CAS 107-20-0 MFCD00006992-Chloroacetaldehyde 氯乙醛40%水溶液 TAO{mole}

Chloroacetaldehyde 氯乙醛40%水溶液

CAS 107-20-0 MFCD00006992

化学结构图

SMILES: O=CCCl

化学属性

Mol. Formula	C2 H3 Cl O
Mol. Weight	78.5
Refractive index	n20/D 1.4036
Density	1.236 g/mL at 25 °C
Flash Point	62°(143°F)
TSCA	Yes
Boiling Point
Melting Point	No Data Available
Solubility	溶于水、乙醇、乙醚、氯仿等多数有机溶剂。
Danger-Level	乙类

别名和识别编码

Chemical Name	Chloroacetaldehyde
CAS Number	107-20-0
Synonym	2-Chloracetaldehyd 2-Chlorethanal 2-Chloro-1-ethanal 2-Chloroacetaldehyde 2-Chloroethanal 2-chloro-1-ethanal[qr] 2-chloroacetaldehyde[qr] 2-氯乙醛 Acetaldehyde, chloro- Acetaldehyde,chloro- CH2ClCHO CHLOROACETALDEHYDE CLACH Chloracetaldehyd Chloro acetaldehyde Chloroacetalaldehyde Chloroacetaldehyde Chloroacetaldehyde (~45% in water) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID	33
EC Number	203-472-8
Beilstein Registry Number	1071226
MDL Number	MFCD00006992
Merck Number	14,2109
Chemical Name Translation	氯乙醛40%水溶液
Wiswesser Line Notation	VH1G
LabNetwork Molecule ID	LN01276101
InChI	InChI=1S/C2H3ClO/c3-1-2-4/h2H,1H2

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安全信息

GHS Symbol

WGK Germany3

Hazard statements

H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H330 Fatal if inhaled 吸入致命
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒
H335 May cause respiratory irritation 可能导致呼吸道刺激
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H351 Suspected of causing cancer 怀疑致癌

Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSAB2450000

Precautionary statements

P273 Avoid release to the environment. 避免释放到环境中。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P301+P310
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P303+P361+P353
P301+P310+P330
P304+P340+P310

Signal word Danger

Packing GroupI

UN Number UN2232 UN 2232 6.1/PG 1 2232

Risk Statements

R26 Very toxic by inhalation 吸入极毒
R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R35 Causes severe burns 会导致严重灼伤
R50 Very toxic to aquatic organisms 对水生生物极毒
R34 Causes burns 会导致灼伤

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Storage condition Air Sensitive No Data Available

Hazard Codes T+,N T+;N

Hazard Class6.1(a)

Restrict {} 剧毒化学品危险品

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5522 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Phar

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 267 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 61,19,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2523 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 61,19,1972

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 650 mg/m3/1H
TOXIC EFFECTS :
   Vascular - BP elevation not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory obstruction
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 200 mmol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   22,211,1978

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/plate
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 21,79,1977

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Fish - salmon Sperm
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,4804,1988

TYPE OF TES

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 5 gm/kg
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   17,239,1977

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 250 ug/plate
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   30,9,1980

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 47 mmol/L
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-

其他信息

上游原料:三氯乙烷
图谱信息:氯乙醛(107-20-0)核磁图( 13 CNMR) 氯乙醛(107-20-0)质谱(MS) 氯乙醛(107-20-0)红外图谱(IR1) 氯乙醛(107-20-0)核磁图( 1 HNMR)
职业标准:TWA 3 毫克/ 立方米
类别:有毒物质
MSDS 信息:氯乙醛(107-20-0).msds
毒性分级:高毒
MOL 文件:107-20-0.mol
下游产品:异补骨脂素 --> N-苯基-N-1,2,3-噻二唑-5-脲 --> 2-氨基噻唑 --> 5-氨基-1,2,3-噻二唑 --> 5-溴-4-氯-2-甲硫-7H-吡咯[2,3-D]嘧啶 --> 氨基乙醛缩二乙醇 --> 2-氨基-2-噻唑啉盐酸盐 --> 2-异丁基噻唑
Sigma Aldrich:107-20-0(sigmaaldrich)
爆炸物危险特性:与空气混合遇热，明火可爆炸；对皮肤,角膜有腐蚀作用
储运特性:库房通风低温干燥;与氧化剂分开存放。
可燃性危险特性:易燃; 燃烧产生有毒的氯化物气体
方法一:由氯乙烯在水中氯化而得。先向氯化反应塔加水，在40-45℃通入氯和氯乙烯反应6-7h，氯乙醛含量达9-10%时反应结束，分离副产物三氯乙烷后即为成品。商品氯乙醛为30%，40%或50%水溶液。
用途二:主要用于有机合成，如制备磺胺噻唑以及杀菌剂等。还用于使树干易脱皮。
灭火剂:干粉、泡沫、砂土
急性毒性:口服- 大鼠 LD50: 89 毫克/ 公斤; 口服- 小鼠 LD50: 82 毫克/ 公斤
用途一:用于有机合成，制取磺胺噻唑及杀菌剂等
Alfa Aesar:Chloroacetaldehyde, 45% w/w in water(107-20-0)
外观性质:40%的水溶液为无色透明的油状液体，有刺激气味。