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分类

• {SNA} Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, DIG-DY, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
• {SNA} Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors, 细胞生物学
• {SA} Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors
• {SNA} Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Phosphodiesterase Inhibitors

相关文献及参考

• [2]. Yosry El-said, et al. In-vitro evaluation of sustained-release dyphylline tablets. Drug Development and Industrial Pharmacy. Volume 17, 1991 - Issue 2
• Merck: 14,3479
• Merck: 14,3479 Beilstein: 26,IV,2370
• [1]. Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.
• [1]. Schwabe U, et al. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21.
• [2]. Yosry El-said, et al. In-vitro evaluation of sustained-release dyphylline tablets. Drug Development and Industrial Pharmacy. Volume 17, 1991 - Issue 2

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Let

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1052 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 6,601,1956

TYPE OF TEST            : LD5

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 35,266,1946

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 195 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   STRAAA Strahlentherapie.  (Urban & Schwarzenberg, Postfach 202440, D-8000
   Munich 2, Fed. Rep. Ger.) V.1-    1912-  Volume(issue)/page/year:
   127,245,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1080 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
   York, NY)  V.1-3, 1964-72.  Discontinued.  Volume(issue)/page/year:
   2,288,1970

其他信息

• 二羟丙茶碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 115055000 二羟丙茶碱 7-(2,3-Dihydroxypropyl)theophylline 99% 500 GR 2522元 2010/06/21 115051000 二羟丙茶碱 7-(2,3-Dihydroxypropyl)theophylline 99% 100 GR 890元
• 方法一:由茶碱钠盐与一氯丙二醇经缩合而得。
• Acros Organics:7-(2,3-二羟丙基)茶碱 7-(2,3-Dihydroxypropyl)theophylline, 99%(479-18-5)
• 用途二:本品与氨茶碱同属黄嘌呤类扩张支气管药，适用于治疗支气管哮喘、喘息性支气管炎及慢性肺气肿等，也可用于预防支气管哮喘发作，还可用于心绞痛及心脏性水肿的治疗。茶碱是黄嘌呤类药物的代表性品种，为了改善茶碱的溶解度而发展出氨茶碱（茶碱与乙二胺的复盐）、胆茶碱（茶碱与胆碱的复盐）、二羟丙茶碱（茶碱N-7位衍生物）等。二羟丙茶碱水溶性较氨茶碱大，但作用较茶碱弱，其毒性约为氨茶碱的1/5。鼠口服LD50为3400毫克/公斤。
• 图谱信息:二羟丙茶碱(479-18-5)红外图谱(IR1) 二羟丙茶碱(479-18-5)红外图谱(IR2)
• 无臭，味苦；遇光易变质。易溶于水，微溶于乙醇。水溶液pH为6．5—7．4，10．87％水溶液为等渗溶液。溶解度：1g/3ml 水(25 C)、2g/100ml 乙醇和1g/100ml 氯仿。
• 上游原料:丙二醇 --> 茶碱钠盐
• MSDS 信息:Diprophylline(479-18-5).msds
• Sigma Aldrich:479-18-5(sigmaaldrich)
• 用途一:有扩张支气管和冠状动脉的作用，并有利尿作用。
• 检测方法:HPLC,NMR
• MOL 文件:479-18-5.mol