Ethyl 4-aminobenzoate 4-氨基苯甲酸乙酯
CAS 94-09-7 MFCD00007892
化学结构图
SMILES: CCOC(=O)C1CCC(N)CC1
化学属性
| Mol. Formula | C9H11NO2 |
|---|---|
| Mol. Weight | 165 |
| Flash Point | >110°(230°F) |
| TSCA | Yes |
| Boiling Point | 310°C(lit.) |
| Melting Point | 89.0 to 92.0 deg-C |
| Density | 1.17 |
| Solubility | 难溶于水，易溶于醇、醚、氯仿。 |
别名和识别编码
| Chemical Name | Ethyl 4-aminobenzoate |
|---|---|
| CAS Number | 94-09-7 |
| Alfabeta Name | ETHYLAMINOBENZOATE 4- |
| Synonym | p-Aminobenzoic acid ethyl ester BENZOCAINUM {Chemicalbook} 4-AMINOBENZOIC ACID ETHYL ESTER Anaesthesin Anesthone {uni_hamburg} 4-Carbethoxyaniline ETHYL P-AMINOBENZOATE Ethyl 4-aminobenzoate 4-Aminobenzoic Parathesine 苯唑卡因 Parathesin Benzocaine BP98; Anesthesin; Parathes BENZOCAINE ######## Solu H Ethyl p-aminobenzenecarboxylate Hurricaine ETHYL 4-AMINOBENZOATE p-Ethoxycarboxylic aniline AETHOFORM {uni_hambur Ethyl p-aminobenzoate auralgan Benzocaine Orthesin Americaine Norcain ethyl 4-amino benzoate Amben et {u |
| MDL Number | MFCD00007892 |
| PubChem Substance ID | 2337 |
| Beilstein Registry Number | 14(3)1025 |
| EC Number | 202-303-5 |
| Reaxys-RN | 638434 |
| Merck Number | 1086 |
| Chemical Name Translation | 4-氨基苯甲酸乙酯 |
| Wiswesser Line Notation | ZR DVO2 |
| LabNetwork Molecule ID | LN00173915 |
| InChI | InChI=1S/C9H11NO2/c1-2-12-9(11)7-3-5-8(10)6-4-7/h3-6H,2,10H2,1H3 |
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分类
- {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia Metrological Institutes Standards, 分析/色谱
- {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; ester; 1fragment
- {SNA} Analytical/Chromatography,
- {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
- B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Core Bioreagents
- {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia & Metrological Institutes Standards, 分析/色谱
- {SNA} Core Bioreagents, Enzyme Inhibitors, Ion Channels, Monovalent Ion Channels,
- {SNA} Building Blocks,
产品应用
- 该品为局部麻醉药，用于创面，溃疡面及痔疮的止痛，也是镇咳药退嗽的中间体。
相关文献及参考
- Merck 14 ,1086
- Ayehunie, S., et al., Development Of An In Vitro Alternative Assay Method For Vaginal Irritation. Toxicology 279 , 130-8, (2011) 摘要
- Kholod, Y., et al.: Environ. Sci. Technol., 43, 9208 (2009),
- Qiao, C., et al., Liver-specific MicroRNA-122 Target Sequences Incorporated In AAV Vectors Efficiently Inhibits Transgene Expression In The Liver. Gene Ther. 18 , 403-10, (2011) 摘要
- Gavrilov, V., et al., Influenza Virus-like Particles As A New Tool For Vaccine Immunogenicity Testing: Validation Of A Neuraminidase Neutralizing Antibody Assay. J. Virol. Meth. 173 , 364-73, (2011) 摘要
- Merck: 14,1086 Beilstein:14(3)1025
- Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009),
- Perez-Garrido, Alfonso; Helguera, A., et al.: J. Pharm. Sci., 98, 4557 (2009),
- Merck: 14,1086
- Jászai, J., et al., Distinct And Conserved Prominin-1/CD133-Positive Retinal Cell Populations Identified Across Species. PLoS ONE 6 , e17590, (2011) 摘要
- Short: III/31a
- Quan, F.S., et al., Kinetics Of Immune Responses To Influenza Virus-like Particles And Dose-dependence Of Protection With A Single Vaccination. J. Virol. 83 , 4489-97, (2009) 摘要
- Ding, H., et al., Superior Neutralizing Antibody Response And Protection In Mice Vaccinated With Heterologous DNA Prime And Virus Like Particle Boost Against HPAI H5N1 Virus. PLoS ONE 6 , e16563, (2011) 摘要
安全信息
- H303 May be harmfully swallowed 吞食可能有害
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P307+P311
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P337+P313
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P302+P352+P333+P313+P362+P364
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P273 Avoid release to the environment. 避免释放到环境中。
- P305+P351+P338+P337+P313
- S24 Avoid contact with skin 避免皮肤接触；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S37 Wear suitable gloves 戴适当手套；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S22 Do not breathe dust 不要吸入粉尘；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R36 Irritating to eyes 刺激眼睛
GHS Symbol
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Rectal SPECIES OBSERVED : Human - infant DOSE/DURATION : 12 mg/kg TOXIC EFFECTS : Blood - methemoglobinemia-carboxyhemoglobin REFERENCE : NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 263,454,1960
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,315,1972
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis REFERENCE : TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (2),34,1996
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 216 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 17,900,1974
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其他信息
- 苯唑卡因价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0271 4-氨基苯甲酸乙酯 Ethyl 4-Aminobenzoate 500G 621元 2014/06/02 A0271 4-氨基苯甲酸乙酯 Ethyl 4-Aminobenzoate 25G 121元 2010/06/21 150781000 苯唑卡因 Ethyl 4-aminobenzoate 98% 100 GR 334元
- 脂溶性表面麻醉剂:苯唑卡因是一种脂溶性表面麻醉剂，与其它几种局麻药如利多卡因、地卡因等相比，其作用强度较小，因而在作用于粘膜时不会因麻醉作用而使人感到不适。它是一种脂溶性较强的药物，故而易与粘膜或皮肤的脂层结合，但不易透过而进人体内产生毒性。 苯唑卡因可作为奥索仿、奥索卡因、普鲁卡因等前体原料；同时，它在医药上又用作局部麻醉剂，有止痛、止痒作用，主要用于创面、溃疡面、粘膜表面和痔疮麻醉止痛和痒症，其软膏还可用作鼻咽导管、内突窥镜等润滑止痛。暂时缓解疼痛和瘙痒皮肤的不适，轻度烧伤、晒伤、创伤和昆虫叮咬。耳用制剂被用来减轻急性充血性、浓性外耳炎、游泳耳炎的疼痛和瘙痒以及耳外用。对牙痛、咽喉痛、口腔溃疡、各种痔疮、肛裂、外阴瘙痒也是有效的，作为男性生殖器脱敏剂使射精缓慢。或用作导管和内镜管的麻醉润滑剂。
- TCI Shanghai:4-氨基苯甲酸乙酯 Ethyl 4-Aminobenzoate,>;99.0%(GC)(T)(94-09-7)
- 外观性质:无色、无臭、无味的晶体。
- 图谱信息:苯唑卡因(94-09-7)核磁图( 13 CNMR) 苯唑卡因(94-09-7)质谱(MS) 苯唑卡因(94-09-7)红外图谱(IR3) 苯唑卡因(94-09-7)核磁图( 1 HNMR) 苯唑卡因(94-09-7)红外图谱(IR1) 苯唑卡因(94-09-7)Raman光谱 苯唑卡因(94-09-7)红外图谱(IR2)
- 上游原料:对氨基苯甲酸 --> 4-氨基邻苯二甲酸 --> 对硝基苯甲酸乙酯
- 毒害物质数据:94-09-7(Hazardous Substances Data)
- 1g该品溶于约2500ml水、5ml乙醇、2ml氯仿、4ml乙醚或30-50ml杏仁油及橄榄油，也溶于稀酸。在空气中稳定，无臭，味苦。
- EPA Substance Registry System:94-09-7(EPA Substance)
- Alfa Aesar:4-氨基苯甲酸乙酯,98% Ethyl 4-aminobenzoate, 98%(94-09-7)
- 用途一:用于化妆品紫外线吸收，局部麻醉药，用于创面、溃疡面及痔疮的止痛
- 海关编码:29224995
- 方法一:由对硝基苯甲酸乙酯[99-77-4]铁粉还原而得。
- MOL 文件:94-09-7.mol
- 用途二:该品为局部麻醉药，用于创面，溃疡面及痔疮的止痛，也是镇咳药退嗽的中间体。
- 下游产品:对氟苯甲酸 --> 苯佐那酯 --> 4-(正丁基氨基)苯甲酸乙酯
- 苯唑卡因价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 A0271 4-氨基苯甲酸乙酯 Ethyl 4-Aminobenzoate 500G 862元 2011/04/16 A0271 4-氨基苯甲酸乙酯 Ethyl 4-Aminobenzoate 25G 167元 2010/06/21 150781000 苯唑卡因 Ethyl 4-aminobenzoate 98% 100 GR 334元
