CAS 70-25-7 MFCD00007034-1-Methyl-3-nitro-1-nitrosoguanidine 1-甲基-3-硝基-1-亚硝基胍 TAO{mole}

1-Methyl-3-nitro-1-nitrosoguanidine 1-甲基-3-硝基-1-亚硝基胍

CAS 70-25-7 MFCD00007034

化学结构图

SMILES: CN(N=O)C(=N)N[N+](=O)[O-]

化学属性

Mol. Formula	C2H5N5O3
Mol. Weight	147
Melting Point	118°C
Solubility	起反应 VIOLENTLY
Density	1.764
Stability	对热和光敏感

别名和识别编码

Chemical Name	1-Methyl-3-nitro-1-nitrosoguanidine
CAS Number	70-25-7
Synonym	N-METHYL-N'-NITRO-N-NITROSOGUANIDINE N-甲基-N'-硝基-N-亚硝基胍;MNNG 1-METHYL-3-NITRO-1-NITROSOGUANIDINE N-Methyl-N?-nitro-N-nitroso-guanidine N-Nitroso-N-methylnitroguanidine 1-Methyl-1-nitroso-3-nitroguanidine DIAZOMETHANE PRECURSOR RCRA waste number U163 N-甲基-N'-硝基-N-亚硝基胍 N'-Nitro-N-nitroso-N-methylguanidine MNG n-methyl-n’-nitro-n-nitroso-guanidin N-Methyl-N-nitroso-N'-nitroguanidine n-metylo-n’-nitro-n-nitrozoguanidyny 1-methyl-3-nitro-1-nitroso-guanidin N-Metylo-N'-nitro-N-nitrozoguanidyny N-Methyl-N'-nitro-N-nitrosoguanidine; Diazomethane precursor; MNNG 1-甲基3-硝基1-亚硝基胍(0309禁空运) 1-Methyl-1-nitroso-2-nitroguanidine N-Nitrosoguanidine 1-甲基-3-硝基-1-亚硝基胍(MNNG) 1-甲基3-硝基1-亚硝基胍(无法供) n’-nitro-n-nitroso-n-methylguanidine 1-nitroso-3-nitro-1-methylguanidine Guanidine, 1-methyl-3-nitro-1-nitroso- MNNG nci-c01423 N-Methyl-N',2-dioxohydrazinecarboximidohydrazide 2-oxide N-Methyl-N'-nitro-N-nitrosoguanidine N-METHYL-N-NITROSO-N'-NITROGUANIDINE Methylnitronitrosoguanidine 1-Methyl-1-Nitroso-3-nitroguanidine Guanidine, N-methyl-N'-nitro-N-nitroso- 1-Methyl-3-nitro-1-nitrosoguanidine N-Nitroso-N?-nitro-N-methylguanidine NA 1325 n-methylo-n’-nitro-n-nitrozoguanidyny(polish) NSC 9369 1-甲基-3-硝基-1-亚硝基胍 mnng(n-methyl-n’-nitro-n-nitrosoguanidine N-Methyl-N-nitrosonitroguanidin N-甲基-N′-硝基-N-亚硝基胍 MNNG 重氮甲烷前体
MDL Number	MFCD00007034
PubChem Substance ID	87572565
Beilstein Registry Number	1779490
EC Number	200-730-1
Reaxys-RN	1779490
Merck Number	6103
Chemical Name Translation	1-甲基-3-硝基-1-亚硝基胍
Wiswesser Line Notation	WNMYUM&N1&NO
LabNetwork Molecule ID	LN01301420
InChI	InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4)

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

A DNA-damaging agent, used as a positive control in SHE cell transformation assays.

安全信息

RTECSMF4200000

GHS Symbol

Precautionary statements

P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P308+P313
P305+P351+P338
P273 Avoid release to the environment. 避免释放到环境中。
P201 Obtain special instructions before use. 使用前获取专门指示。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P332+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....
P302+P350
P337+P313
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P302+P352+P332+P313+P362+P364
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P304+P340+P312
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P305+P351+P338+P337+P313

Hazard statements

H332 Harmful if inhaled 吸入有害
H315 Causes skin irritation 会刺激皮肤
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
H319 Causes serious eye irritation 严重刺激眼睛
H350 May cause cancer 可能致癌
H228 Flammable solid 易燃固体

WGK Germany3

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Signal word Danger

Hazard Codes T;N,N,T T;N

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R45 May cause cancer 可能致癌
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R51/53
R20 Harmful by inhalation 吸入有害

UN Number 1325 2926

Storage condition 0-10 储存温度2-8℃ 0-10°C 0-6°C

Packing GroupII

Hazard Class4.1/6.1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 592 mg/kg/27W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   30,1444,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 ug/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criter

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 ug/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 651 mg/kg/34W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 28(9),34,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13500 mg/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteri

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 16,395,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1070 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   4,241,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 66 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,911,1979

{haz

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lung
DOSE/DURATION           : 1 mg/L/3H (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 12,183,1971

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 310 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 130,79,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 50 mg/L/30M (Continuous)
REFERENCE :
   JGMIAN Journal of General Microbiology.  (Soc. for General Microbiology,
   Journal Sales, 62 London Rd., Reading, RG1 5AS, UK)  V.1-    1947-
   Volume(issue)/page/year: 121,349,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 1 gm/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 31,662,1978

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 10 mg/L
REFERENCE :
   JGMIAN Journal of General Microbiology.  (Soc. for General Microbiology,
   Journal Sales, 62 London Rd., Reading, RG1 5AS, UK)  V.1-    1947-
   Volume(issue)/page/year: 128,1401,1982

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 1 mg/L
REFERENCE :
   GANNA2 G

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 50 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - cytological changes (including
   somatic cell genetic material)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 25(2),60A,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 18,263,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 25 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   3,335,1983

TYPE OF TEST            : TDLo - Lowest published toxic dos

其他信息

1-甲基-3-硝基-1-亚硝基胍价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 TM052701 1-甲基-3-硝基-1-亚硝基胍(+4℃) 5g 661元 2011/04/16 M0527 1-甲基-3-硝基-1-亚硝基胍(加约50%水湿润,本品干重约为5g) 1-Methyl-3-nitro-1-nitrosoguanidine (wetted with ca. 50% Water, containing 5g on a dry weight basis) 5G 617元
上游原料:乙醇 --> 甲醇 --> 硫酸 --> 硝酸 --> 亚硝酸钠 --> 正丁醇 --> 一甲胺 --> S-甲基异硫脲硫酸盐 --> 氰胺 --> 硝基胍 --> 1-甲基-3-硝基胍
MOL 文件:70-25-7.mol
TCI Shanghai:N-甲基-N'-硝基-N-亚硝基胍(加约50%水湿润,本品干重约为5g) N-Methyl-N'-nitro-N-nitrosoguanidine (wetted with ca. 50% Water, containing 5g on a dry weight basis),>;95.0%(T)(70-25-7)
不溶于水，保存于水中。
存储注意事项:光敏感
Sigma Aldrich:70-25-7(sigmaaldrich)