8-Bromo-Camp Sodium Salt 8-溴腺苷-3,5-环单磷酸钠

CAS 76939-46-3 MFCD00005844

化学结构图

76939-46-3
SMILES: [Na+].NC1N=CN=C2C=1N=C(Br)N2[C@@H]1O[C@@H]2COP([O-])(=O)O[C@H]2[C@H]1O

化学属性

Mol. FormulaC10H10BrN5NaO6P
Mol. Weight430

别名和识别编码

Chemical Name8-Bromo-Camp Sodium Salt
Synonym 8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt 8-溴腺苷-3′,5′-环单磷酸 钠盐 8-Br-cAMP
MDL NumberMFCD00005844
PubChem Substance ID24278020
Beilstein Registry Number7739743
CAS Number76939-46-3
Chemical Name Translation8-溴腺苷-3,5-环单磷酸钠
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分类

  • {SNA} B, Bioactive Small Molecule Alphabetica
  • {SA} Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides
  • {SNA} B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Protein Kinase A (PKA),
  • B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Kinase/Phosphatase Biology, Protein Kinase A (PKA), Serine/Threonine Kinase Activators, Serine/Threonine Kinase Biology

相关文献及参考

  • Hsueh, R.C., et al., Deciphering Signaling Outcomes From A System Of Complex Networks. Science Signaling 2 , ra22, (2009) 摘要
  • Semple, F., et al., Human Beta-defensin 3 Has Immunosuppressive Activity In Vitro And In Vivo. Eur. J. Immunol. 40 , 1073-8, (2010) 摘要
  • Chen, M.C., et al., Involvement Of CAMP In Nerve Growth Factor-triggered P35/Cdk5 Activation And Differentiation In PC12 Cells. Am. J. Physiol. Cell Physiol. 299 , C516-27, (2010) 摘要
  • Giusti, C., et al., Autophagic Cell Death In Dictyostelium Requires The Receptor Histidine Kinase DhkM. Molecular Biology of the Cell 21 , 1825-35, (2010) 摘要
  • Meyer, R.B. Jr., and Miller, J.P., Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity. Life Sci. 14 , 1019-1040, (1974)
  • Hei, Y.J., et al., Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol. Pharmacol. 39 , 233, (1991) 摘要
  • Martin, T.F., and Kowalchyk, J.A., Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage. Science 213 , 1120-1122, (1981) 摘要
  • Chen, T.C., et al., Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest. 78 , 165-174, (1998) 摘要

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。

系列性分类


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