CAS 92-84-2 MFCD00005015-Phenothiazine 吩噻嗪 TAO{mole}

Phenothiazine 吩噻嗪

CAS 92-84-2 MFCD00005015

化学结构图

SMILES: c1ccc2c(c1)Nc1ccccc1S2

化学属性

Mol. Formula	C12H9NS
Mol. Weight	199.27
Density	1.362
TSCA	Yes
Boiling Point	371.003 °C at 760 mmHg
Melting Point	184 °C
Refractive index	1.6353
Solubility	Soluble in water (0.13 mg/ml at 23 °C), ethanol, acetone (very), and ether (freely). Insoluble in chloroform.
Stability	对光线、空气敏感
Flash Point	202°C

别名和识别编码

Chemical Name	Phenothiazine
CAS Number	92-84-2
Synonym	Phenothiazine {LY} Phenothiazine {} {LY} Phenothiazine {} {} {LY} Phenothiazine {} {} {} {LY} Phenothiazine {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Phenothiazine {} {} {} {} {} {} {} {} {} {} {}
EC Number	202-196-5
Beilstein Registry Number	143237
MDL Number	MFCD00005015
Merck Number	7252
PubChem Substance ID	87574363
Reaxys-RN	143237
Chemical Name Translation	吩噻嗪
Wiswesser Line Notation	T C666 BM ISJ
LabNetwork Molecule ID	LN00195462
Canonical SMILES	C12=CC=CC=C1NC3=C(C=CC=C3)S2

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分类

{Chemicalbook} 饲料添加剂:
{uni_hamburg} no charge; sulfur heterocycle; nitrogen heterocycle; carbocycle; aromatic; large ring; fus
{SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, Others, P,
{SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, Others, P, PER - POLA, Pesticides, Bactericides, Fungicides and Disinfectants, Standards for Personal Care and Cosmetic Products, neats, prohibited substances (EU-REGULATION No 1223/2009)
Heterocycles
Pharmaceuticals
{S
{SNA} Building Blocks,
{Chemicalbook} 饲料添加剂: 驱虫保健剂

产品应用

A rigid, tricyclic thiazine useful as an electron donor.

安全信息

Signal word

GHS Symbol

WGK Germany3

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S24 Avoid contact with skin 避免皮肤接触；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S37 Wear suitable gloves 戴适当手套；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S29 Do not empty into drains 不要排入下水道；

Risk Statements

R52/53
R48/22
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R22 Harmful if swallowed 吞咽有害

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P403+P233
P501 Dispose of contents/container to..… 处理内容物/容器.....
P273 Avoid release to the environment. 避免释放到环境中。
P307+P311
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P302+P350
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P302+P352+P333+P313+P362+P364
P337+P313

RTECSSN5075000

Storage condition 2-8°C {LY} 2-8°C Light Sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

Hazard statements

H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H302 Harmful if swallowed 吞食有害
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H303 May be harmfully swallowed 吞食可能有害

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes Xn Xi;N Xi Xi,N

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Bird - wild bird species
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JACSAT Journal of the American Chemical Society.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1879-  Volume(issue)/page/year: 66,888,1944

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cattle
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,1104,1986

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 425 mg/kg/5D
TOXIC EFFECTS :
   Behavioral - headache
   Liver - jaundice, other or unclassified
   Blood - normocytic anemia
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 242,86,1942

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
REFERENCE :
   DNEUD5 Developments in Neuroscience (Amsterdam).  (Elsevier Science Pub.
   Co., Inc., 52 Vanderbilt Ave., New York, NY 10017)  V.1-    1977-
   Volu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1250 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   AJANA2 American Journal of Anatomy.  (Alan R. Liss, Inc., 41 E. 11th St.,
   New York, NY 10003) V.1-192, 1901-91.  Volume(issue)/page/year: 110,29,1962

其他信息

参考质量标准:参考指标含量(干基)/% ≥97.0 熔点/℃ 183～186 灼烧残渣/% ≤0.1 挥发物/% ≤0.1
储运特性:库房通风低温干燥; 与氧化剂分开储运
用途一:主要用作丙烯酸及丙烯酸酯类、甲基丙烯酸及酯类单体的高效阻聚剂
理化性质与吩噻嗪的作用:吩噻嗪是由硫、氮原子连接两个苯环(吩噻嗪母核)组成的一种有机芳香化合物，从乙醇或苯中重结晶者为正交晶系黄色或灰绿色棱柱状晶体，从甲苯或丁醇中析出者为黄色叶片状结晶，随水蒸气一起挥发。相对分子质量199.28。熔点186～189℃。沸点371℃、290℃(5.333×103Pa)、130℃(0.133× 103Pa)升华。不溶于水、石油醚和氯仿，微溶于乙醇和矿物油，溶于乙醚和丙酮，易溶于苯和热醋酸，25℃的溶解度(g/100g)：丙酮25.40、乙醇 3.40、苯32.0。在日照下及空气中，颜色变深，贮存时可加0.3%的甲胺予以保护。有杂质时颜色也易变深。遇酸及酸蒸气时分解，并产生有毒的氧化氮和氧化硫气体。吩噻嗪具有升华性，有微弱的异臭，对皮肤有刺激性，可引起斑疹，也能经皮吸收，引起内脏障碍。大鼠经口LD50 5000mg/kg。工作场所最高允许浓度5mg/m3。实验室通过将二苯胺与硫同时加热，直至无硫化氢气体放出即得。吩噻嗪为制造次甲基蓝染料的中间体，也可用以制造一类重要的安定药及抗组织胺药如氯丙嗪、奋乃静、异丙嗪及甲硫哒嗪等。另外吩噻嗪还可用作醋酸乙烯的阻聚剂、橡胶用防老剂的原料、合成染料、药物、果树杀虫剂和牲畜驱虫剂等。以上信息由Chemicalbook的晓楠编辑整理。
吩
方法二:由二苯胺经硫化而得。原料消耗定额：二苯胺1660kg/t、硫磺660kg/t、碘片17kg/t。
方法一:以二苯胺为原料，再碘的催化下经硫化而得。将二苯胺、碘片和硫磺混合，加热至200℃反应2h，然后用过热蒸汽直接加热至220-250℃。反应物料与水分离后用乙醇和乌洛托品（质量比1.5:1)混合液洗涤，再经干燥、粉碎得产品。
职业标准:TLV-TWA 5 毫克
灭火剂:干粉、泡沫、砂土
微有气味。具有微弱的异臭，长时间放于空气中易氧化而颜色变深，对皮肤有刺激性。在130℃(133.32Pa)时升华。在日光影响下极易氧化。易溶于苯，溶于乙醚和热乙酸，微溶于乙醇和矿物油，能很好地溶于丙酮和苯，几乎不溶于石油醚、氯仿和水。水中溶解度:2mg/L (25°C)。
图谱信息:吩噻嗪(92-84-2)核磁图( 1 HNMR) 吩噻嗪(92-84-2)质谱(MS) 吩噻嗪(92-84-2)核磁图( 13 CNMR) 吩噻嗪(92-84-2)红外图谱(IR2) 吩噻嗪(92-84-2)红外图谱(IR1)
用
毒性分级:中毒
用途二:吩噻嗪是较广泛使用的驱虫药，对牛、马、羊的捻转胃虫、结节虫、仰口线虫、夏氏线虫等均由良好效果。
上游原料:苯 --> 硫磺 --> 碘 --> 乌洛托品 --> 二苯胺
外观性质:黄色结晶粉末，颗粒或片状，易氧化变色。
Alfa Aesar:吩噻嗪,98+% Phenothiazine, 98+%(92-84-2)
敏感性:Light Sensitive
MOL 文件:92-84-2.mol
用途四:主要用作丙烯酸酯及甲基丙烯酸酯生产的阻聚剂。也用于药物、染料的合成，以及作为合成材料用助剂等。
海关编码:29343090
类别:农药
F:8-23
可燃性危险特性:可燃；燃烧产生有毒硫氧化物和氮氧化物气体
用途三:吩噻嗪是药物、染料等精细化学品的中间体，其本身是合成材料用助剂（生产维尼纶的阻聚剂）、果树杀虫剂
下游产品:丙烯酰胺 --> 乙吗噻嗪 --> 盐酸异丙嗪
Sigma Aldrich:92-84-2(sigmaaldrich)