CAS 98-92-0 MFCD00006395-Nicotinamide 烟酰胺 TAO{mole}

Nicotinamide 烟酰胺

CAS 98-92-0 MFCD00006395

化学结构图

SMILES: NC(=O)C1CCCNC1

化学属性

Mol. Formula	C6H6N2O
Mol. Weight	122.12
Melting Point	130°C
Density	1.4
Flash Point	156.0±20.4°C
TSCA	Yes
Boiling Point	334.4±15.0°C at 760 mmHg
Solubility	Soluble in water (1000 g/l) at 20 °C, ethanol (100 mM), glycerol (1 g/10ml), DMSO (100 mM), methanol, butanol, chloroform, and ether (Slightly).
Appearance	白色针状结晶或结晶性粉末，无臭或稍有臭气，味微苦。相对密度1.4，熔点129-131℃。1g本品可溶于1mL水、1.5mL乙醇或10mL甘油，不溶于乙醚。10%的水溶液的PH为6.5-7.5。在干燥空气中对光、热均稳定，在碱性或酸性溶液中加热则生成烟酸。大白鼠经口LD powder 2.5-3.5g/kg，ADI值不作特殊规定（ECC，1990） 50
Stability	对光线敏感

别名和识别编码

Chemical Name	Nicotinamide
CAS Number	98-92-0
Synonym	Nicotinamide {LY} Nicotinamide {} {LY} Nicotinamide {} {} {LY} Nicotinamide {} {} {} {LY} Nicotinamide {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nicotinamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY}
PubChem Substance ID	936
EC Number	202-713-4
Beilstein Registry Number	383619
MDL Number	MFCD00006395
Reaxys-RN	383619
Merck Number	6523
Chemical Name Translation	烟酰胺
Wiswesser Line Notation	T6NJ CVZ
LabNetwork Molecule ID	LN00195184
InChI	InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
Canonical SMILES	O=C(C1=CC=CN=C1)N

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

生化研究，配制组织培养基。

安全信息

GHS Symbol

WGK Germany1

Hazard Codes Xi

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H303 May be harmfully swallowed 吞食可能有害

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

RTECSQS3675000

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338
P305+P351+P338+P337+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P332+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用

Signal word Warning

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,1390,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2050 mg/kg
TOXIC E

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1680 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 62,19,1946

TYPE OF

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2050 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 109,479,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 20 mmol/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 69,1353,1982

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   NULSAK Nucleus (Calcutta).  (Dr. A.K. Sharma, Centre of Advanced Studies in
   Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta
   700 019, India)  V.1-    1958-  Volume(issue)/page/year: 28,198,1985

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 126,63,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 mg/plate
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 37,447,1986

TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - rat Ovary
DOSE/DURATION           : 25 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 143,263,1985

其他信息

所属类别二:食品添加剂: 营养强化剂: 维生素类
参考质量标准二:FCC，1997 含量(干燥后) 98.5%～101.0% 重金属(以Pb计，GT-16-2) ≤0.002% 干燥失重(在硅胶上4h) ≤0.5% 熔程 128～131℃ 易炭化物试验阴性灼烧残渣(GT-27) ≤0.1%
下游产品:烟酸
{Chemical
无臭或几乎无臭，味苦，易溶于水和乙醇，溶于甘油，溶解度: 1000 g/L 水(20°C) ，1g/1.5ml 乙醇， 1g/10ml 甘油。
烟酰胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 67000934 烟酰胺 25g 15.2元 2011/08/23 SN337601 烟酰胺 100g 204元 2011/04/16 N0078 烟酰胺 Nicotinamide 25G 109元
图谱信息:烟酰胺(98-92-0)质谱(MS) 烟酰胺(98-92-0)核磁图( 13 CNMR) 烟酰胺(98-92-0)红外图谱(IR2) 烟酰胺(98-92-0)红外图谱(IR1) 烟酰胺
上游原料:氢氧化铵 --> 氨 --> 4-氯苯甲醛 --> 烟酸 --> 3-氰基吡啶 --> 3-甲基吡啶
用途四:生化研究；组织培养基的营养成分；临床药物为维生素B族，用于防治糙皮病及口炎、舌炎等病症的治疗。
用途三:与烟酸相同。水溶性较烟酸好，但易与维生素C生成复合物而结块。用量30-80
用途六:生化研究，配制组织培养基。
使用限量:GB 14880—94：同“01017，烟酸”。以GMP为限(FDA§184.1535，2000)。日本(1998)：小麦粉35mg/kg；大米7mg/kg；改质奶粉4mg/kg；肉的发色助剂0.02%～0.1%(与维生素C合用)。保持和增强火腿、香肠的色、香、味。不得用于食肉及鲜鱼贝类、鲸肉。
用途二:维生素类药，参与体内代谢过程，用于防治糙皮病等烟酸缺乏症
方法一:将烟酸、硼酸和氨水投入反应锅，搅拌下通入氨气，升温溶解，然后蒸馏回收氨，至120℃后移入脱水锅内继续浓缩，当温度达到145℃后开始加入液氨，并在185-190℃下继续通氨反应20-30h。然后降温至130℃，加蒸馏水稀释，加入活性炭，并在70-80℃通氨脱色2h，反应后趁热过滤，滤液在水中冷析24h，分离结晶，并用乙醇洗涤、干燥得成品，收率89%
所属类别四:饲料添加剂: 维生素添加剂
所属类别三:食品添加剂: 营养强化剂（营养增补剂）: 维生素
color:white
方法二:β-甲基吡啶经空气氧化成烟酸，后者与氢氧化铵作用，再加热脱水制得。
方法三:将烟酸、硼酸和氨水投入反应锅，搅拌下通入氨气，升温溶解；然后蒸馏回收氨，至120~C后移入脱水锅内继续浓缩；当温度达145℃后开始加入液氨，并在185～190℃下继续通氨反应20～30h。然后降温至130℃，加蒸馏水稀释，加入活性炭，并在70~80~C下通氨脱色2h；反应后趁热过滤，滤液在水中冷析24h，分离结晶，并用乙醇洗涤、干燥得成品，收率89%。
所属类别一:生物化学品: 生化试剂: 辅酶和维生素
毒性:LD 50 2.5～3.5g/kg(大鼠，经口)。 GRAS(FDA，§182.5535，2000)。 ADI不作特殊规定(EEC，1990)。
Nicotinamide is a NAD+ and NADP+ coenzyme precursor. Nicotinamide is an antiinflammatory agent and a PARP-1 enzyme
图
用途五:烟酰胺和烟酸在大多数声合下通用，烟酸在动物体内也生成烟酰胺。体内缺乏烟酸和烟酰胺时，会得糙皮病。因此它们可预防糙皮病。它们在蛋白质和糖的新陈代谢中起作用，可改善人类和动物的营养。除用作医药外，还大量用作食品和饲料添加剂。全世界的生产能力已