CAS 59-46-1 MFCD00007893-2-(Diethylamino)Ethyl 4-Aminobenzoate 普鲁卡因 TAO{mole}

2-(Diethylamino)Ethyl 4-Aminobenzoate 普鲁卡因

CAS 59-46-1 MFCD00007893

化学结构图

SMILES: CCN(CC)CCOC(=O)c1ccc(N)cc1

化学属性

Mol. Formula	C13H20N2O2
Mol. Weight	236.32
Flash Point	195-196°C/17mm
Melting Point	60.0 to 64.0 deg-C
Boiling Point	195-196°C 17mm
Solubility	soluble
Appearance	白色结晶。熔点61℃。二水物熔点51℃，其盐酸盐（[51-05-8]）为白色结晶或结晶性粉末，熔点153-156℃。易溶于水，略溶于乙醇，微溶于氯仿，几乎不溶于乙醚。无臭，味微苦，随后有麻痒感。其水溶液久贮、曝光或受热后易分解失效。

别名和识别编码

Chemical Name	2-(Diethylamino)Ethyl 4-Aminobenzoate
CAS Number	59-46-1
Alfabeta Name	PROCAINE
MDL Number	MFCD00007893
Synonym	beta-(Diethylami Gerovital anadolor beta-(dieth Allocaine LABOTEST-BB LT00772261 奴夫卡因 P-AMINOBENZOYLDIETHYLAMINOETHANOL HYDROCHLORIDE 盐酸普罗卡因 4-Aminobenzoic acid diethylaminoethyl ester NOVOCAINE HYDROCHLORIDE 2-DIETHYLAMINOETHYL 4-AMINOBENZOATE HYDROCHLORIDE anesthesol 4-AMINO-BENZOIC ACID 2-DIETHYLAMINO-ETHYL ESTER TIMTEC-BB SBB001081 2-(Diethylamino)ethyl 4-aminobenzoate 2-(diethylamino)ethylp-aminobenzoate PROCAINE 4-AMINOBENZOIC ACID 2-DIETHYLAMINOETHYL ESTER HYDROCHLORIDE 盐酸普鲁卡因 Duracaine p-Aminobenzoic acid 2-diethylaminoethyl ester 4-氨基苯甲酸-2-(二乙氨基)乙酯单盐酸盐 2-DIETHYLAMINO-4-AMINO-BENZOATE HYDROCHLORIDE 2-diethylaminoethylp-aminobenzoate 2-diethylaminoethylesterkyselinyp-aminobenzoove Procaine ART-CHEM-BB B006598 4-Aminobenzoic acid diethylaminoethyl es 4-amino-benzoicaci2-(diethylamino)ethylester 對胺苯甲酸Β-二乙胺乙酯鹽酸鹽 PROCAINE HYDROCHLORIDE beta-Diethylaminoethyl 4-aminobenzoate aminocaine AKOS B006598 P-AMINOBENZOIC ACID DIETHYLAMINO-ETHYL ESTER HYDROCHLORIDE 4-aminobenzoicac 2-二乙基氨基乙基4-氨基苯甲酸酯盐酸盐 2-diethylaminoethyl4-aminobenzoate PROCAIN HYDROCHLORIDE 普魯卡因鹽酸鹽 P-AMINOBENZOIC ACID 2-(DIETHYLAMINO)ETHYL ESTER 4-氨基苯甲酸 2-二乙基氨基乙基酯 2-DIETHYLAMINOETHYL P-AMINOBENZOATE HYDROCHLORIDE 2-(Diethylamino)ethyl p-aminobenzoate Benzoicacid,4-amino-2-(diethylamino)ethylester
EC Number	200-077-2
Chemical Name Translation	普鲁卡因
Merck Number	7757
Reaxys-RN	913480
PubChem Substance ID	4914
Wiswesser Line Notation	ZR DVO2N2&2
Beilstein Registry Number	0913480
LabNetwork Molecule ID	LN00173859
InChI	InChI=1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3

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安全信息

Warnings IRRITANT

Packing GroupIII

Hazard Codes T

Hazard Class6.1

UN Number UN 2811 6.1/PG 3 3249

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

WGK Germany3

RTECSDG2100000

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R25 Toxic if swallowed 吞咽有毒
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

GHS Symbol

Signal word

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P301+P312+P330
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。

Hazard statements

H302 Harmful if swallowed 吞食有害

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 21500 ug/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
REFERENCE :
   BDHU** "Nachprufung der Toxicitat von Novocain und Tutocain bei
   Chloralisierten Tieren, Dissertation," Barke, A., Pharmakologischen Institut
   der Tierarztlichen Hochschule zu Hannover, Fed. Rep. Ger., 1936
   Volume(issue)/page/year: -,-,1936

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KLWOAZ Klinische Wochenscrift.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1922-  Volume(issue)/page/year:
   31,97,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1600 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - stiffness
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   JNNPAU Journal of Neurology, Neurosurgery and Psychiatry.  (British Medical
   Journal, POB 560B, Kennebunkport, ME 04046)  V.7-    1944-
   Volume(issue)/page/year: 34,20,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 29,425,1966

{hazard_co

其他信息

局部麻醉药:盐酸普鲁卡因是一种局部麻醉药，能暂时阻断神经纤维的传导而具有麻醉作用，作用强，毒性低，且无成瘾性，但对皮肤、粘膜穿透力弱，不适于表面麻醉，临床上主要用于浸润、脊椎及传导麻醉。常温下白色细微针状结晶或结晶性粉末，无臭，味微苦而麻，易溶于水，溶于乙醇，微溶于氯仿，几乎不溶于乙醚。盐酸普鲁卡因结构中酯键可发生水解，生成对氨基苯甲酸和二乙氨基乙醇，在一定条件下，对氨基苯甲酸可进一步脱羧生成有毒的苯胺。盐酸普鲁卡因结构中具有芳伯氨基，容易氧化变色，pH值，温度，紫外线、氧和金属离子均可加速氧化变色。本品水溶液在pH3.0～5.0间较稳定。故配制盐酸普鲁卡因注射液时，一般需加酸调pH3.3～5.5之间，并严格控制灭菌温度和时间，以100℃流通蒸气灭菌30min为宜，并应注意遮光，密闭保存。本品结构中的芳伯氨基在稀盐酸中，与亚硝酸钠生成重氮盐，加碱性β-萘酚发生偶合反应，生成猩红色的偶氮化合物。
可燃性危险特性:可燃;燃烧产生有毒氮氧化物和氯化氢烟雾
MSDS 信息:Procaine hydrochloride(51-05-8).msds
TCI Shanghai:盐酸普鲁卡因 Procaine Hydrochloride,>;98.0%(LC)(T)(51-05-8)
Acros Organics:盐酸普鲁卡因 Procain
盐酸普鲁卡因价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 A1163 盐酸普鲁卡因 Procaine Hydrochloride 25G 150元 2010/06/21 207310050 盐酸普鲁卡因 Procaine hydrochloride 99% 5 GR 225元 2010/06/21 207315000 盐酸普鲁卡因 Procaine hydrochloride 99% 500 GR 1622元
类别:有毒物品
外观性质:白色结晶或结晶性粉末，无臭，味微苦，随后有麻痹感。本品在水中易溶，略溶于乙醇，微溶于氯仿，不溶于乙醚。熔点：155-156 °C
方法一:对硝基苯甲酸与二乙氨基乙醇在二甲苯中回流酯化得到硝基卡因，再用铁粉还原成普鲁卡因，然后用盐酸盐得到成品。
下游产品:普鲁卡因青霉
盐酸普鲁卡因价格(试剂级):更新日期产品编号产品名称包装价格 2011/04/16 A1163 盐酸普鲁卡因 Procaine Hydrochloride 25G 182元 2010/06/21 207310050 盐酸普鲁卡因 Procaine hydrochloride 99% 5 GR 225元 2010/06/21 207315000 盐酸普鲁卡因 Procaine hydrochloride 99% 500 GR 1622元
用途一:局部麻醉药。其毒性低微，作用迅速安全。适用于局部麻醉，应用于眼、耳、鼻、齿等科手术，用于浸润麻醉、传导师麻醉及封闭疗法等。该品也用于生产普鲁卡因青霉素。
Alfa Aesar:2-二乙基氨基乙基4-氨基苯甲酸酯盐酸盐,99% 2-Diethylaminoethyl 4-aminobenzoate hydrochloride, 99%(51-05-8)
储运特性:库房通风低温干燥
上游原料:对硝基苯甲酸 --> 二乙氨基乙醇
MOL 文件:51-05-8.mol
图谱信息:盐酸普鲁卡因(51-05-8)核磁图( 1 HNMR) 盐酸普鲁卡因(51-05-8)红外图谱(IR2) 盐酸普鲁卡因(51-05-8)红外图谱(IR1)
急性毒性:口服-大鼠LD50: 200 毫克/公斤; 口服-小鼠 LD50: 175 毫克/公斤
Sigma Aldrich:51-05-8(sigmaaldrich)
毒性分级:高毒
敏感性:Ai
Acros Organics:盐酸普鲁卡因 Procaine hydrochloride, 99%(51-05-8)