4-Chloro-2-Phenylquinazoline 4-氯-2-苯基喹唑啉
CAS 6484-25-9 MFCD00006713
化学结构图
SMILES: Clc1nc(-c2ccccc2)nc2ccccc12
化学属性
| Mol. Formula | C14H9ClN2 |
|---|---|
| Mol. Weight | 240.69 |
| Melting Point | 124-126 °C |
| Boiling Point | 383.11 °C at 760 mmHg |
别名和识别编码
| Chemical Name | 4-Chloro-2-Phenylquinazoline |
|---|---|
| Synonym | 4-Chloro-2-phenylquinazoline {LY} 4-Chloro-2-phenylquinazoline {} {LY} 4-Chloro-2-phenylquinazoline {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chloro-2-phenylquinazoline {} {} {} {} {} {} {} {} |
| MDL Number | MFCD00006713 |
| PubChem Substance ID | 80977 |
| CAS Number | 6484-25-9 |
| EC Number | 229-346-2 |
| Chemical Name Translation | 4-氯-2-苯基喹唑啉 |
| InChIKey | OBHKONRNYCDRKM-UHFFFAOYSA-N |
| LabNetwork Molecule ID | LN00239862 |
| InChI | InChI=1S/C14H9ClN2/c15-13-11-8-4-5-9-12(11)16-14(17-13)10-6-2-1-3-7-10/h1-9H |
| Canonical SMILES | ClC=1N=C(N=C2C=CC=CC12)C=3C=CC=CC3 |
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分类
- Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Quinazolines
- {SA} Building Blocks, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Quinazolines
相关文献及参考
- 1. M. V. Papadopoulou, et al., Novel 3-nitro-1 H -1,2,4-triazole-based aliphatic and aromatic amines as anti-chagasic agents J. Med. Chem. 54 , 8214-8223, (2011)
- 2. H. M. Shallal and W. A. Russu, Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives Eur. J. Med. Chem. 46 , 2043-2057, (2011)
- 3. M. Nilsson, et al., Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents Bioorg. Med. Chem. Lett. 20 , 4004-4011, (2010)
- 4. P. M. Chandrika, et al., Synthesis leading to novel 2,4,6-trisubstituted quinazoline derivatives, their antibacterial and cytotoxic activity against THP-1, HL-60 and A375 cell lines Indian J. Chem. B 48B , 840-847, (2009)
- 5. D. Bebbington, et al., The discovery of the potent aurora inhibitor MK-0457 (VX-680) Bioorg. Med. Chem. Lett. 19 , 3586-3592, (2009)
- 6. B. Sreedhar, et al., Nanocrystalline Titania-Supported Palladium(0) Nanoparticles for Suzuki-Miyaura Cross-Coupling of Aryl and Heteroaryl Halides Adv. Synth. Catal. 353 , 2823-2836, (2011)
- 7. B. Sreedhar, et al., Catalyst-free and base-free water-promoted SNAr reaction of heteroaryl halides with thiols Synthesis 10 , 1732-1738, (2009)
- J. Org. Chem. 37 , 1681, (1972)
- J. Org. Chem. 29 , 1893, (1964)
- Fieser 4 ,86
- FT-IR 2 (3), 3948:A / FT-IR 1 (2), 881:C / FT-NMR 1 (3), 466:B / IR-Spectra (3), 1405:C / IR-Spectra (2), 1225:H / NMR-Reference 2 (2), 757:B / RegBook 1 (2), 2647:A / Structure Index 1 , 417:A:1
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352
- P304+P340
- P305+P351+P338
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
其他信息
- MOL 文件:6484-25-9.mol
- 上游原料:甲醇 --> N,N-二甲基甲酰胺 --> 三氯氧磷 --> 碳酸钾 --> 铜 --> 苄脒盐酸盐 --> 2-溴苯甲酸
- 4-氯-2-苯基喹唑啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 171931000 4-氯-2-苯基喹唑啉 4-Chloro-2-phenylquinazoline 97% 100 GR 5443元 2010/06/21 171930050 4-氯-2-苯基喹唑啉 4-Chloro-2-phenylquinazoline 97% 5 GR 530元 2010/06/21 171930250 4-氯-2-苯基喹唑啉 4-Chloro-2-phenylquinazoline 97% 25 GR 2221元
- Acros Organics:4-氯-2-苯基喹唑啉 4-Chloro-2-phenylquinazoline, 97%(6484-25-9)
- Sigma Aldrich:6484-25-9(sigmaaldrich)
