CAS 2524-03-0 MFCD00008353-Dimethyl chlorothiophosphate 二甲基硫代磷酰氯 TAO{mole}

Dimethyl chlorothiophosphate 二甲基硫代磷酰氯

CAS 2524-03-0 MFCD00008353

化学结构图

SMILES: COP(=S)(Cl)OC

化学属性

Mol. Formula	C2H6ClO2PS
Mol. Weight	160.56
Refractive index	n20/D 1.482(lit.)
Boiling Point	66-67 °C/16 mmHg(lit.)
Density	1.322 g/mL at 25 °C(lit.)
Flash Point	93 ºC
Solubility	SLOWLY HYDROLYZES
Vapor Pressure	0.67 psi ( 20 °C)

别名和识别编码

Chemical Name	Phosphorochloridothioic acid, O,O-dimethyl ester
Synonym	dimethyl chlorothiophosp O,O-DIMETHYL PHOSPHOROCHLORIDOTHIOATE { DIMETHYL CHLOROTHIOPHOSPHATE DIMETHYLTHIOPHOSPHORIL CHLORIDE O O,O-Dimethyl thionophosphorochloridate O,O-Dimethylchlorthiophosphat O,O-Dimethyl c O,O-Dimethyl-thiophosphorsäurechlorid O,O-DIMETHYLPHOSPHOROCHLOROTHIOATE dimethyl phosphorochloridothionate O,O-Dimethyl phosphorochlorothioate Phosphorochloridothioic acid O,O-dimethyl ester (CH3O)2P(S)Cl {Chemi {Ch O,O dimethyl phosphorochloridothioate O,O-Dimethyl chlorothiophosphate {uni_hambur Dimethyl thionophosphorochloridate 二甲基硫代磷酰氯 Dimethylchlorthiofosfat Dimethyl chlorothion Dimethyl chlorothiophosphonate O,O-Dimethylphosphorochloridothioate Thiophosphorsäure-O,O-dimethylesterchlorid {u thiophosphorochloridic acid O,O'-dimethyl ester Phosphonothioic acid, chloro-, O,O-dimethyl ester O,O-Dimethyl thionophosphoryl chloride DIMETHYL PHOSPHOROCHLORIDOTHIOATE 氯代亚磷酸二甲酯 Dimethoxythiophosphoryl chloride O,O-Dimethylester kyseliny chlorthiofosforecne O,O-Dimethyl thiophosphoric acid chloride DIMETHYLPHOSPHOROCHLOROTHIOATE Dimethoxythiophosphonyl chloride Phosphorochloridothioic acid, O,O dimethyl ester O,O'-Dimethyl phosphonochloridothioate Dimethyl phosphorochlorothioate AURORA KA-1651 {Chemicalbook DMPCT Chlorodimethoxyphosphine sulfide O,O dimethyl chlorophosphorothioate METHYL PHOSPHOROCHLORIDOTHIOATE Methyl PCT
CAS Number	2524-03-0
PubChem Substance ID	17304
EC Number	219-754-9
MDL Number	MFCD00008353
Chemical Name Translation	二甲基硫代磷酰氯
Wiswesser Line Notation	SPGO1&O1
Beilstein Registry Number	0471300
InChI	InChI=1S/C2H6ClO2PS/c1-4-6(3,7)5-2/h1-2H3

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安全信息

GHS Symbol

WGK Germany3

Hazard Codes T

Hazard statements

H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H331 Toxic if inhaled 吸入中毒
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSTD1830000

Precautionary statements

P301+P310
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338

Signal word Danger

Safety Statements

S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R34 Causes burns 会导致灼伤
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
R23 Toxic by inhalation 吸入有毒

UN Number 2267 UN 2267 6.1/PG 2

Packing GroupII

Hazard Class6.1(a)

Restrict 剧毒化学品

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,56,1982

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 316 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
   Liver - other changes
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0536768

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0536768

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 340 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 37500 ug/kg/5D (Continuous)
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0381-0387

其他信息

用途二:该品为农药中间体，可用于生产杀暝松、杀暝晴、1605、甲基1605、甲胺磷和乙酰甲胺磷等。该品具有有机磷农药的毒性，对眼、粘膜及皮肤有刺激性，吸入或经皮肤吸收会引起中毒。小白鼠口服LD50为450mg/kg。
方法一:甲基氯化物的合成主要有两条路线。如以三氯硫磷为原料，则又分甲醇钠法、醇碱两步法、水碱一步法及液碱两步法等；若以五硫化二磷为原料，则先与甲醇反应制成二硫代磷酸甲酯，再经氯化而成，氯化剂可用液氯、氯化亚砜、三氯化磷和五氯化磷等。国内工业生产主要采用三氯硫磷路线，过去多采用醇碱两步法和水碱一步法，现在采用的是液碱两步法。将三氯硫磷先冷却至-7℃，加甲醇反应4h，控制反应温度在0℃以下，产物经水洗即得O-甲基磷酰二氯(简称二氯)。将二氯与甲醇一次投入反应锅，搅拌并冷却至-5℃，滴加工业液碱(30%)，控制反应温度在0℃以下，加完后搅拌15min，产物经水洗，静置分出一氯化物，含量>;90％，二氯化物含量<;2％，三甲酯含量<;8％，收率为80％～85％(以三氯硫磷计)。本法克服了醇碱法中固碱来源困难、醇碱配制劳动强度大等缺点，但收率和含量仍偏低。国外曾有报道，可以得到较高收率、含量的甲基氯化物，如3mol甲醇和1mol三氯硫磷在0～10℃反应，可以几乎以定量的收率和接近100％的纯度得到甲基二氯化物。将反应混合物用水急冷，分出有机相，再用3mol甲醇与1mol甲基二氯化物在有缚酸剂存在下于0～20℃反应，用水稀释后分出有机相，即得纯度为96％以上的甲基氯化物，收率高于95％。目前国内也有采用五硫化二磷法制备高质量的甲基氯化物。即以催化法新工艺制得的甲基硫化物为原料，在一定的反应条件下，得到甲基氯化物粗品含量平均为64.69％，收率平均为96.05％。将所得的副产物硫化钠溶液用于精制粗品甲基氯化物，解决了硫磺发黏、结块等关键问题，其中使用助催化剂是本工艺的技术关键。所得精制氯化物为清澈油状物，平均含量为97.89％，平均收率(以硫化物计)为97.87％。回收硫磺为砂状结晶，松散不黏，易于过滤。
蒸气压:0.67 psi ( 20 °C)
MOL 文件:2524-03-0.mol
方法二:由甲醇与三氯硫磷反应生成O-甲基硫代磷酰氯，然后再与甲醇进一步反应而得。将173kg三氯硫磷投入反应锅中，搅拌冷却至-15℃，缓缓加入甲醇，温度控制在-5℃左右，加完161.5kg甲醇后，再搅拌反应10min。将反应物放在0℃的冷水中洗涤、分层，下层为O-甲基硫代磷酰氯（即二氯化物）。按二氯化物量的1.08倍称取固体氢氧化钠，溶解在4倍的重量的甲醇中配成醇碱液。将其冷至-15℃，滴加入二氯化物中，控制温度在-5℃左右。加毕，将料液吸入水洗锅中，加1%的盐酸水洗涤，静置分层，下层即为O,O-二甲基硫代磷酰氯。
Acros Organics:氯硫代磷酸二甲酯 Dimethylchlorothiophosphate,97%(2524-03-0)
图谱信息:二甲基硫代磷酰氯(2524-03-0)核磁图( 1 HNMR) 二甲基硫代磷酰氯(2524-03-0)质谱(MS) 二甲基硫代磷酰氯(2524-03-0)红外图谱(IR1) 二甲基硫代磷酰氯(2524-03-0)核磁图( 13 CNMR)
上游原料:氢氧化钠 --> 五氯化磷 --> 五硫化二磷 --> 二甲基硫 --> 硫代磷酰氯 --> 氯化钴 --> 固体氢氧化钠 --> 二甲基硫代磷酰氯 --> 甲基二氯化物
用途一:O，O-二甲基硫代磷酰氯简称甲基氯化物，在农药合成上应用广泛，可用于生产有机磷杀虫剂杀螟硫磷、甲基对硫磷、倍硫磷、甲基毒死蜱、甲
二甲基硫代磷酰氯价格(试剂级):更新日期产品编号产品名称包装价格 2010/06/21 116130050 二甲基硫代磷酰氯 Dimethyl chlorothiophosphate 97% 5 GR 225元 2010/06/21 116131000 二甲基硫代磷酰氯 Dimethyl chlorothiophosphate 97% 100 GR 231元 2010/06/21 116135000 二甲基硫代磷酰氯 Dimethyl chlorothiophosphate 97% 500 GR 781元
Sigma Aldrich:2524-03-0(sigmaaldrich)