CAS 96-48-0 MFCD00005386-Gamma-Butyrolactone γ -丁内酯(易制毒，不能销售) TAO{mole}

Gamma-Butyrolactone γ -丁内酯(易制毒，不能销售)

CAS 96-48-0 MFCD00005386

化学结构图

SMILES: O=C1CCCO1

化学属性

Mol. Formula	C4H6O2
Mol. Weight	86
Density	1.129
Refractive index	1.4360 to 1.4380
Boiling Point	80-81
Melting Point	-45
Autoignition Point	851 °F
Vapor Density	3 (vs air)
Vapor Pressure	1.5 mmHg ( 20 °C)
Flash Point	101°C(lit.)
Solubility	MISCIBLE
Stability	对湿度敏感,对光线敏感
pH	-:A
Danger-Level	-
Redox	-

别名和识别编码

Chemical Name	Gamma-Butyrolactone
CAS Number	96-48-0
Synonym	γ-丁内酯 γ-羟基丁酸 1,2-Butanolide 1,4-BUTANOLIDE 1,4-Butanolide 1-Oxacyclopentan-2-one 2,3,4,5-tetrahydro-2-furanone 2-Oxotetrahydrofuran 2-oxolanone 4-BUTYROLACTONE 4-HYDROXYBUTYRIC ACID GAMMA-LACTONE 4-Hydro 4-Hydroxybutanoic acid, γ-lactone 4-Hydroxybutyric acid lactone 4-butanolyde 4-deoxytetronic acid 4-hydroxybutanoic acid lactone 4-hydroxybutyric acid lactone ?-Hydroxybutyric Acid Lactone BLO BUTYROLACTONE,GAMMA- Butyric acid, 4-hydroxy-, gamma-lactone Butyryl lactone Dihydro-2(3H)-furanone FEMA 3291 GAMA-BUTYROLACTONE GAMMA-BUTYROLACTONE NCI-C55878 NIH 10540 dihydro-2(3H)-furanone {} {} {} {}
EC Number	202-509-5
Beilstein Registry Number	105248
MDL Number	MFCD00005386
PubChem Substance ID	7302
Reaxys-RN	105248
Merck Number	1596
Alfabeta Name	DIHYDROFURANONEBUTYROLACTONE H23(())--
Chemical Name Translation	γ -丁内酯(易制毒，不能销售)
Wiswesser Line Notation	T5OVTJ
InChI	InChI=1S/C4H6O2/c5-4-2-1-3-6-4/h1-3H2

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产品应用

气相色谱固定液(最高使用温度30℃，溶剂为甲醇)，分离分析烃类及各种含氧化合物、永久性气体。
γ-丁内酯是一种溶解性强、无毒、使用管理安全方便的高沸点溶剂，在石油加工中用作丁二烯、芳烃、高级润滑脂的抽提剂；在化纤行业中用作丙烯腈纤维的纺丝溶剂，是羊毛、尼龙、丙烯腈等纤维的染色助剂。。此外，还可用作电池、电容器制作，彩卷成色等。
生化上是γ-羟丁酸（GHB）的前体。它靠抑制多巴胺能神经元的冲动流阻止多巴胺释放。用γ-丁内酯预处理，能检测到自动受体诱导的多巴胺的释放。

安全信息

GHS Symbol

WGK Germany1

Hazard Codes Xn

Hazard statements

H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
H318 Causes serious eye damage 严重伤害眼睛
H302 Harmful if swallowed 吞食有害

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSLU3500000

Precautionary statements

P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P304+P340
P304+P340+P312
P305+P351+P338
P305+P351+P338+P337+P313
P308+P311
P309+P311
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S39 Wear eye/face protection 戴眼睛/面孔保护装置；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R36 Irritating to eyes 刺激眼睛
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Warnings IRRITANT

Storage condition 密封、防潮、避光贮存 2-8°C 充氩保存

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 191 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - adrenal cortex tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-406,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 gm/kg/42W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   31,41,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   13,70,1965

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5100 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0534527

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1720 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.  Labor Hygiene and
   Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
   V.1-36, 1957-1992. For publisher information, see MTPEEI
   Volume(issue)/page/year: 31(1),49,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GAFCC* GAF Material Safety Data Sheet.  (

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 25 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,638,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 20 uL/disc
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,175,1981

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 2580 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   13,60,1989

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 4940 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   13,60,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 25 gm/kg
SEX/DURATION            : male 20 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   ARANDR Archives of Andrology.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1978- Volume(issue)/page/year:
   10,239,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 500 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   PHTOEH Pharmacology and Toxicology (Copenhagen).  (Munksgaard International
   Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  V.60-    1987-
   Volume(issue)/page/year: 62,57,1988

Restrict 易制毒

其他信息

类别:易燃物质
方法二:1.顺酐加氢法该法是70年代发展的先进工艺，用一段加氢反应，能以任意比例生产四氢呋喃和γ-丁内酯，通常的比例是四氯呋喃：γ-丁内酯=3-4：1。生产企业较多，但规模小，平均300t/a。该法产能占国内总产能的30%。2.1,4-丁二醇脱氢法反应器为列管式，装填片状的铜催化剂（以氧化锌为载体）。反应温度控制在230-240℃。反应产物粗γ-丁内酯经减压蒸馏而得成品，收率77%以上。
食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称允许使用该种添加剂的食品中文名称添加剂功能最大允许使用量（g/kg）最大允许残留量（g/kg） γ-丁内酯食品食品用香料用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
海关编码:29322980
用途五:气相色谱固定液(最高使用温度30℃，溶剂为甲醇)，分离分析烃类及各种含氧化合物、永久性气体。重要的有机合成原料和优良溶剂。该产品可用于制造a-吡咯烷酮、N-甲基吡咯烷酮、聚乙烯吡咯烷酮，也是理想的抗氧剂、增塑剂、萃取剂、吸收剂、分散剂、固色剂、凝固剂；在医药行业可用作麻醉剂及镇静剂，可合成环丙沙星和干扰素等。是维生素、环丙胺等的中间体；在农林业方面也有广泛的用途，是生产植物生长剂、杀虫剂等的中间体。此外，还可用作电池、电容器制作，彩卷成色等。
毒性分级:中毒
用途四:γ-丁内酯是一种溶解性强、无毒、使用管理安全方便的高沸点溶剂，在石油加工中用作丁二烯、芳烃、高级润滑脂的抽提剂；在化纤行业中用作丙烯腈纤维的纺丝溶剂，是羊毛、尼龙、丙烯腈等纤维的染色助剂。在有机合成中，GBL也有广泛的用途，它是合成α-吡咯烷酮、N-甲基吡咯烷酮、乙烯基吡咯烷酮、乙酰基-γ-丁内酯、环丙胺等的原料，是
Acros Organics:gamma-丁内酯 gamma-Butyrolactone, 99+%(96-48-0)
图谱信息:gamma-丁内酯(96-48-0)红外图谱(IR1) gamma-丁内酯(96-48-0)核磁图
下游产品:四氢呋喃 --> N-甲基吡咯烷酮 --> 3-(2,2-二氯乙烯基)-2,2-二甲基环丙基羧酸甲基酯 --> 山梨酸 --> 环丙胺 --> 戊二酸 --> 二氯
急性毒性:口服-大鼠 LD50: 1540 毫克/公斤; 口服-小鼠 LD50: 1720 毫克/公斤
gamma-丁内酯价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30032727 1，4-丁内酯;γ-丁内酯;4-羟基丁酸内酯 250ml 23元 2011/08/23 40006160 1，
下游产品:四氢呋喃 --> N-甲基吡咯烷酮 --> 3-(2,2-二氯乙烯基)-2,2-二甲基环丙基羧酸甲基酯 --> 山梨酸 --> 环丙胺 --> 戊二酸 --> 二氯菊酸乙酯 --> 环丙甲酸 --> 苯丁酸 --> 4-氯苯丁酮 --> 5-羟基-2-戊酮 --> 1-四氢萘酮 --> 2-吡咯烷酮 --> 3,3,4,4-二苯基砜四羧酸二酸酐 --> alpa-乙酰基-gama-丁酯 --> 泛酸钙 --> 3-吲哚丁酸 --> 2,6-二氟苯腈 --> ALPHA,ALPHA-二甲基-GAMMA-丁内酯 --> 4
蒸气压:1.5 mm Hg ( 20 °C)
和水完全可以互溶，可溶于乙醇、乙醚、苯和丙酮，能溶解许多有机和无机化合物。在热碱溶液中分解。是一种沸点高、溶解性强、电性能及稳定性好的溶剂。使用安全、简便。有芳香气味。有吸湿性。能随水蒸气挥发。
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用途四:γ-丁内酯是一种溶解性强、无毒、使用管理安全方便的高沸点溶剂，在石油加工中用作丁二烯、芳烃、高级润滑脂的抽提剂；在化纤行业中用作丙烯腈纤维的纺丝溶剂，是羊毛、尼龙、丙烯腈等纤维的染色助剂。在有机合成中，GBL也有广泛的用途，它是合成α-吡咯烷酮、N-甲基吡咯烷酮、乙烯基吡咯烷酮、乙酰基-γ-丁内酯、环丙胺等的原料，是合成杀虫剂、除草剂、药物脑复康、环丙氟哌酸、维生素B1，叶绿素等的中间体。还用于合成氯苯氧基丁酸类除莠剂，植物生长调节剂。
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