吸收剂按化学结构可分为以下几类：水杨酸酯类、苯酮类、苯并三唑类、取代丙烯腈类、三嗪类和其他类。 紫外线吸收剂用于塑料、涂料、染料、汽车挡风玻璃、化妆品、药物、防晒剂等。
  • 紫外线吸收剂UV-9生产工艺的改进:用混和酸作催化剂,三氯甲基苯和间苯二酚在水相中缩合成中间体2,4-二羟基二苯基甲酮.然后在相转移催化剂的作用
  • 紫外线吸收剂 UV-9价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 H0266 2-羟基-4-甲氧基二苯甲酮 2-Hydroxy-4-methoxybenzophenone 500G 927元 2014/06/02 H0266 2-
  • 常见的紫外线吸收剂:水杨酯苯酯(成分:邻羟基苯甲酸苯酯),紫外线吸收剂UV-P(成分:邻硝基苯胺、对甲苯酚的反应产物),紫外线吸收剂UV-O(成分:2，4-二羟基二苯甲酮),紫外线吸收剂UV-9(成分:2-羟基-4-甲氧基二苯甲酮),紫外线吸收剂UV-531(成分:2-羟基-4-正辛氧基二苯甲酮),紫外线吸收剂UVP-327 (成分:2-（2’-羟基-3’，5’-二叔苯基）-5-氯化苯并三唑),紫外线吸收剂RMB (成分:单苯甲酸间苯二酚酯),光稳定剂AM-101(成分:2，2’-硫代双（4

系列性分类

  1. Chemical Synthesis 化学合成
  2. Specialty Synthesis 特殊合成技术
  3. Ionic Liquids - Specialty Synthesis
  4. Pyridinium - Ionic Liquids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones - Carbonyl Compounds
  6. C13 to C14 - Ketones
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Substance Classification - Phytopharma Standards
  7. Aldehydes and Ketones - Substance Classification
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Alphabetical - Phytopharma Standards
  7. N - R - Alphabetical
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Aromatic Ketones
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Ketones 酮
  6. C11 to C12
  1. Medical Research Areas
  2. Metabolism
  3. RAR/RXR  (维甲酸受体)

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