H-DL-Trp(5-OH)-OH 5-羟基色氨酸
CAS 56-69-9 MFCD00005651
化学结构图
SMILES:
化学属性
| Mol. Formula | C11 H12 N2 O3 |
|---|---|
| Mol. Weight | 220.22 |
| Melting Point | ca 298° dec. |
| TSCA | Yes |
| Density | 1.484 |
| Solubility | Soluble in water (4 mg/ml at 25 °C), DMSO (44 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and methanol. |
别名和识别编码
| Chemical Name | H-DL-Trp(5-OH)-OH |
|---|---|
| Synonym | 2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)-PROPIONIC ACID 2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID 5-HYDROXY-DL-TRYPTOPHAN 5-HYDROXYTRYPTOPHAN 5-Htp 5-Hydroxy Tryptophan {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} |
| MDL Number | MFCD00005651 |
| CAS Number | 56-69-9 |
| Beilstein Registry Number | 88199 |
| EC Number | 200-284-8 |
| Merck Number | 4847 |
| Chemical Name Translation | 5-羟基色氨酸 |
| Reaxys-RN | 88199 |
| PubChem Substance ID | 87570731 |
| Wiswesser Line Notation | T56 BMJ D1YZVQ GQ |
| LabNetwork Molecule ID | LN00192906 |
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产品应用
- A tryptophan metabolite
相关文献及参考
- [2]. Gijsman HJ, et al. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol. 2002 Apr;22(2):183-9.
- [3]. Schruers K, et al. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Res. 2002 Dec 30;113(3):237-43.
- [1]. Gartside SE, et al. Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol. 1990 Apr 10;179(1-2):103-9.
- [1]. Gartside SE, et al. Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol. 1990 Apr 10;179(1-2):103-9.
- [2]. Gijsman HJ, et al. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol. 2002 Apr;22(2):183-9.
- [3]. Schruers K, et al. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder
安全信息
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE : 30 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) REFERENCE : ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 24(Suppl 3),1,1963
其他信息
- 5-Hydroxy Tryptophan (5-HTP) is a direct 5-hydroxytryptamine (5-HT) precursor that is used to assess central serotonergic function.
- 5-羟基色氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62015480 5-羟基-DL-色氨酸（+4°C） 1g 110元 2010/05/25 A12237 DL-5-羟基色氨酸, 99% DL-5-Hydroxytryptophan, 99% 5g 2380元 2010/05/25 A12237 DL-5-羟基色氨酸, 99% DL-5-Hydroxytryptophan, 99% 1g 524元
- MOL 文件:56-69-9.mol
- 用途一:生化研究。5-羟色氨酸是人体血清素的前体物质，可以帮助人体平衡这种荷尔蒙从而控制人体情绪、提高睡眠质量，并可以有效控制食欲，提高饱食中枢的敏感性，在减肥过程的饮食控制中，降低饥饿感，使减肥过程更轻松容易达成。
- Sigma Aldrich:56-69-9(sigmaaldrich)
- Alfa Aesar:DL-5-羟基色氨酸,99% DL-5-Hydroxytryptophan, 99%(56-69-9)
- MSDS 信息:DL-2-Amino-3-(5-hydroxyindolyl)propionic acid(56-69-9).msds
- 外观性质:白色结晶。固体时稳定，酸性溶液在-10℃时可稳定一年以上。中性或碱性溶液可增加其对氧的作用，惰性气体可防止其分解。溶解度(g/100ml)：水中5℃时为1，100℃时为5.5；50%沸乙醇中为2.5。熔点：291～294℃。在298～300℃时分解密度：1.484
