CAS 109-06-8 MFCD00006332-2-Methylpyridine 2-甲基吡啶 TAO{mole}

2-Methylpyridine 2-甲基吡啶

CAS 109-06-8 MFCD00006332

化学结构图

SMILES: CC1CCCCN1

化学属性

Mol. Formula	C6H7N
Mol. Weight	93.13
Density	0.943
Refractive index	1.4970 to 1.5030
Autoignition Point	995 °F
Vapor Density	3.2 (vs air)
Boiling Point	128°C
Vapor Pressure	10 mmHg ( 24.4 °C)
Melting Point	-70
Flash Point	25°C(lit.)
TSCA	Yes
Solubility	与水混溶，溶于多数有机溶剂。
Stability	对光敏感

别名和识别编码

Chemical Name	2-Methylpyridine
CAS Number	109-06-8
EC Number	203-643-7
Beilstein Registry Number	20,234
MDL Number	MFCD00006332
Synonym	2-甲基呲啶 2-甲基吡啶 α-picoline o-Methylpyridine .alpha.-Methylpyridine 2-Methylpyridine-d7(2-Picoline),98 atom % D Pyridine, 2-methyl- pyridine,2-methyl- o-Methylpyridine aPicolin α-甲代氮苯 2-Methylpyidine 2-methyl-pyridine Rcra waste number U191 a-Methylpyridine 2-皮考林 pyridine, 2-methyl- α-Picoline 2-甲基吡啶 PICOLINE, alpha ALPHAP alpha-Methylpyridine 2-picoline ALPHA-PICOLINE Picoline α-Methylpyridine o-picoline(2-methylpyridine) rcrawastenumberu191 ai3-2409 α-甲基吡啶,2-皮考啉,α-甲代氮苯 α-甲基吡啶 {
PubChem Substance ID	7975
Merck Number	7400
Chemical Name Translation	2-甲基吡啶
Reaxys-RN	104581
Wiswesser Line Notation	T6NJ B1
LabNetwork Molecule ID	LN00220344
InChI	InChI=1S/C6H7N/c1-6-4-2-3-5-7-6/h2-5H,1H3

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产品应用

检定钴、氰酸盐和铁。有机合成。

安全信息

Signal word Danger

GHS Symbol

WGK Germany1

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
R10 Flammable 易燃
R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
R24 Toxic in contact with skin 与皮肤接触有毒
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

Precautionary statements

P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P403+P233
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P301+P330+P331+P310
P303+P361+P353
P201 Obtain special instructions before use. 使用前获取专门指示。
P241+P242+P243
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P305+P351+P338+P310
P304+P340+P310
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P233 Keep container tightly closed. ?保持容器密闭。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P308+P311
P303+P361+P353+P310+P363
P405 Store locked up. 上锁保管。

Hazard statements

H226 Flammable liquid and vapour 易燃液体和蒸气
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H302+H332
H311 Toxic in contact with skin 皮肤接触中毒
H332 Harmful if inhaled 吸入有害
H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSTJ4900000

Packing GroupIII

UN Number UN2313 2313

Hazard Codes T

Hazard Class3

Storage condition Flammables area 密封阴凉避光保存。

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 674 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(12),62,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 790 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(12),62,1980

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(is

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9 gm/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   V

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 7400 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 163,23,1986

Restrict 危险品

其他信息

用途一:用作合成医药、染料、树脂的原料，可制取化肥增效剂、除草剂、牲畜驱虫剂、橡胶促进剂、染料中间体等
毒性分级:中毒
有极不愉快的气味。能与乙醇、乙醚混溶，易溶
{Chemical
蒸气压:10 mm Hg ( 24.4
{Chemica
灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
爆炸物危险特性:与空气混合可爆
上游原料:硫酸 --> 氨 --> 苯 --> 丙烯腈 --> 硫酸铵 --> 丙烯醛 --> 4-甲
TCI Shanghai:2-甲基吡啶 2-Picoline,>;98.0%(GC)(T)(109-06-8)
MSDS 信息:2-甲基吡啶(109-0
MOL 文件:109-06-8.mol
2-甲基吡啶价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80103628 2-甲基吡啶;α-甲基吡啶; 2-皮考啉;α-噼口哥啉; α-煤膏啶 500ml 94元 2011/08/23 xp4003
方法一:其制备方法是以乙醛为原料，与氨气在催化剂存在下气相反应，反应
类别:易燃液体
上游原料:硫酸 --> 氨 --> 苯 -->
敏感性:Hygroscopic
Acros Org
图谱信息:2-甲基吡啶(109-06-8)红外图谱(IR3) 2-甲基吡啶(109-06-8)核磁图( 1 HNMR) 2-甲基吡啶(109-06-8)红外图谱(IR2) 2-甲基吡啶(109-06-8)核磁图( 13 CNMR) 2-甲基吡啶(109-06-8)质谱(MS) 2
Alfa Aesar:2-甲基吡啶,98+% 2-Picoline, 98+%(109-06-8)
用途五:检定钴、氰酸盐和铁。有机合成。
方法二:吡啶和甲基吡啶以前都从煤焦化副产中回收，它分布在焦炉煤气、粗苯和焦油中。一般从煤气转移到硫铵母液里的吡啶类水合物沸点都很低，在95-97℃之间，回收得到的粗轻吡啶盐基中，2-甲基吡啶含15%左右，进一步精馏可切取得到2-甲基吡啶。随着吡啶和甲基吡啶用途的扩大，合成法生产吡啶和甲基吡啶不断发展。目前，国外约95%的吡啶及吡啶类化合物是用合成法生产的。主要的合成法有乙醛法、乙炔法、丙烯腈法等。乙醛法乙醛、甲醛和氨反应，主要产品是2-甲基吡啶、3-甲基吡啶和4-甲基吡啶。乙炔法乙炔和氨反应，主要产品是2-甲基吡啶和4-甲基吡啶。乙烯法乙烯和氨反应，主要产品是2-甲基吡啶和2-甲基-5-乙基吡啶。丙烯腈法丙烯腈和过量丙酮反应，主要产品是2-甲基吡啶。另外，丙烯醛和氨反应主要生成3-甲基吡啶。
下游产品:3-氨基-6-甲基吡啶 --> 2-氨基6-甲基吡啶 --> 2-甲基-4-羧基吡啶 --> 吡啶-2-甲醛 --> 4-甲氧基吡啶-2-甲酸 --> 5-羟基-2-吡啶羧酸 --> 4-羟基吡啶-2-羧酸 --> 4-溴吡啶-2-羧酸 --> 4-硝基-2-甲酸吡啶 --> 4-氯-2-吡啶甲酸 --> 2,2'-联吡啶 --> (±)-4-甲氧基-N-[2-[2-(1-甲基-2-哌啶基)乙基]苯基]苯甲酰胺 --> N-甲基-N-2-(2-吡啶基)胺 --> 氯霉素棕榈酸酯 --> 马来酸氯苯那敏 --> 2-丙醇吡啶 --> 2-(2-吡啶)-苯并咪唑 --> 2-氯甲基吡啶盐酸盐 --> 吡啶醇 --> 2-(溴甲基)吡啶氢溴酸盐 --> 2-吡啶乙肪醛甲碘化物 --> 2-吡啶醛肟甲氯 --> 4-(2-吡啶甲基)苯胺 --> 异丁司特 --> {[(6-甲基-2-吡啶基)氨基]亚甲基}丙二酸二乙酯 --> 比沙可啶 --> 碘化1,2-二甲基吡啶鎓
刺激数据:皮肤- 兔子 10 毫克/ 24小时轻度; 眼睛- 兔子 0
Acros Organics:2-甲基吡啶 2-Picoline, 98%(109-06-8)