Aristolochic acid 马兜铃酸A
CAS 313-67-7 MFCD00004996
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} AN-AZ, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, Carcinogens, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Lipids in Cell Signaling, P to Q, Phospholipase A2, Phospholipase Inhibitors, Phospholipid Metabolism, 生物活性小分子, 癌症研究, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
- {SNA} AN-AZ,
- {SNA} AN-AZ, Bioactive Small Molecule Alphabetical Index, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Lipids in Cell Signaling, P to Q, Phospholipase A2, Phospholipase Inhibitors, Phospholipid Metabolism,
产品应用
- 马兜铃酸I是一种强效的磷脂酶A2抑制剂。马兜铃酸I诱导大鼠肾脏肿瘤的形成和人肾近端肾小管上皮细胞凋亡。
相关文献及参考
- Kupchan, D., et al.: J. Med. Pharm. Chem., 5, 657 (1962),
- Merck: 14,786
- Wei, J., et al., A new reversed-phase/strong anion-exchange mixed-mode stationary phase based on polar-copolymerized approach and its application in the enrichment of aristolochic acids J. Chromatogr. A. 1246 , 129-36, (2012)
- Coutts, et al.: J. Pharm. Pharmacol., 11, 607 (1959),
- Mix, D.B., et al.: J. Nat. Prod., 45, 657 (1982),
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- H351 Suspected of causing cancer 怀疑致癌
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P301+P310
- P301+P316
- P302+P350
- P304+P340
- P305+P351+P338
- P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
- P330 Rinse mouth. 漱口
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S35 This material and its container must be disposed of in a safe way 该物料及其容器必须以安全方式处置;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
- S7 Keep container tightly closed 保存在严格密闭容器中;
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
- R25 Toxic if swallowed 吞咽有毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R45 May cause cancer 可能致癌
- R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 105 mg/kg/3W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Gastrointestinal - tumors REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 61,504,1988
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 55900 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 59,32
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory depression Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation,
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 3 mg/kg/2D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 42,35,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 38400 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 59,328,1987
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 50 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 206,447,1988
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 200 ug/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 50 ug/plate REFERENCE : CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 55,7,1990
TYPE OF TEST : Sex chromosome loss and nondisjunction ROUTE OF EXPOSURE : Oral TEST SYSTEM : Insect - Drosophila melanogaster DOSE/DURATION : 50 umol/L REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 56,158,1985
TYPE OF TEST : DNA adduct ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - rat DOSE/DURATION : 40 mg/kg/2W (Intermittent) REFERENCE : CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,1187,1994
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 5 mg/L REFERENCE : HUGEDQ Human Genetics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.31- 1976- Volume(issue)/page/year: 64
其他信息
- MOL 文件:313-67-7.mol
- Acros Organics:马兜铃酸 Aristolochic acid, mixture of I and II, 96%(313-67-7)
- 类别:有毒物质
- 毒性分级:高毒
- Sigma Aldrich:313-67-7(sigmaaldrich)
- color:yellow
- MSDS 信息:8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid(313-67-7).msds
- 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物烟雾
- 储运特性:库房通风低温干燥; 与食品原料分开存放
- 马兜铃酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 226095000 马兜铃酸 Aristolochic acid 96%, mixture of I and II 500 MG 3557元 2010/06/21 226091000 马兜铃酸 Aristolochic acid 96%, mixture of I and II 100 MG 1042元
- 灭火剂:水, 二氧化碳, 泡沫, 沙土
- 急性毒性:口服-大鼠 LD50: 184 毫克/公斤; 口服-小鼠 LD50: 55.9 毫克/公斤