CAS 95-69-2 MFCD00007842-4-Chloro-2-Methylaniline 4-氯-2-甲基苯胺 TAO{mole}

4-Chloro-2-Methylaniline 4-氯-2-甲基苯胺

CAS 95-69-2 MFCD00007842

化学结构图

SMILES: Cc1cc(Cl)ccc1N

化学属性

Mol. Formula	C7H8ClN
Mol. Weight	141.60
Boiling Point	241°C at 760 mmHg
Melting Point	24-27°C
Refractive index	n20/D 1.583(lit.)
Density	1.19
Flash Point	99.44°C

别名和识别编码

Chemical Name	4-Chloro-2-Methylaniline
CAS Number	95-69-2
Alfabeta Name	CHLOROMETHYLANILINE 42---
MDL Number	MFCD00007842
Synonym	4-Chloro-2-methylaniline {LY} 4-Chloro-2-methylaniline {} {LY} 4-Chloro-2-methylaniline {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-methylaniline {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	87562256
EC Number	202-441-6
Beilstein Registry Number	12(4)1796
Reaxys-RN	878505
Chemical Name Translation	4-氯-2-甲基苯胺
Wiswesser Line Notation	ZR DG B1
LabNetwork Molecule ID	LN00008624
InChI	InChI=1S/C7H8ClN/c1-5-4-6(8)2-3-7(5)9/h2-4H,9H2,1H3
Canonical SMILES	C1=C(Cl)C=CC(=C1C)N

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分类

{SNA} 2002/61/EC, Alphabetical Index of Analytical Standards, Chemical Class, Method and Regulation Specific, All alphabetical sorted, Alpha Sort, Analytical Standards, Analytical/Chromatography, Aryl Amines MAK III, Category 1, C, CH, Chloro, Chromatography, Colors, Environmental Standards, European Community: ISO, DIN and DL 152, Halogenated, Life Sciences Standards,
Amines, Building Blocks, C7, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks
{SNA} 2002/61/EC, Additional Standards,

产品应用

农药、医药和染料的重要中间体。

安全信息

Warnings TOXIC

GHS Symbol

WGK Germany3

Hazard statements

H302+H312
H331 Toxic if inhaled 吸入中毒
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒
H350 May cause cancer 可能致癌
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes T,N

RTECSXU5000000

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P308+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....
P301+P312+P330
P302+P350
P273 Avoid release to the environment. 避免释放到环境中。
P301+P310
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P201 Obtain special instructions before use. 使用前获取专门指示。
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P308+P311
P405 Store locked up. 上锁保管。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P302+P352+P312+P362+P364

Signal word

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R45 May cause cancer 可能致癌
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R50/53
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

UN Number UN 2239 6.1/PG 3 2239

Packing GroupIII

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {}

Hazard Class6.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1058 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NNGADV Nippon Noyaku Gakkaishi.  Journal of the Pesticide Science Society of
   Japan.  (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170,
   Japan)  V.1-    1976-  Volume(issue)/page/year: 1,301,1976

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 310 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Gastrointestinal - nausea or vomiting
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   AHBAAM Archiv fuer Hygiene und Bakteriologie.  (Munich, Fed. Rep. Ger.)
   V.101-154, 1929-71.  For publisher information, see ZHPMAT.
   Volume(issue)/page/year: 110,12,1933

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 75 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AECTCV Archives of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   070944)  V.1-    1973-  Volume(issue)/page/year: 12,355,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 nmol/plate
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 34,157

TYPE OF TEST            : DNA repair
TEST SYSTEM             : B

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 11,184,1974

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 nmol/plate
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End S

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 400 ug/plate
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York, NY 10016)  V.B11-    1976-  Volume(issue)/page/year: 19,95,1984

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 gm/disc
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York, NY 10016)  V.B11-    1976-  Volume(issue)/page/year: 19,95,1984

其他信息

4-氯-2-甲基苯胺价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 A0704 4-氯-2-甲基苯胺 4-Chloro-2-methylaniline 25G 504元 2014/06/02 A0704 4-氯-2-甲基苯胺 4-Chloro-2-methylaniline 500G 3830元 2010/06/21 109371000 4-氯-2-甲基苯胺 4-Chloro-2-methylaniline 98% 100 GR 1759元
用途二:农药、医药和染料的重要中间体。
TCI Shanghai:4-氯-2-甲基苯胺 2-Amino-5-chlorotoluene,>;95.0%(GC)(95-69-2)
Sigma Aldrich:95-69-2(sigmaaldrich)
下游产品:4-氯-2-甲基苯甲酸 --> 灭虫隆 --> 4-氯-2-甲基苯基异硫氰酸酯
外观性质:片状结晶至棕色液体。
上游原料:甘氨酸 --> 苯甲酰氯 --> 邻甲基苯胺
方法一:由邻甲苯胺经氯化而得。可有多种氯化方法。邻甲苯胺盐酸盐以氯苯为溶剂，在50-60℃通氯反应可得4-氯邻甲苯胺。也可先经酰化，再经氯化、水解而得。将邻甲苯胺和氯苯混合搅拌，滴加乙酐，在70-80℃搅拌反应1.5h，冷却，于50℃左右通氯，此时突然生成大量白色固体。停止通氯，加入浓盐酸和水，于95℃搅拌回流反应2h。冷至室温，加碱液中和而得。收率70%以上。另一种方法是在酸性介质中，将邻甲苯胺盐酸盐与氯化氢和氧气的混合气体（或氯气和氧气）反应。
图谱信息:4-氯-2-甲基苯胺(95-69-2)红外图谱(IR3) 4-氯-2-甲基苯胺(95-69-2)红外图谱(IR2) 4-氯-2-甲基苯胺(95-69-2)核磁图( 13 CNMR) 4-氯-2-甲基苯胺(95-69-2)红外图谱(IR1) 4-氯-2-甲基苯胺(95-69-2)质谱(MS)
MOL 文件:95-69-2.mol
Acros Organics:4-氯-2-甲基苯胺 4-Chloro-2-methylaniline, 98%(95-69-2)
F:8-10
MSDS 信息:4-氯邻甲苯胺(95-69-2).msds
用途一:用作农药、医药中间体