CAS 70-34-8 MFCD00007056-Dinitrofluorobenzene 2,4-二硝基氟苯 TAO{mole}

Dinitrofluorobenzene 2,4-二硝基氟苯

CAS 70-34-8 MFCD00007056

化学结构图

SMILES: O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1

化学属性

Mol. Formula	C6H3FN2O4
Mol. Weight	186
Refractive index	n20/D 1.569(lit.)
Boiling Point	178
Density	1.482
Melting Point	25-27
Flash Point	>110°(230°F)
TSCA	Yes
Solubility	400 MG/L (25 ºC)

别名和识别编码

Chemical Name	2,4-Dinitrofluorobenzene
Synonym	1 Fluoro 2,4 dinitrobenzene 1,3-Dinitro-4-fluorbenzol 1-Fluor-2,4-dinitrobenzol 1-Fluoro-2,4-dinitro-benzene 1-Fluoro-2,4-dinitrobenzene 1-Fluoro-2,4-dinitrobenzene; 2,4-Dinitro-1-fluorobenzene; DNFB 1-Fluoro-2,4-dinitrobenzene 1-氟-2，4-二硝基苯 2,4-DINITRO-1-FLUOROBENZENE 2,4-DINITROFLUOROBENZENE 2,4-Dinitro-1-fluorobenzene 2,4-Dinitrobenzene fluoride 2,4-Dinitrofluorobenzene 2,4-dinitro-1-fluoro-benzen 4-Fluoro-1,3-dinitrobenzene Benzene, 1-fluoro-2,4-dinitro- Benzene, 2,4-dinitro-1-fluoro- DFB DNF DNF OR DNFB DNFB Dinitrofluorobenzene FDNB Fluoro-2,4-Dinitrobenzene Fluorodinitrobenzene Sanger's Reagens {} {} {} {} { {} {} {} {
CAS Number	70-34-8
PubChem Substance ID	6264
EC Number	200-734-3
Beilstein Registry Number	398632
MDL Number	MFCD00007056
Merck Number	4172
Chemical Name Translation	2,4-二硝基氟苯
Wiswesser Line Notation	WNR BF ENW
Reaxys-RN	398632
LabNetwork Molecule ID	LN00188567
InChI	InChI=1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H

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分类

{SNA} α-aminocarboxylic Acids, Amino Acid Analysis, Amino Acid Analysis Reagents, Amino Acids, Analytical Reagents, Analytical/Chromatography, Biochemicals and Reagents, Derivatization Reagents, Derivatization Reagents HPLC, Fluorescence, HPLC Derivatization Reagents, by Application, Halogenated, Peptide Analysis and Characterization, Peptides, UV-VIS
Activity, Biochemicals and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Fluorogenic
{uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; 1fragment
{SNA} Activity, Enzyme Substrates, Fluorogenic, 生化试剂, 酶、抑制剂和底物

安全信息

GHS Symbol

WGK Germany3

Hazard Codes 6.1 C,T T;C Xn

Hazard statements

H300 Fatal if swallowed 吞食致命
H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H311 Toxic in contact with skin 皮肤接触中毒
H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H318 Causes serious eye damage 严重伤害眼睛
H319 Causes serious eye irritation 严重刺激眼睛
H330 Fatal if inhaled 吸入致命
H335 May cause respiratory irritation 可能导致呼吸道刺激
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P301+P310+P330
P301+P312
P301+P316
P301+P317
P302+P352
P302+P352+P333+P313+P362+P364
P304+P340
P305+P351+P338
P305+P351+P338+P337+P313
P305+P354+P338
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P316
P317
P319
P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P333+P313
P333+P317
P337+P313
P337+P317
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P361+P364
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger Warning

RTECSCZ7800000

UN Number 2811 UN 3261 8/PG 2

Risk Statements

R22 Harmful if swallowed 吞咽有害
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R33 Danger of cumulative effects 有累积作用的危险
R34 Causes burns 会导致灼伤
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R38 Irritating to skin 刺激皮肤
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
R42/43
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24 Avoid contact with skin 避免皮肤接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Packing GroupII

Hazard Class6.1

Storage condition 2-8°C

Restrict {} 剧毒化学品危险品

Warnings 危化品目录(2015)

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   41,558,1947

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,17,1953

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   29,179,1969

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 80 ug/L
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   37,873,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/well/16H
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   15,219,1976

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 umol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 3,139,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 ug/plate
REFERENCE :
   SAIGBL Sangyo Igaku.  Japanese Journal of Industrial Health.  (Nippon Sangyo
   Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160,
   Japan)  V.1-    1959-  Volume(issue)/page/year: 29,34,1987

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 320 umol/L
REFERENCE :
   MGGEAE Molecular and General Genetics.

其他信息

可燃性危险特性:明火可燃;受热分解放出氮氧化物和氟化物
下游产品:2,4-二氯氟苯
类别:农药
毒性分级:高毒
Sigma Aldrich:70-34-8(sigmaaldrich)
MOL 文件:70-34-8.mol
Alfa Aesar:2,4-二硝基-1-氟苯,99% 1-Fluoro-2,4-dinitrobenzene, 99%(70-34-8)
方法一:以2,4-二硝基氯苯与无水氟化钾为原料，经亲核取代反应而得。
上游原料:2,4-二硝基氯苯
Hazard Note:Toxic
用途二:本品可制成2,4-二氯氟苯，后者是合成环丙沙星、培氟沙星、二氟沙星等喹喏酮类抗菌药的起始原料。本品也是一种重要的分析试剂，用来鉴定有机化合物中的氨基，尤其是用于检定肽及蛋白质末端氨基酸的氨基。检定时，2，4-二硝基氟苯与肽链的游离氨基作用，生成2，4-二硝基衍生物。将其水解后，末端氨基酸的N-（2，4-二硝基苯基）衍生物常为亮黄色结晶，易与其他氨基酸分离。用该方法结合其他方法，可确定蛋白质或多肽氨基端碳链的结构，称桑格法。本品也用于测定酚和咖啡，以及醛糖分析。
2,4-二硝基氟苯价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80056216 2，4-二硝基氟苯（剧毒）（阴凉） 100g 350元 2010/06/21 117030050 2,4-二硝基氟苯 2,4-Dinitrofluorobenzene 98% 5 GR 236元 2010/06/21 117030250 2,4-二硝基氟苯 2,4-Dinitrofluorobenzene 98% 25 GR 697元
急性毒性:口服-大鼠 LDL0: 50 毫克/公斤; 皮下-小鼠 LDL0： 100 毫克/公斤
海关编码:29049085
储运特性:库房通风低温干燥; 与还原剂、食品添加剂分开存放
Acros Organics:2，4-二硝基氟苯 2,4-Dinitrofluorobenzene, 98%(70-34-8)
MSDS 信息:2,4-二硝基-1-氟苯(70-34-8).msds
外观性质:黄色针状结晶, 液化后为澄黄色液体。
灭火剂:泡沫、二氧化碳、干粉、砂土。
用途一:用作医药、农药、染料中间体