CAS 123-30-8 MFCD00007869-4-Aminophenol 4-氨基苯酚 TAO{mole}

4-Aminophenol 4-氨基苯酚

CAS 123-30-8 MFCD00007869

化学结构图

SMILES: NC1CCC(O)CC1

化学属性

Mol. Formula	C6H7NO
Mol. Weight	109
Melting Point	185-189
Density	1.21
Flash Point	195°(383°F)
TSCA	Yes
Boiling Point	284
Solubility	1.5 G/100 ML (20 ºC)
Stability	对光敏感

别名和识别编码

Chemical Name	4-Aminophenol
Synonym	4-Amino-1-hydroxybenzene 4-Amino-1-hydroxybenzene; 4-Hydroxyaniline 4-Aminophenol 4-Hydroxyanliline 4-氨基-1-羟基苯 4-氨基酚 4-羟基苯胺 ACETAMINOPHEN IMPURITY K AZOL Benzofur P C.I. 76550 C.I. Oxidation Base 6A CITOL Certinal Citol Durafur Brown RB Fouramine P Fourrine 84 Nako Brown R PARA AMINO PHENOL Paranol Pelagol P Base Rodinal Ursol P Ursol P base p-Aminofenol 对氨基酚 4-AMINOPHENOL 对羟基苯胺對氨基苯酚羅定那
CAS Number	123-30-8
PubChem Substance ID	403
EC Number	204-616-2
Beilstein Registry Number	13(3)991
MDL Number	MFCD00007869
Reaxys-RN	385836
Merck Number	462
Chemical Name Translation	4-氨基苯酚
InChIKey	PLIKAWJENQZMHA-UHFFFAOYSA-N
Wiswesser Line Notation	ZR DQ
LabNetwork Molecule ID	LN00192892
InChI	InChI=1S/C6H7NO/c7-5-1-3-6(8)4-2-5/h1-4,8H,7H2

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

检定金，测定铜、铁、镁、钒、亚硝酸盐和氰酸盐，抗氧剂。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H332 Harmful if inhaled 吸入有害
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H302 Harmful if swallowed 吞食有害
H302+H332

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes 6.1 Xn;N

RTECSSJ5075000

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
P301+P312
P301+P312+P330
P302+P350
P302+P352+P333+P313+P362+P364
P304+P340
P305+P351+P338
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Warning

Safety Statements

S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R50/53
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

UN Number 2512

Storage condition Refrigerator 密封避光保存。储存温度2-8℃ Air & Light Sensitive 0-10°C 0-10

Packing GroupIII

Hazard Class6.1

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Fr

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 375 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Lungs, Thorax, or Respiration - cyanosis
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets.  (1810
   Frontage Rd., Northbrook, IL 60062)  Volume(issue)/page/year: 29-4/1973

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 37 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
   Blood - methemoglobinemia-carboxyhemoglobin
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie.  (Leipzig,
   Ger. Dem. Rep.)  V.1-109, 1873-1925.  For publisher information, see NSAPCC.
    Volume(issue)/page/year: 72,241,1913

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 56200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 173,233,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2 umol/plate
REFERENCE :
   45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of
   the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds.,

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 80,761,1991

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   26,163,1995

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 umol/kg
REFERENCE :
   IJMRAQ Indian Journal of Medical Research.  (Indian Council of Medical
   Research, Ansari Nagar, New Delhi 110 029, India)  V.1-    1913-
   Vo

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 15 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam,

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 150 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   63,264,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 150 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   63,264,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 200 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - body wall
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   63,264,1982

TYPE

Restrict 危险品

其他信息

用途四:检定金，测定铜、铁、镁、钒、亚硝酸盐和氰酸盐，抗氧剂。
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上游原料:盐酸 --> 硫酸 --> 发烟硫酸 --> 铁粉 --> 焦亚硫酸钠 --> 4-硝基苯酚 --> 4-硝基苯酚钠 --> 4-硝基儿茶酚 --> 硝基苯酚 --> 苯基羟胺 --> 精细化学品
制备方法:对硝基氯苯在氢氧化钠中水解成对硝基苯酚钠，酸化后用铁粉还原而得4-氨基苯酚。在配碱釜中将氢氧化钠配制成浓度为137～140g/L的溶液，然后将其加入到水解釜内，加入熔融的对硝基氯苯，加热升温到152℃，釜内压力为0.4～0.42MPa(表压)，停止加热，水解反应放出的热量使温度与压力上升到165℃、0.6MPa (表压)，反应3小时，取样分析，使油状馏出物 <0.5%后，水解到终点。冷却至120℃。将水和98%的浓硫酸加入到第一结晶釜中，然后压入水解物，冷却到50～55℃，加入浓硫酸，使刚果红试纸呈紫色，继续冷却至30℃，抽滤到离心机中进行脱水。在还原釜内加入上批对氨基苯酚精制过滤后的母液，加热到90℃，加入铁粉和30%的盐酸，在沸腾状态下交替加入铁粉和对硝基苯酚，加料过程视反应情况(如溢锅时)，应补入冷的精制过滤母液。沸腾还原到终点(反应液滴于白色滤纸上，渗圈应无色)。补入一定量的热精制母液，加入氧化镁至反应液中无铁离子。静置30分钟，放出上层清液，下层铁泥用98℃结晶过滤母液打浆，过滤，滤液打入第二结晶釜内。在第二结晶釜内于4小时内降温到60～65℃，放入第三结晶釜在4小时内继续降温到25℃，维持30分钟，离心过滤。在精制釜内配成SO2含量为4%～5%的重亚硫酸氢钠溶液，加入结晶过滤的滤饼，搅拌1.5小时，离心过滤，滤饼进行负压气流干燥，得对氨基苯酚成品，精制母液于下批还原时循环使用。
下游产品:N-乙酰对氨基酚 --> 对乙氧基苯胺 --> 乙二醇单丁醚 --> 6-羟基喹啉 --> 硫化蓝CV --> 硫化深蓝3R --> 靛酚乙酸酯 --> 洛克沙砷 --> N-(1,3-二甲基丁基)-N'-苯基对苯二胺 --> 硫化红棕B3R --> 硫化红6 --> 弱酸性嫩黄
Acros Organics:对氨基苯酚 4-Aminophenol, 97.50%(123-30-8)
方法一:有铁粉还原法、苯酚亚硝化法、偶合还原法等。1.铁粉还原法由对硝基酚还原而得。原料消耗定额：硝基苯酚（工业品）1388kg/t、铁粉1778kg/t、30%盐酸200kg/t。2.苯酚亚硝化法由苯酚经亚硝化、还原、酸析而得。3.偶合还原法以苯胺为原料，经重氮化、偶合、铁粉还原而得。4.硝基苯催化氢化法多以铂，钯或二者作催化剂，在10-20%硫酸水溶液中氢化还原为苯基羟胺，随即转位对氨基酚，收率70-80%。在反应系统中加入表面活性剂等对提高产率有一定效果。5.硝基苯电解还原法日本三井东压精细化学品公司采用在硫酸溶液中电解还原硝基苯，经苯基羟胺转位成对氨基酚，1977年6月该公司在大牟田工厂内建成一套1000吨/年装置。
毒性和防护:有毒，对氨基苯酚具有苯胺和苯酚的双重毒性。可经皮肤吸收引起皮炎，能引起高铁
Sigma Aldrich:123-30-8(sigmaaldrich)
图谱信息:4-氨基苯酚(123-30-8)红外图谱(IR1) 4-氨基苯酚(123-30-8)核磁图( 13 CNMR) 4-氨基苯酚(123-30-8)质谱(MS) 4-氨基苯酚(123-30-8)核磁图( 1 HNMR)
外观性质:白色至灰褐色结晶。
可燃性危险特性:明
4-氨基苯酚价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80005425 4-氨基酚;对氨基酚;4-羟基苯胺;4-氨基-1-羟基苯 50g 22元 2011/08/23 80005426 4-氨基酚;对氨基酚;4-羟基苯胺;4-氨基-1-羟基苯 100g 44.5元 2011/08/23 80005427 4-氨基酚;对氨基酚;4-羟基苯胺;4-氨基-1-羟基苯 250g 100元
常规方法:采用铁桶、纸桶或纤维板桶内衬塑料袋包装，每桶净重35kg、40kg或50kg。贮存时要避光，防止受热、受潮。按有毒危险品规定贮运。