4-Hydroxyindole 4-羟基吲哚

CAS 2380-94-1 MFCD00005667

化学结构图

2380-94-1
SMILES: Oc1cccc2[nH]ccc12

化学属性

Mol. FormulaC8H7NO
Mol. Weight133.15
Melting Point97-99°C
Density1.327
TSCANo
Solubility略溶于水
Boiling Point343.2°C at 760 mmHg

别名和识别编码

Chemical Name4-Hydroxyindole
CAS Number2380-94-1
Alfabeta NameHYDROXYINDOLE 4-
MDL NumberMFCD00005667
Synonym 4-Hydroxyindole {LY} 4-Hydroxyindole {} {LY} 4-Hydroxyindole {} {} {LY} 4-Hydroxyindole {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Hydroxyindole {} {} {} {} {} {} {} {} {} {} {} {} {}
EC Number219-177-2
Beilstein Registry Number114905
PubChem Substance ID87570967
Reaxys-RN114905
Chemical Name Translation4-羟基吲哚
LabNetwork Molecule IDLN00224101
InChIInChI=1S/C8H7NO/c10-8-3-1-2-7-6(8)4-5-9-7/h1-5,9-10H
Canonical SMILESOC1=CC=CC2=C1C=CN2
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分类

  • {SNA} Building Blocks, C7 to C9, Chemical Synthesis, Heterocyclic Building Blocks, Indoles
  • Heterocycles
  • Indole Derivatives

产品应用

  • Pindolol (P468000) impurity.

相关文献及参考

  • Beilstein:21(3/4)764
  • Ohia, S., et al.: Pharmacol. Exp. Ther., 255, 11

安全信息

Warnings IRRITANT, KEEP COLD
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Storage condition 2-8°C, protect from light, stored under nitrogen {LY} 2-8°C, protect from light, stored under nitrogen {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitr

其他信息

  • 检测方法:HPLC
  • 方法一:以间苯二酚为原料，经异构化、催化氢化，再用溴代丙酮酸乙酯环合制得4-氧代四氢古马龙羧酸。将其加入经氨饱和的甲醇溶液中，在高压釜加热反应，生成4-氧代四氢吲哚。最后经脱氢、异构化制得4-羟基吲哚。
  • Sigma Aldrich:2380-94-1(sigmaaldrich)
  • Acros Organics:4-Hydroxyindole, 99%(2380-94-1)
  • 用途一:用作医药中间体
  • Alfa Aesar:4-羟基吲哚,98% 4-Hydroxyindole, 98%(2380-94-1)
  • MOL 文件:2380-94-1.mol
  • 上游原料:叔丁醇 --> 多聚甲醛 --> 间苯二酚 --> N,N-二甲基乙酰胺 --> 吲哚 --> 甲醇溶液 --> 3-溴丙酮酸乙酯 --> 2,6-二硝基甲苯
  • 用途二:有机合成中用作中间体。
  • Hazard Note:Irritant
  • 存储注意事项:氮气保护
  • MSDS 信息:4-Indolol(2380-94-1).msds
  • 敏感性:Air Sensitive
  • 下游产品:吲哚洛尔
  • 微溶于水，溶于丙酮。
  • TCI Shanghai:4-羟基吲哚 4-Hydroxyindole,>;99.0%(GC)(2380-94-1)
  • 4-羟基吲哚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 H0582 4-羟基吲哚 4-Hydroxyindole 5G 800元 2014/06/02 H0582 4-羟基吲哚 4-Hydroxyindole 25G 3000元 2010/06/21 204840010 4-羟基吲哚 4-Hydroxyindole 99% 1 GR 2003元

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indazoles 吲唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indoles 吲哚
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indolines 吲哚啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Indoles 吲哚
  5. C7 to C9 - Indoles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Indoles

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