2,3-Dimercapto-1-propanol 2,3-二巯基-1-丙醇

CAS 59-52-9 MFCD00004864

化学结构图

59-52-9
SMILES: OCC(S)CS

化学属性

Mol. FormulaC3H8OS2
Mol. Weight124
Refractive index1.5690 to 1.5750
Boiling Point120
Density1.239
Flash Point>110°(230°F)
TSCAYes
Solubility溶于油类、醇、醚。
Stability对空气敏感

别名和识别编码

Chemical Name2,3-Dimercapto-1-propanol
Synonym Dimercaprol, BAL, DMP,
CAS Number59-52-9
PubChem Substance ID3080
EC Number200-433-7
Beilstein Registry Number1732058
MDL NumberMFCD00004864
Reaxys-RN1732058
Merck Number3209
Chemical Name Translation2,3-二巯基-1-丙醇
Wiswesser Line NotationSH1YSH1Q
LabNetwork Molecule IDLN00192920
InChIInChI=1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Reagents, Analytical Standards, Analytical/Chromatography,
  • {SNA} Building Blocks, Chemical Synthesis, Organic Building Blocks, Sulfur Compounds, Thiols/Mercaptans
  • Alphabetic, Analytical Reagents, Analytical Standards, Analytical/Chromatography, Complexometric Titration Reagents (EDTA Titration), D, DID - DIN, Masking Agents, Spe
  • {SNA} Complexometric Titration Reagents (EDTA Titration), Masking Agents, Spectroscopy, Titration, UV/Vis Reagents, UV/Visible (UV/VIS) Spectroscopy, 分析/色谱, 分析试剂

产品应用

  • 本品为解毒药,主要用于含砷或含汞毒物的解毒,也可用于某些重金属(如铋、锑、镉等)的中毒。2,3-二巯基丙醇与路易斯气反应,生成稳定、不溶而无毒的砷化合物。因此被称为英国抗路易斯气剂。与二巯基丙醇解毒作用相似的品种是二巯基丁二酸钠(C4H4Na2O4S2)。也用作光度法测定铜。

相关文献及参考

  • 1. J.F. Danielli et al. Biochem. J. 41 , 325, (1947) 摘要
  • 2. F.W. Oehme Toxicity of Heavy Metals in the Environment New York , (1979)
  • 3. J.C. Majumdar, B.C. Haldar Radiochem. Radioanal. Lett. 48 , 247, (1981)
  • 4. E. Casassas Chimie analyt. 47 , 419, (1965)
  • Merck 14 ,3209
  • Beil. 1 ,IV,2770
  • Aldrich MSDS 1 , 726:D / Corp MSDS 1 (1), 1303:D / FT-IR 1 (1), 262:D / FT-IR 2 (1), 417:C / FT-NMR 1 (1), 423:C / IR-Spectra (3), 155:B / IR-Spectra (2), 138:H / NMR-Reference 2 (1), 230:A / RegBook 1 (1), 283:B / Sax 6 , 343 / Sigma FT-IR 1 (2), 482:D / Structure Index 1 , 38:D:8 / Vapor Phase 3 , 345:D
  • Short: III/38B Title: Refractive Indices of Organic Liquids Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: III/38B Year: 1996 Keyword: organic compounds; refractive index; liquids ISBN: 3-540-60596-7 ISBN: 978-3-540-60596-6 Internet Resource: DOI:10.1007/b85533 RefComment: VII, 4210 pages, Hardcover Abstract: Volume III/38 Optical Constants provides critically evaluated data on refractive indices of inorganic and organic liquids and their wavelength dependence (dispension). Part A contains the inorganic, organometallic, and organononmetallic liquids, and the binary liquid mixtures (about 900 pure substances and their mixtures). Part B contains data of more than 7600 organic liquids.
  • Short: IV/18B Title: Viscosity of Pure Organic Liquids and Binary Liquid Mixtures: Pure Organic Liquids Author: Wohlfarth, Ch.; Wohlfarth, B. Editor: Lechner, M.D. Source: Landolt-Börnstein, New Series Volume: IV/18B Year: 2001 Keyword: organic compounds; viscosity; liquids; mixtures Internet Resource: DOI:10.1007/b68240 RefComment: VII, 409 pages.
  • Short: IV/20A Title: Vapor Pressure and Antoine Coeffic

安全信息

GHS Symbol
WGK Germany3
Hazard Codes 6.1
Hazard statements
  • H301 Toxic if swallowed 吞食有毒
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSUB2625000
Precautionary statements
  • P362+P364
  • P301+P316
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P405 Store locked up. 上锁保管。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P403+P233
  • P337+P317
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P319
  • P305+P351+P338
  • P332+P317
  • P330 Rinse mouth. 漱口
  • P264+P265
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
Signal word Danger
UN Number 2810
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Storage condition 密封充氩保存;储存温度2-8°C 2-8°C Air Sensitive
Packing GroupIII
Hazard Class6.1
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BIJOAK Biochemical Journal.  (Biochemical Soc. Book Depot, POB 32, Commerce
   Way, Colchester, Essex CO2 8HP, UK)  V.1-    1906- Volume(issue)/page/year:
   41,325,1947

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human
DOSE/DURATION           : 3 mg/kg
TOXIC EFFECTS :
   Blood - hemorrhage
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-

{ha

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 100 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ANREAK Anatomical Record.  (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
   10003)  V.1-    1906/08-  Volume(issue)/page/year: 135,261,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 200 mg/kg
SEX/DURATION            : female 12-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   ANREAK Anatomical Record.  (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
   10003)  V.1-    1906/08-  Volume(issue)/page/year: 135,261,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 100 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   ANREAK Anatomical Record.  (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
   10003)  V.1-    1906/08-  Volume(issue)/page/year: 135,261,1959

其他信息

  • TCI Shanghai:2,3-二巯基-1-丙醇 2,3-Dimercapto-1-propanol,>;95.0%(GC)(T)(59-52-9)
  • F:8-9-13-23
  • MOL 文件:59-52-9.mol
  • Alfa Aesar:2,3-二巯基丙醇,97% 2,3-Dimercaptopropanol, 97%(59-52-9)
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 类别:有毒物品
  • MSDS 信息:二巯基丙醇(59-52-9).msds
  • Acros Organics:2,3-二巯基-1-丙醇 2,3-Dimercapto-1-propanol, 97.0-100.5%(59-52-9)
  • 用途二:本品为解毒药,主要用于含砷或含汞毒物的解毒,也可用于某些重金属(如铋、锑、镉等)的中毒。2,3-二巯基丙醇与路易斯气反应,生成稳定、不溶而无毒的砷化合物。因此被称为英国抗路易斯气剂。与二巯基丙醇解毒作用相似的品种是二巯基丁二酸钠(C4H4Na2O4S2)。也用作光度法测定铜。
  • 海关编码:29309070
  • 急性毒性:腹腔-大鼠 LD50: 105 毫克/公斤; 口服-小鼠 LD50: 217 毫克/公斤
  • 用途一:本品为解毒药,主要用于含砷或含汞毒物的解毒,也可用于某些重金属(如铋、锑、镉等)的中毒。2,3-二巯基丙醇与路易斯气反应,生成稳定、不溶而无毒的砷化合物。因此被称为英国抗路易斯气剂。与二巯基丙醇解毒作用相似的品种是二巯基丁二酸钠(C4H4Na2O4S2)。这是我国创制的新解毒药,解毒效力比二巯基丙醇强,且毒性较小。二巯基丙醇对鼠皮下注射LD50为86.7毫克/公斤。
  • 外观性质:粘稠的油状液体,具有刺激性亚臭味。
  • 可燃性危险特性:可燃; 燃烧产生有毒硫氧化物烟雾;患者使用副作用;出血,皮炎,皮肤泛红肿胀
  • 方法一:由丙烯醇经加成、巯化而得。
  • 储运特性:通风低温干燥; 与库房食品分开存放
  • 毒性分级:高毒
  • 敏感性:Air Sensitive
  • 上游原料:丙烯醇
  • 二巯丙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30065780 2,3-二巯基丙醇(+4℃) 5g 895元 2011/04/16 D0621 2,3-二巯基-1-丙醇 2,3-Dimercapto-1-propanol 25G 3650元 2011/04/16 D0621 2,3-二巯基-1-丙醇 2,3-Dimercapto-1-propanol 1G 356元
  • Sigma Aldrich:59-52-9(sigmaaldrich)
  • 有类似蒜的特臭。能溶于水,极易溶于甲醇、乙醇和苯甲酸及植物油。水溶液不稳定。1克本品可溶于13毫升水并同时分解,生成二硫化物。有类似的葱蒜样的气味。在空气中易氧化,在乙醇中密封可长期保存。

系列性分类


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