CAS 63-74-1 MFCD00007939-Sulfanilamide, 99.5%, reference material 磺胺 TAO{mole}

Sulfanilamide, 99.5%, reference material 磺胺

CAS 63-74-1 MFCD00007939

化学结构图

SMILES: Nc1ccc(S(N)(=O)=O)cc1

化学属性

Mol. Formula	C6H8N2O2S
Mol. Weight	172.20
Melting Point	164-167°C
Density	1.08
TSCA	Yes
Stability	对湿度敏感
Solubility	7.5 g/L at 25 °C
Boiling Point	400.5°C at 760 mmHg
Flash Point	196°C
Redox	Reduction

别名和识别编码

Chemical Name	Sulfanilamide, 99.5%, reference material
Synonym	Sulfanilamide {LY} Sulfanilamide {} {LY} Sulfanilamide {} {} {LY} Sulfanilamide {} {} {} {LY} Sulfanilamide {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Sulfanilamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number	MFCD00007939
CAS Number	63-74-1
Beilstein Registry Number	511852
EC Number	200-563-4
Merck Number	8925
PubChem Substance ID	87575729
Reaxys-RN	511852
Chemical Name Translation	磺胺
Wiswesser Line Notation	ZSWR DZ
LabNetwork Molecule ID	LN00194410
InChI	InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)
Canonical SMILES	O=S(C1=CC=C(N)C=C1)(N)=O

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

用于亚硝酸盐的测定，生化研究，有机合成。

安全信息

WGK Germany3

RTECSWO8400000

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Signal word Warning

Precautionary statements

P301+P317

Hazard statements

H303 May be harmfully swallowed 吞食可能有害

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

GHS Symbol

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 135 mg/kg/9W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 68,330,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 211,367,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,1072,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 31(3),11,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABANAE Antibiotics Annual.  (New York, NY)  1953-60.  For publisher
   information, see AMACCQ.  Volume(issue)/page/year: 5,972,1957/1958

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED

{haza

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 ug/disc
REFERENCE :
   APMBAY Applied Microbiology.  (Washington, DC)  V.1-30, 1953-75.  For
   publisher information, see AEMIDF.  Volume(issue)/page/year: 6,23,1958

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 375 mg/kg
REFERENCE :
   ENECEV Environment and Ecology. (Environment and Ecology, C/o Dr. S.K.
   Konar, Dept. of Zoology, Kalyani University, Kalyani 741253, West Bengal,
   India)  V.1-    1983-  Volume(issue)/page/year: 4,397,1986

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 30 umol/L
REFERENCE :
   SinJF# Personal Communication from J.F. Sina, Merck Institute for
   Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
   Volume(issue)/page/year: 26OCT1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 22 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   JHHBAI Bulletin of the Johns Hopkins Hospital.  (Baltimore, MD)  V.1-119,
   1889-1966.  For publisher information, see JHMJAX. Volume(issue)/page/year:
   66,139,1940

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 22 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   JHHBAI Bulletin of the Johns Hopkins Hospital.  (Baltimore, MD)  V.1-119,
   1889-1966.  For publisher information, see JHMJAX. Volume(issue)/page/year:
   66,139,1940

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 974 mg/kg
SEX/DURATION            : female 34-37 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   117,1314,1941

其他信息

用途一:用作测定亚硝酸盐的试剂，也用于制药工业
可燃性危险特性:遇明火、高温、强氧化剂可燃；燃烧排放氮氧化物和硫氧化物刺激烟雾
磺胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30172216 磺胺;磺酰胺;氨苯磺胺;磺酰胺 100g 20.2元 2011/08/23 30172226 磺胺;磺酰胺;氨苯磺胺;磺酰胺 100g 17元 2011/04/16 S0833 磺胺 [用于生化研究] Sulfanilamide [for Biochemical Research] 5G 377元
{Chem
毒性分级:中毒
用途二:用于医药工业，是合成磺胺类药物的主要原料
产品特性:磺胺又称对氨基苯磺酰胺、磺酰胺、对苯胺磺酰胺、对磺酰胺苯胺。从乙醇水溶液中析出者为白色叶片状结晶或结晶性粉末，无臭，味先微苦而后甜，遇光变色。相对分子质量172.22。相对密度1.08。熔点165～166℃。不溶于苯、乙醚、氯仿，溶于水(g/l)： 10℃时2.6、25℃时7.5、40℃时 17.0、60℃时40.0、100℃时477，也溶于乙醇，每 37ml乙醇可溶1g，每5ml丙酮可溶1g，溶于甘油、丙二醇，溶于盐酸及氢氧化钠(钾)溶液，磺胺水溶液石蕊试纸呈中性，0.5%的水溶液 pH=5.8～6.1。光照下颜色变深。人类大量服用磺胺，可引起恶心、呕吐、腹泻，对肝、肾造成影响，还能引起耳鸣、眩晕、头痛，甚至出现各种神经性症状，直至死亡。狗经口LD50 2000mg/kg。【药效学】作用机理是干扰病原微生物所需核酸的合成，使细菌缺乏营养而停止生长、发育和繁殖。对溶血性链球菌、葡萄球菌及脑膜炎球菌有抑杀作用。【药动学】口服易自胃肠道吸收，体内分布较广，能穿透血脑屏障进入脑组织，并能穿透胎盘屏障进入胎儿。排泄较快，主要以代谢物从肾脏排出。【临床应用】主要用于溶血性链球菌、葡萄球菌所致外伤感染，及局部创面感染等。【用途】本品为磺胺类药物中毒性较低者，对婴儿、妊妇、产妇及月经期间均可应用，但不得大量服用。对溶血性链球菌感染(丹毒、产褥热、扁桃腺炎)、尿道感染(淋病)等均有效;也是合成其他磺胺类药物的中间体(如磺胺脒、磺胺甲嘧啶及磺胺甲氧嗪等)。
外观性质:白色颗粒或粉末状结晶，无臭，味微苦。
用途四:对氨基苯磺酰胺是除草剂磺草灵的中间体，也是医药磺胺的中间体。
F:10
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下游产品
急性毒性:口服- 大鼠 LD50: 3900 毫克/ 公斤; 口服-小鼠 LD50: 3000 毫克/公斤
用途五:该品是磺胺类药物的重要中间体。
储运特性:包装完整、轻装轻放; 库房通风、远离明火、高温、与氧化剂分开存放
常规方法:采用
Alfa Aesar:磺胺,98% Sulfanilamide, 98%(63-74-1)
TCI Shanghai:磺胺[用于重氮化滴定] Sulfanilamide [for Diazotization Titration],>;99.9%(T)(63-74-1)
Acros Organics:磺胺 Sulfanilamide, 98%(63-74-1)
下游产品:2,6-二氯苯胺 --> 2,3,4-三氟硝基苯 --> 磺胺喹恶啉 --> 磺草灵 --> 磺胺脒 --> 荧光增白剂DCB --> 磺胺氯哒嗪钠 --> 磺胺二甲基嘧啶 --> 偶氮酪蛋白 --> 3,5-二溴对氨基苯磺酰胺 --> 2,6-二
方法一:其制备方法有以下几种。 (1)以乙酰苯胺为原料由乙酰苯胺与氯
类别:农药
防护措施:可作药物使用，对细菌的生长繁殖有抑制作用。大量服用磺胺，可因吸收与排泄失去平衡而致死。狗经口LD50为2000mg/kg。人体大量服用磺胺可引起食欲减退、呕吐、腹泻等副作用，对肝、肾造成影响，亦可引起耳鸣、眩晕、头痛，甚至可出现各种精神症状，直至死亡。操作人员应穿戴防护用具。