CAS 51-79-6 MFCD00007966-Urethane 氨基甲酸乙酯 TAO{mole}

Urethane 氨基甲酸乙酯

CAS 51-79-6 MFCD00007966

化学结构图

SMILES: CCOC(N)=O

化学属性

Mol. Formula	C3H7NO2
Mol. Weight	89.09
Density	1.1
Vapor Density	3.07 (vs air)
Boiling Point	184°C at 760 mmHg
Vapor Pressure	10 mmHg ( 77.8 °C)
Melting Point	48-50°C
Flash Point	92.22°C
TSCA	Yes
Solubility	略溶于水
Stability	对湿度敏感
Appearance	无色结晶或白色粉末，易燃，无臭，具有清凉味，与硝石相似。熔点48-50℃，沸点182-184℃，103℃（7.2kPa）时升华，相对密度0.9862，闪点92℃。易溶于水、乙醇、乙醚和甘油，微溶于三氯甲烷和橄榄油。水溶液呈中性。
pH	:A

别名和识别编码

Chemical Name	Urethane
CAS Number	51-79-6
Synonym	Urethane {LY} Urethane {} {LY} Urethane {} {} {LY} Urethane {} {} {} {LY} Urethane {} {} {} {} {LY} Urethane {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Urethane {} {} {} {} {} {} {} {} {} {} {} {}
EC Number	200-123-1
Beilstein Registry Number	635810
MDL Number	MFCD00007966
PubChem Substance ID	87565237
Merck Number	9874
Reaxys-RN	635810
Chemical Name Translation	氨基甲酸乙酯
Wiswesser Line Notation	ZVO2
LabNetwork Molecule ID	LN00194423
InChI	InChI=1S/C3H7NO2/c1-2-6-3(4)5/h2H2,1H3,(H2,4,5)
Canonical SMILES	NC(OCC)=O

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分类

Mutagenesis Research Chemicals
{SNA} All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, Ester, Esters, Flavors and Fragrances, Food & Beverage Standards, S-Z, Standards for Personal Care and Cosmetic Products, Substance Classification, neats, prohibited substances (EU-REGULATION No 1223/2009)
{SNA} All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Chromatography, Ester, Flavors and Fragrances, Food & Beverage Standards, S-Z, Substance Classification
{SNA} Amides, Buildi
{uni_hamburg} no charge; carbamate; 1fragment

产品应用

生化研究，有机合成，溶剂。

安全信息

Signal word Danger

GHS Symbol

WGK Germany3

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R45 May cause cancer 可能致癌

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P301+P312+P330
P302+P352+P312+P362+P364
P304+P340+P312
P305+P351+P338
P308+P313
P313 Get medical advice/attention. 获取医疗咨询/就医
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害
H302+H312
H350 May cause cancer 可能致癌

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSFA8400000

Hazard Codes 9 T

Packing GroupIII

UN Number 3077

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/m3/10D-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
   211, 1000 AE Amsterdam, Netherlands)  V.76-    1985-
   Volume(issue)/page/year: 81,742,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
                          female 11 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 gm/kg/56W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Skin and Appendages - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 5,911,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1000 mg/kg/W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22,

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation,"
   Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed.
   Rep. Ger., 1931  Volume(issue)/page/year: -,-,1931

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1809 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   57,37,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 84,227

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - peritonitis
REFERENCE :
   NCISA* Progress Report for Contract No. PH-43-63-1132, Submitted to the
   National Cancer Institute by Scientific Associates, Inc.  (6200 S. Lindberg
   Blvd., St. Louis, MO 63123)  Volume(issue)/page/year: PH-43-62-483

TYPE OF TEST            : LDLo - Lowest published lethal d

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 56200 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   30,195,1970

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 55000 ppm/6H
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(iss

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 1000 ppm
REFERENCE :
   APMBAY Applied Microbiology.  (Washington, DC)  V.1-30, 1953-75.  For
   publisher information, see AEMIDF.  Volume(issue)/page/year: 6,45,1958

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 2 mg/disc
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/p

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   24,68,1994

TYPE OF TEST            : TDLo - Lowest publ

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 400 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   ARPAAQ Archives of Pathology.  (Chicago, IL)  V.5(3)-50(3), 1928-50;
   V.70-99, 1960-75.  For publisher information, see APLMAS.
   Volume(issue)/page/year: 81,174,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 gm/kg
SEX/DURATION            : male 20 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   HIKYAJ Hinyokika Kiyo.  Journal of Urology.   (Kyoto Daigaku Igakubu,
   Hinyokikagaku Kyoshitsu, 54 Kawara-machi, Shogain, Sakyo-ku, Kyoto 606,
   Japan)  V.1-    1955-  Volume(issue)/page/year: 12,1339,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 400 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   ARPAAQ Archives of Pathology.  (Chicago, IL)  V.5(3)-50(3), 1928-50;
   V.70-99, 1960-75.  For publisher information, see APLMAS.
   Volume(issue)/page/year: 81,174,1966

TYPE OF TEST            : TDLo - Lowest

TYPE OF TEST            : TDLo - Lo

其他信息

用途二:该品用作医药、农药、香料的中间体，用于生产安眠药、镇静剂。用作马钱子碱、间苯二酚的解毒剂、杀菌剂、注射剂的助溶剂和印染工业着色剂，也可用于生物化学研究。此外，尿烷本身可作成药使用，具有抗癌性能，用于治疗多发性骨髓瘤和慢性白血病等。
MOL 文件:51-79-6.mol
TCI Shanghai:氨基甲酸乙酯 Ethyl Carbamate,>;98.0%(GC)(N)(51-79-6)
氨基甲酸乙酯价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30191228 乌来糖 500g 52.7元 2011/04/16 C0028 氨基甲酸乙酯 Ethyl Carbamate 25G 219元 2011/04/16 C0028 氨基甲酸乙酯 Ethyl Carbamate 500G 1320元
Acros Organics:Urethane, 99%(51-79-6)
常规方法:采用纸板桶包装，内衬塑料袋，每桶25kg。要密封避光存放。贮于阴凉、通风、干燥处，运输中防火、防晒、防潮。按有毒化学品规定贮运。
下游产品:双甲眯 --> 2,4-二氯-5-氰基嘧啶 --> 乙吗噻嗪 --> 1-环己基尿嘧啶 --> 1-环己基-1,2,3,4-四氢-2,4-二氧嘧啶-5-腈 --> 奈法唑酮 --> 羟基脲 --> N,N-二氯氨基甲酸乙酯 --> 双氧威
Alfa Aesar:Ethyl carbamate, 98%(51-79-6)
无臭，味凉而咸。103℃(7.20kPa)时升华。易溶于水、醇、醚、甘没、氯仿和橄榄油，1g溶于0.5ml水、0.8ml乙醇、0.9ml氯仿、1.5ml乙醚、2.5ml甘油和32ml橄榄油，水溶液呈中性。有潜在致癌作用。
用途一:用于有机合成及生化研究
Sigma Aldrich:51-79-6(sigmaaldrich)
MSDS 信息:Carbamic acid ethyl ester(51-79-6).msds
方法一:硝酸与尿素反应生成硝酸尿素，然后加乙醇、亚硝酸钠，在硫酸存在下，进行酯化反应，生成尿烷和硝酸钠，反应产物经过滤除去硝酸钠，再经蒸馏、结晶、干燥，制得成品。原料消耗定额：硝酸（96%）1230kg/t、尿素116kg/t、乙醇330kg/t、亚硝酸钠1370kg/t。
蒸气密度:3.07 (vs air)
蒸气压:10 mm Hg ( 77.8 °C)
图谱信息:氨基甲酸乙酯(51-79-6)红外图谱(IR2) 氨基甲酸乙酯(51-79-6)质谱(MS) 氨基甲酸乙酯(51-79-6)核磁图( 1 HNMR) 氨基甲酸乙酯(51-79-6)核磁图( 13 CNMR) 氨基甲酸乙酯(51-79-6)红外图谱(IR3) 氨基甲酸乙酯(51-79-6)红外图谱(IR1) 氨基甲酸乙酯(51-79-6)Raman光谱
防护措施:本品有毒。对家兔静脉注射LD50为2000mg/kg体重。白鼠口服LD50为2700mg/kg体重。生产设备应注意密闭性良好，防止跑、冒、滴、漏，贮存容器应标以有毒标记，防止误食。操作人员应戴橡皮手套。皮肤沾染后，用清水和肥皂洗净；如发生误食应及时就医。