CAS 123-33-1 MFCD00006665-3,6-Dihydroxypyridazine 顺丁烯二酰肼 TAO{mole}

3,6-Dihydroxypyridazine 顺丁烯二酰肼

CAS 123-33-1 MFCD00006665

化学结构图

SMILES: O=c1ccc(=O)[nH][nH]1

化学属性

Mol. Formula	C4H4N2O2
Mol. Weight	112.09
Melting Point	299-301°C
Density	1.6
Flash Point	300°C
TSCA	Yes
Autoignition Point	707 °F
Solubility	6 G/L
Stability	对湿度敏感
Boiling Point	209.98 °C at 760 mmHg

别名和识别编码

Chemical Name	3,6-Dihydroxypyridazine
Synonym	Maleic hydrazide {LY} Maleic hydrazide {} {LY} Maleic hydrazide {} {} {LY} Maleic hydrazide {} {} {} {LY} Maleic hydrazide {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Maleic hydrazide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number	MFCD00006665
PubChem Substance ID	21954
Beilstein Registry Number	24,312
CAS Number	123-33-1
EC Number	204-619-9
Reaxys-RN	112223
Merck Number	5705
Alfabeta Name	DIHYDROPYRIDAZINEDIONE 1236---,,
Chemical Name Translation	顺丁烯二酰肼
InChIKey	BGRDGMRNKXEXQD-UHFFFAOYSA-N
Wiswesser Line Notation	T6VMMVJ
InChI	InChI=1S/C4H4N2O2/c7-3-1-2-4(8)6-5-3/h1-2H,(H,5,7)(H,6,8)
Canonical SMILES	O=C1C=CC(NN1)=O

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品牌质保精细包装现货库存一流品牌服务

产品应用

马来酰肼为选择性除草剂和暂时性植物生长抑制剂。

安全信息

GHS Symbol

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P332+P313
P305+P351+P338
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P305+P351+P338+P337+P313
P302+P350
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P337+P313
P302+P352+P332+P313+P362+P364

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H228 Flammable solid 易燃固体
H303 May be harmfully swallowed 吞食可能有害

Hazard Codes Xn Xi,Xn

WGK Germany2

RTECSUR5950000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Signal word Warning {} {} {} {} {TCI}

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

UN Number UN 3077 9/PG 3 3077

Warnings IRRITANT

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2600 mg/kg/65W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   19,392,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >20 gm/m3
TOXIC EFFECTS :
   Details

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - quail
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,526,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 9,119,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PEMNDP Pesticide Manual.  (The British Crop Protection Council, 20 Bridport
   Rd., Thornton Heath CR4 7QG, UK)  V.1-    1968-  Volume(issue)/page/year:
   9,526,1991

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/disc
REFERENCE :
   JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food
   Contaminants, and Agricultural Wastes.  (Marcel Dekker, 270 Madison Ave.,
   New York, NY 10016)  V.B11-    1976-  Volume(issue)/page/year: 21,319,1986

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 67,249,1979

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Scien

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 24,460,1986

TYPE OF T

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 344,41,1995

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 4000 ppm
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 207,439,1965

其他信息

Acros Organics:马来酰肼 3,6-Dihydroxypyridazine, 99%(123-33-1)
可燃性危险特性:燃烧产生有毒氮氧化物气体
毒性分级:中毒
方法二:由顺丁烯二酸酐与水合肼反应而得。在反应锅中投入水及40%水合肼，搅拌冷却下滴加30%盐酸，温度控制在20℃以下，至pH值为6.2-6.4，投入顺丁烯二酸酐，缓缓升温至106-110℃，回流2h，降温至5℃，甩滤，滤饼用冰水洗至pH4.8-5.1，干燥，得顺丁烯二酰肼，收率97%。
TCI Shanghai:顺丁烯二酸肼 Maleic Hydrazide,>;98.0%(LC)(T)(123-33-1)
顺丁烯二酰肼价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30111424 顺丁烯二酰肼 25g 35元 2011/08/23 30111460 顺丁烯二酰肼 25g
注意事项:[1]本品喷洒过的作物、饲料不能喂饲牲畜，喷洒区内不能放牧。 [2]应贮存于阴凉干燥处
灭火剂:干粉、泡沫、砂土
MOL 文件:123-33-1.mol
MSDS 信息:马来酰肼(123-33-1).msds
下游产品:3,6-二氯哒嗪 --> 磺胺二甲基嘧啶
Sigma Aldrich:123-33-1(sigmaaldrich)
方法一:由丁烯二酸酐（或丁二烯二酸）与硫酸肼于35～56℃下反应制得。
毒性:大鼠急性经口LD 50 1400mg/kg，其钠盐为6950mg/kg，二乙醇盐为2340mg/kg。无刺激作用。用含5%原药的饲料喂养大鼠2年未出现中毒症状，未见致畸、致癌、致突变性。对鱼低毒，鲈鱼LC 50 75mg/L。对蜜蜂无毒。
海关编码:29339990
微溶于冷水，溶于热水、热碱液，不溶于醚、氯仿。
上游原料:水合肼 --> 水合肼 --> 马来酸酐
外观性质:白色结晶体。
Alfa Aesar:马来酰肼,97% Maleic hydrazide, 97%(123-33-1)
储运特性:库房通风低温干燥; 与食品原料分开储运
用途三:植物生长调节剂。通过叶面或根部吸入，由木质部和韧皮部传导，抑制细胞分裂而抑制植物生长。0.1%～0.05%药液可防除禾草和草坪、果园及水边杂草；0.025%药液抑制洋葱和马铃薯贮存期发芽；0.1%～0.05%药液抑制及延缓烟草侧芽生长和保持柑橘苗免受霜害。
用途四:顺丁烯二酰肼为选择性除草剂和暂时性植物生长抑制剂。药剂可通过叶面角质层进入植株，降低光合作用、渗透压和蒸发作用，能强烈地抑制芽的生长。用于防止土豆、洋葱、大蒜和萝卜贮藏期发芽，并有抑制作物生和延长开花的作用，也可用于非耕地除草。该品的互变异构为3，6-二羟基哒嗪（3，6-Dihydroxypyridazine）。是磺胺类药物磺胺甲氧嗪的中间体。
类别:农药
用途五:顺丁烯二酰肼为选择性除草剂和暂时性植物生长抑制剂。药剂可通过叶面角质层进入植株，降低光合作用
用途六:暂时性植物生长抑制剂。选择性除草剂(能除去马唐草)。防止贮藏中的洋葱、土豆和胡萝卜发芽。园艺与农业实验。顺丁烯二酰肼为选择性除草剂和暂时性植物生长抑制剂。药剂可通过叶面角质层进入植株，降低光合作用、渗透压和蒸发作用，能强烈地抑制芽的生长。用于防止土豆、洋葱、大蒜和萝卜贮藏期发芽，并有抑制作物生和延长开花的作用，也可用于非耕地除草。该品的互变异构为3，6-二羟基哒嗪（3，6-Dihydroxypyridazine）。是磺胺类药物磺胺甲氧嗪的中间体。
检测方法:HPLC
图谱信息:顺丁烯二酰肼(123-33-1)红外图谱(IR2) 顺丁烯二酰肼(123-33-1)核磁图( 13 CNMR) 顺丁烯二酰肼(123-33-1)红外图谱(IR1