Dicyclohexano-18-Crown-6 二环己烷并-18-冠醚-6

CAS 16069-36-6 MFCD00005099

化学结构图

16069-36-6
SMILES: C1COC2CCCCC2OCCOCCOC2CCCCC2OCCO1

化学属性

Mol. FormulaC20H36O6
Mol. Weight373
Melting Point47-50 °C
Flash Point>110°(230°F)
TSCAYes
Boiling Point344°C(lit.)
Solubility略溶于水

别名和识别编码

Chemical NameDicyclohexano-18-Crown-6
CAS Number16069-36-6
Alfabeta NameICOSAHYDRODIBENZOHEXAOXACYCLOOCTADECINE BK147101316[[]]-,,,,,,
MDL NumberMFCD00005099
Synonym Perhydrodibenzo-18-crown-6; 2,3,11,12-Dicyclohexano-1,4,7,10,13,16- hexaoxacyclooctadecane D2-06 二环己烷并-18-冠醚-6 全氢-二苯并-18-冠-6 2,5,8,15,18,21-Hexaoxatricyclo(20.4.0.0(sup 9,14))hexacosane 2,3,11,12-双环己基-1,4,7,10,13,16-六氧环十八烷 Dicyclohexano-18-crown-6 二环己基并-18-冠醚-6 2,5,8,15,18,21-六氧杂三环[20.4.0.09.14]二十六烷 Dicyclohexyl-18-crown-6 2,3,11,12-双环己基-1,4,7,10,13,16-六氧环十八烷 2,5,8,15,18,21-六氧杂三环[20.4.0.09.14]二十六烷 二环己基并-18-冠醚-6 全氢-二苯并-18-冠-6
PubChem Substance ID87568145
EC Number240-216-4
Beilstein Registry Number1130529
Merck Number14,2602
Reaxys-RN1130529
Chemical Name Translation二环己烷并-18-冠醚-6
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分类

  • {SNA} Chelation/Complexation Compounds, Chemical Reagents, Chemical Synthesis, Crown Ethers, Development Quantities for Research, Synthetic Reagents
  • {SNA} Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Synthetic Reagents
  • {SNA} Chemical Reagents, Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Development Quantities for Research, Synthetic Reagents

相关文献及参考

  • Crown ether (see Appendix 2). Increases the rate of acetolysis of benzyl chloride in acetonitrile by a factor of >;400: Synthesis, 117 (1981).
  • In combination with potassium permanganate, effects the stereoselective cis-hydroxylation of a double bond from the less-hindered side: Chem. Lett., 173 (1983).

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany1
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H331 Toxic if inhaled 吸入中毒
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECSHP5385000
Precautionary statements
  • P301+P310
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P301+P310+P330
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P332+P313
  • P405 Store locked up. 上锁保管。
  • P305+P351+P338+P337+P313
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P337+P313
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P304+P340+P312
  • P302+P352+P312
  • P403+P233
Signal word Danger
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S38 In case of insufficient ventilation wear suitable respiratory equipment 通风不良时,佩带适当的呼吸器;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
Packing GroupIII
UN Number 2811 UN2811
Risk Statements
  • R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
  • R36 Irritating to eyes 刺激眼睛
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R25 Toxic if swallowed 吞咽有毒
Storage condition Hygroscopic
Hazard Codes T
Hazard Class6.1
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0571202

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 192 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle contraction or spasticity
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 52(11),72,1987

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 53 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 8,451,1

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 105 mg/kg
SEX/DURATION            : female 1-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 52(11),72,1987

系列性分类


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