5-Amino-2,4(1H,3H)-pyrimidinedione 5-氨基-2,4(1H,3H)-嘧啶二酮

CAS 932-52-5 MFCD00006025

化学结构图

932-52-5
SMILES: NC1=CNC(=O)NC1=O

化学属性

Mol. FormulaC4H5N3O2
Mol. Weight127
Density1.422
Melting Point>300
TSCAYes
Solubility0.5 G/L (20 ºC)

别名和识别编码

Chemical Name5-Amino-2,4(1H,3H)-pyrimidinedione
Synonym -Amino-2,4-pyrimidinediol 2,4-Dihydroxy-5-aminopyrimidine 3h)-pyrimidinedione,5-amino-4(1h 5-AMINO-2,4-DIHYDROXYPYRIMIDINE 5-AMINO-2,4-DIHYDROXYPYRIMIDINE[5-2,6] 5-AMINO-2,4-PYRIMIDINEDIOL 5-Amino-1H-pyrimidine-2,4-dione 5-Amino-2,4(1H,3H)-pyrimidinedione 5-Amino-2,4-dihydroxypyrimidine 5-Amino-2,4-dihydroxypyrimidine, 5-Amino-2,4-pyrimidinediol 5-Amino-2,4-dihydroxypyrimidine,5-Amino-2,4-pyrimidinediol 5-Amino-2,4-pyrimidinediol 5-Amino-2,4-pyrimidinediol; 5-Amino-2,4-dihydroxypyrimidine 5-Aminopyrimidine-2,4(1H,3H)-dione 5-Aminouracil 5-Aminouracil ,98% 5-Aminouracil,97% 5-amino-1H-py 5-amino-uraci 5-氨基-2,4-二羟基嘧啶 5-氨基-2,4-二羟基嘧啶 5-氨基-2,4-嘧啶二醇 5-氨基-2,6-二羟基嘧啶 5-氨基尿
MDL NumberMFCD00006025
CAS Number932-52-5
EC Number213-252-3
Beilstein Registry Number127250
PubChem Substance ID87562407
Reaxys-RN127250
Chemical Name Translation5-氨基-2,4(1H,3H)-嘧啶二酮
Wiswesser Line NotationT6MVMVJ EZ
LabNetwork Molecule IDLN00243291
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分类

  • {SNA} Building Blocks, C4 to C5, Chemical Synthesis, Heterocyclic Building Blocks, Pyrimidines
  • {uni_hamburg} no charge; nitrogen heterocycle; 6RingOnly; 6ring; urea; amide; lactame; 1fragment

产品应用

  • 用作生化研究试剂

相关文献及参考

  • Condensation with crotonaldehyde gives 2,4-dioxo-6-methylpyrido[3,2-d]pyrimidine: J. Chem. Soc. (C), 1745 (1967). An improved procedure has been used in synthesis of inhibitors of human thymidylate synthase: J. Med. Chem., 27, 1710 (1984), and of dihydrofolate reductases: J. Med. Chem., 39, 1836 (1996):
  • Short: III/20a
  • Short: EINECS
  • Review of the use of uracils as starting materials in heterocyclic synthesis: Adv. Heterocycl. Chem., 55, 130 (1992).

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P301+P312+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
RTECSYQ8740000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   RAREAE Radiation Research.  (Academic Press, Inc., 1 E. First St., Duluth,
   MN 55802)  V.1-    1954-  Volume(issue)/page/year: 37,334,1969

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 300 mg/L
REFERENCE :
   JGMIAN Journal of General Microbiology.  (Soc. for General Microbiology,
   Journal Sales, 62 London Rd., Reading, RG1 5AS, UK)  V.1-    1947-
   Volume(issue)/page/year: 18,543,1958

其他信息

  • TCI Shanghai:5-氨基尿嘧啶 5-Aminouracil,>;98.0%(LC)(932-52-5)
  • 上游原料:盐酸 --> 氨 --> 连二亚硫酸钠 --> 5-硝基尿嘧啶
  • Alfa Aesar:5-氨基脲嘧啶,97% 5-Aminouracil, 97%(932-52-5)
  • F:10-23
  • 储运特性:库房通风低温干燥
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • 毒性分级:中毒
  • MSDS 信息:5-Aminouracil(932-52-5).msds
  • 可燃性危险特性:可燃;高温产生有毒氮氧化物烟雾
  • Sigma Aldrich:932-52-5(sigmaaldrich)
  • 5-氨基尿嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A0898 5-氨基尿嘧啶 5-Aminouracil 5G 539元 2014/06/02 A0898 5-氨基尿嘧啶 5-Aminouracil 25G 1500元 2010/06/21 226820025 5-氨基尿嘧啶 5-Aminouracil 98% 2.5 GR 253元
  • 图谱信息:5-氨基尿嘧啶(932-52-5)红外图谱(IR2) 5-氨基尿嘧啶(932-52-5)质谱(MS) 5-氨基尿嘧啶(932-52-5)红外图谱(IR1)
  • 用途一:用作生化研究试剂
  • 检测方法:HPLC
  • 急性毒性:参考值: 非肠道-小鼠LDL0: 2400 毫克/公斤
  • Acros Organics:5-氨基尿嘧啶 5-Aminouracil, 98%(932-52-5)
  • MOL 文件:932-52-5.mol
  • 溶于稀酸,不溶于水。具两性。可形成金属盐和苦味酸盐
  • 外观性质:针状结晶,溶于稀酸,不溶于水。具两性。可形成金属盐和苦味酸盐熔点:>300 °C
  • 类别:有毒物品

系列性分类


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