CAS 60-23-1 MFCD00008196-Cysteamine 巯基乙胺 TAO{mole}

Cysteamine 巯基乙胺

CAS 60-23-1 MFCD00008196

化学结构图

SMILES: NCCS

化学属性

Mol. Formula	C2H7NS
Mol. Weight	77.15 g/mol
Density	1.422
Melting Point	94.0 to 99.0 deg-C
Stability	易吸潮,二氧化碳敏感
Solubility	易溶于水，易溶于醇。

别名和识别编码

Chemical Name	Cysteamine
Synonym	2-Aminoethanethiol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number	MFCD00008196
CAS Number	60-23-1
PubChem Substance ID	87562212
Beilstein Registry Number	635649
EC Number	200-463-0
Reaxys-RN	635649
Merck Number	2779
Chemical Name Translation	巯基乙胺
Wiswesser Line Notation	Z2SH
LabNetwork Molecule ID	LN00193207
InChI	InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2
Canonical SMILES	NCCS

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产品应用

具有解除金属对体内酶系统的损伤作用和具有抗氧化性质，可防止X线和放射性物质的损害。医药、农药、化妆品的中间体。

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P302+P352+P332+P313+P362+P364
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P332+P313
P201 Obtain special instructions before use. 使用前获取专门指示。
P405 Store locked up. 上锁保管。
P305+P351+P338+P337+P313
P301+P312+P330
P308+P313
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H302 Harmful if swallowed 吞食有害
H319 Causes serious eye irritation 严重刺激眼睛

RTECSKJ0175000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Signal word

Hazard Codes Xn

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

UN Number 3335 3259

Storage condition 0-10 0-10°C 2-8°C 2-8°C, stored under nitrogen 储存温度 2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Skin and Appendages - hair
REFERENCE :
   OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi.  Journal of the Osaka City
   Medical Center.  (Osaka, Japan)  V.4-23, 1955-74.  For publisher
   information, see OIGZDE.  Volume(issue)/page/year: 5,128,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 232 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 84 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
   Skin and Appendages - hair
REFERENCE :
   OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi.  Journal of the Osaka City
   Medical Center.  (Osaka, Japan)  V.4-23, 1955-74.  For publisher
   information, see OIGZDE.  Volume(issue)/page/year: 5,128,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulend

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 mg/L
REFERENCE :
   APMBAY Applied Microbiology.  (Washington, DC)  V.1-30, 1953-75.  For
   publisher information, see AEMIDF.  Volume(issue)/page/year: 12,234,1964

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 68,351,1979

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   5,199,1978

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   5,199,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 42 gm/kg
SEX/DURATION            : female 70 day(s) pre-mating  - 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,523,1967

其他信息

外观性质:白色结晶, 有不适气味。
图谱信息:巯基乙胺(60-23-1)质谱(MS) 巯基乙胺(60-23-1)核磁图( 1 HNMR) 巯基乙胺(60-23-1)红外图谱(IR1) 巯基乙胺(60-23-1)红外图谱(IR2)
储运特性:库房通风低温干燥
用途一:医药、农药、化妆品的中间体。
毒性分级:中毒
MOL 文件:60-23-1.mol
巯基乙胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 TA064802 2-氨基乙硫醇 25g 698元 2011/08/23 62006980 半胱胺;巯乙胺; 2-巯基乙胺; 硫代乙醇胺; 2-氨基乙硫醇 5g 660元 2011/04/16 A0648 2-氨基乙硫醇 2-Aminoethanethiol 500G 5130元
上游原料:氢硫酸 --> 氮丙啶
易溶于水及醇，呈碱性反应，在空气中易氧化成为二硫化物。游离碱极不稳定，一般制成盐酸盐[156-57-0]。
TCI Shanghai:2-氨基乙硫醇 2-Aminoethanethiol,>;95.0%(T)(60-23-1)
F:1-3-10-13-34
MSDS 信息:巯乙胺(60-23-1).msds
下游产品:噻唑磷 --> 辅酶 A --> (3-((6-氯-3-吡啶基)甲基)-1,3-噻唑啉-2-亚基)氰胺
Sigma Aldrich:60-23-1(sigmaaldrich)
灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
用途二:具有解除金属对体内酶系统的损伤作用和具有抗氧化性质，可防止X线和放射性物质的损害。医药、农药、化妆品的中间体。
方法一:由乙醇胺与溴化氢加成得β-溴化乙胺，再于硫酸存在下与二硫化碳环合，最后水解而得。此法反应容易控制，对设备要求不高，适于工业采用。另外，由环乙胺与硫化氢加成，亦可制得。
急性毒性:腹腔-大鼠LD50: 232 毫克/公斤; 口服-小鼠LD50: 625 毫克/公斤
可燃性危险特性:可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾
类别:有毒物品