2,4,7-Triamino-6-Phenylpteridine 氨苯蝶啶
CAS 396-01-0 MFCD00006708
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- Aromatics
- Nucleotides
- Bases & Related Reagents
- Pharmaceuticals
- Intermediates & Fine Chemicals
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Monovalent Ion Channels, Other Sodium Channel Modulators, Sodium Channel Modulators, T, Voltage-gated Ion Channels, Wellspring
产品应用
- Triamterene is a weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.
相关文献及参考
- [2]. Gilfrich, H.J., et al., Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability. Eur J Clin Pharmacol, 1983. 25(2): p. 237-41.
- Kapoor, V.K., et al.: Anal. Profiles Drug Subs. Excip., 23, 571 (1994),
- Osdene, et al.: J. Med. Chem., 10, 431 (1967),
- [1]. Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6.
- [1]. Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes - underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6.
- [2]. Gilfrich, H.J., et al., Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability. Eur J Clin Pharmacol, 1983. 25(2): p. 237-41.
安全信息
GHS Symbol


- P301+P310
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H370 Causes damage to organs 导致器官损伤
- H331 Toxic if inhaled 吸入中毒
- H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
- H301 Toxic if swallowed 吞食有毒
- H311 Toxic in contact with skin 皮肤接触中毒
- H315 Causes skin irritation 会刺激皮肤
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S7 Keep container tightly closed 保存在严格密闭容器中;
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S33 Take precautionary measures against static discharges 对静电采取预防措施;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S24 Avoid contact with skin 避免皮肤接触;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
- R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
- R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 21840 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-420,1993
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 34944 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Liver - tumors REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-420,1993
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,1688,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 620 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,519,1982
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TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 42 mg/kg/3W-I TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Nutritional and Gross Metabolic - body temperature increase REFERENCE : MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914- Volume(issue)/page/year: 147,262,1987
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TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 285 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2314719
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 12600 ug/L REFERENCE : SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai Kirisutokyo Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new numbering in 1976. Volume(issue)/page/year: (20),574,1980
TYPE OF TEST : Morphological transformation TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 25 mg/L REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 6),4,1986
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 2800 ug/L REFERENCE : GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981
TYPE OF TEST : Micronucleus test TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 12600 ug/L REFERENCE : SNSHBT Senshokutai. Chromosome. (Sensyokutai Gakkai, Kaokusai Kirisutokyo Daigaku, Mitaka, Tokyo-to, Japan) No.1- 1946- Adopted new numbering in 1976. Volume(issue)/page/year: (20),574,1980
其他信息
- 上游原料:氰乙酸乙酯 --> 乙醇钠 --> 乙二胺四乙酸二钠盐 --> 氰苄 --> 2,4,6-三氨基嘧啶
- TCI Shanghai:氨苯蝶啶 Triamterene,>;98.0%(T)(396-01-0)
- 图谱信息:2,4,7-三氨基-6-苯基蝶啶(396-01-0)红外图谱(IR1) 2,4,7-三氨基-6-苯基蝶啶(396-01-0)质谱(MS) 2,4,7-三氨基-6-苯基蝶啶(396-01-0)红外图谱(IR2)
- 方法一:5-亚硝基-2,4,6-三氨基嘧啶和无水乙醇一起回流1h,加入部分量氰苄和乙醇钠,回流2h后再加入其余量氰苄和乙醇钠,继续回流5h,冷却至10℃左右,过滤,用沸水洗涤,得氨苯蝶啶粗品。将粗品、浓硫酸及活性炭加入水中,回流45min,趁热过滤,滤液加热至沸,加入ED-TA二钠盐,用浓氨水调节至pH9,过滤,洗涤,干燥,得成品。
- MSDS 信息:2,4,7-Triamino-6-phenylpteridine(396-01-0).msds
- 用途一:弱效利尿药。作用迅速而短暂,口服后2h开始利尿,6h达高峰,作用持续8-12h,临床用于心力衰竭,肝硬化和慢性肾炎等引起的顽固性水肿或腹水,亦用于对氢氯噻嗪 或螺内酯无产的病例。该品有排除尿酸作用,适用于治疗痛风。
- Sigma Aldrich:396-01-0(sigmaaldrich)
- Alfa Aesar:2,4,7-三氨基-6-苯基蝶啶,98% 2,4,7-Triamino-6-phenylpteridine, 98%(396-01-0)
- MOL 文件:396-01-0.mol
- 氨苯蝶啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 B20044 2,4,7-三氨基-6-苯基蝶啶, 98% 2,4,7-Triamino-6-phenylpteridine, 98% 5g 412元 2010/05/25 B20044 2,4,7-三氨基-6-苯基蝶啶, 98% 2,4,7-Triamino-6-phenylpteridine, 98% 25g 853元 2010/05/25 B20044 2,4,7-三氨基-6-苯基蝶啶, 98% 2,4,7-Triamino-6-phenylpteridine, 98% 100g 2730元