CAS 124-09-4 MFCD00008243-1,6-Diaminohexane 1,6-己烷二胺 TAO{mole}

1,6-Diaminohexane 1,6-己烷二胺

CAS 124-09-4 MFCD00008243

化学结构图

SMILES: NCCCCCCN

化学属性

Mol. Formula	C6H16N2
Mol. Weight	116.20
Refractive index	n20/D 1.439(lit.)
Boiling Point	205°C(lit.)
Density	0.89 g/mL at 25 °C(lit.)
Melting Point	40.0 to 44.0 deg-C
Flash Point	93.89°C
TSCA	Yes
Vapor Density	4 (vs air)
Solubility	490 G/L (20 ºC)
Stability	对空气及湿度敏感

别名和识别编码

Chemical Name	1,6-Diaminohexane
Synonym	1,6-Hexanediamine {LY} 1,6-Hexanediamine 1,6-Hexanediamine, 98+% 1,6-Hexanediamine,~99% 1,6-Hexylenediamime 1,6-Hexylenediamine 1,6-diamino-hexan 1,6-diaminohexamethylene 1,6-diaminohexane 1,6-diaminohexane dihydrochloride 1,6-diaminohexane dihydrochloride, 1-(11)C-labeled 1,6-diaminohexane dihydrofluoride 1,6-diaminohexane monohydrochloride 1,6-hexamethylenediamine 1,6-hexane diamine 1,6-hexanediamine NSC 9257 {} {LY} 1,6-Hexanediamine {} {} {LY} 1,6-Hexanediamine {} {} {} {LY} 1,6-Hexanediamine {} {} {} {} {LY} 1,6-Hexanediamine {} {} {} {} {} {} {} {} {} {} {LY} 1,6-Hexanediamine {} {} {} {} {} {} {LY} 1,6-Hexanediamine {} {} {} {} {} {} {} {LY} 1,6-Hexanediamine {} {} {} {} {} {} {} {} {LY} 1,6-Hexanediamine {} {} {} {} {} {} {} {} {} {LY} 1,6-Hexanediamine {} {} {} {} {} {}
CAS Number	124-09-4
PubChem Substance ID	16402
EC Number	204-679-6
Beilstein Registry Number	4,269
MDL Number	MFCD00008243
Reaxys-RN	1098307
Merck Number	4695
Chemical Name Translation	1,6-己烷二胺
Wiswesser Line Notation	Z6Z
LabNetwork Molecule ID	LN00193766
InChI	InChI=1S/C6H16N2/c7-5-3-1-2-4-6-8/h1-8H2
Canonical SMILES	NCCCCCCN

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品牌质保精细包装现货库存一流品牌服务

产品应用

有机合成，尼龙66中间体。

安全信息

GHS Symbol

WGK Germany1

Hazard Codes C

Hazard statements

H302 Harmful if swallowed 吞食有害
H302+H312
H312 Harmful in contact with skin 皮肤接触有害
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H318 Causes serious eye damage 严重伤害眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSMO1180000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P301+P312+P330
P301+P330+P331
P301+P330+P331+P310
P302+P352
P303+P361+
P303+P361+P353
P304+P340
P304+P340+P310
P305+
P305+P351+P338
P305+P351+P338+P310
P307+P311
P308+P311
P308+P313
P309+P311
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P333+P313
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

UN Number 2280

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服；

Risk Statements

R34 Causes burns 会导致灼伤
R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
R37 Irritating to respiratory system 刺激呼吸道

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Packing GroupIII

Hazard Class8

Warnings 危化品目录(2015) 危险化学品

{haz

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,74,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/y

TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >950 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-1090-0979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#02313

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 66500 mg/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   16,490,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - hepatobiliary system
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 7,259,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 77 gm/kg
SEX/DURATION            : multigeneration
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   16,490,1991

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 414 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotox

其他信息

{Chemicalbo
可燃性危险特性:可燃; 燃烧排放有毒氮氧化物烟雾
下游产品:
用途二:用作尼龙66、聚氨酯泡沫塑料的原料及环氧树脂固化剂
上游原料:镍 --> 硅凝胶 --> 硅藻土 --> 1,3-丁二烯 --> 己二酸 -->
1,6-已烷二胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80068818 1，6-己二胺;己烷二胺;六亚甲基二胺;1,6-二氨基己烷 500ml 46元 2011/04/16 D0095 1,6-己二胺 1,6-Diaminohexane 25G 150元 2011/04/16 D0095 1,6-己二胺 1,6-Diaminohexane 500G 42
类别:腐蚀物品
Sigma Aldrich:124-09-4(sigmaaldrich)
毒性分级:中毒
方法一:已二胺生产最初采用糠醛为原料，目前生产己二胺的工业方法较多，根据所用原料的不同有己二酸法、丁二烯法、丙烯腈法、己二醇法和己内酰胺法。其中己二酸法、丁二烯法和丙烯腈二聚法是经过中间物己二腈加氢生成己二胺，目前，几乎所有大规模生产己二胺的方法都是己二腈催化加氢法。1.工业上己二腈催化加氢有高压法和低压法两种。（1）高压法采用钴-铜催化剂，反应温度100-135℃，压力60-65MPa；也可采用铁催化剂，反应温度100-180℃，压剂可采用液氨，有时还加入芳烃（如甲苯）。己二胺的选择性约90-95%。生产中，将液态已腈、甲苯和氨与含氢氨以及少量的己二腈和甲苯的气体混合物通入装有钴-铜催化剂的反应器，生成的粗己二胺导出后，先使其与水进行共沸蒸馏，然后再通过几次真空蒸馏即得到适于制造尼龙66的高纯度产品。（2）低压法采用骨架镍、铁-镍或铬-镍催化剂，反应在氢氧化钠溶液中进行。反应温度约75℃，压力为3MPa，己二胺的选择性可达99%。为了防止催化剂中毒，对原料己二腈的纯度要求很高。2.以己二酸为原料的方法此法是将己二酸蒸气与过量的氨一起通过加热至340℃的硅胶等脱水催化剂，生成己二腈，然后在其中加入甲醇和液氨，用硅藻土镍为催化剂，在90-100℃下，以10.1325-20.265MPa氢进
防护措施:本品毒性较大，可引起神经系统、血管张力和造血功能的改变。吸入高浓度1，6-己二胺可引起剧烈头痛。皮肤接触高浓度1，6-己二胺，可致干性或湿性坏死，低浓度可引起皮炎和湿疹。溅入眼内引起眼睑红肿，结膜充血，甚至失明。对人眼睛的光敏阈为0.0027mg/m3，嗅觉阈为0.0033mg/m3。工作场所最高容许浓度1mg/m
用途四:有机合成，尼龙66中间体。
用途三:本品绝大部分用于合成尼龙66和610树脂，也用以合成聚氨酯树脂、离子交换树脂和亚己基二异氰酸酯，以及用作脲醛树脂、环氧树脂等的固化剂，有机交联剂等，还用作纺织和造纸工业的稳定剂、漂白剂，铝合金的抑制腐蚀剂和氯丁橡胶乳化剂等。已二胺与盐酸在28℃以下成盐得到1,6-已二胺盐酸盐（[6055-52-3]），可用来生产杀菌剂洗必泰乙酸盐。已二胺在粘接剂、航空涂料和橡胶硫化促进剂等生产中也有一些应用。
Alfa Aesar:1,6-二氨基己烷,98+% 1,6-Diaminohexane, 98+%(124-09-4)
1,6-已烷二胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80068818 1，6-己二胺;己烷二胺;六亚甲基二胺;1,6-二氨基己烷 500ml 46元 201
方法一:已二胺生产最初采用糠醛为原料，目前生产己二胺的工业方法较多，根据所用原料的不同有己二酸法、丁二烯法、丙烯腈法、己二醇法和己内酰胺法。其中己二酸法、丁二烯法和丙烯腈二聚法是经过中间物己二腈加氢生成己二胺，目前，几乎所有大规模生产己二胺的方法都是己二腈催化加氢法。1.工业上己二腈催化加氢有高压法和低压法两种。（1）高压法采用钴-铜催化剂，反应温度100-135℃，压力60-65MPa；也可采用铁催化剂，反应温度100-180℃，压剂可采用液氨，有时还加入芳烃（如甲苯）。己二胺的选择性约90-95%。生产中，将液态已腈、甲苯和氨与含氢氨以及少量的己二腈和甲苯的气体混合