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分类

• {SNA} A - D, A-B, A-D, Alphabetical Listings, Certified Food Grade Products, Certified Natural Products, Flavors and Fragrances, Halal Certified Products, Kosher Certified Products
• {Chemicalbook} 食品添加剂: 食用香料（增香剂）: 天然等同香料和人造香料
• {SA} Alcohols, Building Blocks, C7 to C8, Chemical Sy
• {SNA} A - D, A-B, A-D, Alphabetical Listings, Certified Food Grade Products, Flavors and Fragrances, Halal Certified Products, Kosher Certified Products
• {SNA} A-B, A-D, Alphabetical Listings, Certified Food Grade Products, Flavors and Fragrances,
• {SNA} 2009/48/EC (Directive o

产品应用

• 对碳水化合物的反构体OH-基团提供临时性保护作用。

相关文献及参考

• Carboxyl protection agent giving the 4-methoxybenzyl (PMB; 4-methoxyphenylmethyl; MPM) ester, e.g. by reaction with the 4-nitrophenyl ester. The group is stable to 0.5N HCl in MeOH which readily cleaves Boc groups, but can be removed by TFA, leaving Cbz-groups unaffected: Austr. J. Chem., 21, 2543 (1968). For cleavage using AcOH at 90o, see: Synth. Commun., 24, 1151 (1994). For cleavage with Cerium(III)­ chloride heptahydrate, A12947, in the presence of NaI, see: J. Org. Chem., 64, 5696 (1999). See Appendix 6.
• Has also been used, in the presence of TFA, to protect thiols: Tetrahedron Lett., 35, 1631 (1994). Cleavage is by
• Has also been used, in the presence of TFA, to protect thiols: Tetrahedron Lett., 35, 1631 (1994). Cleavage is by refluxing with TFA: Bull. Chem. Soc. Jpn., 37, 433 (1964); Bioorg. Chem. Med. Lett., 3, 739 (1993), or Hg(II) salts: Chem. Pharm. Bull., 26, 1576 (1978); J. Med. Chem., 31, 2199 (1988); J. Org. Chem., 52, 4420 (1987).
• Merck:14,604
• Merck:14,604 Beilstein:6,897

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 12,825,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 93,26,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 93,26,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1600 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 93,26,1948

其他信息

• 用途四:GB 2760—1996规定为
• 使用限量:FEMA(mg/kg)：软饮料7.4；冷饮8.0；糖果11；焙烤食品12；布丁类1.9。 适度为限(FDA§172．515，2000)。
• FEMA:2099
• 不溶于水，溶于1体积50%醇，溶于醚。
• 方法二:由大茴香醛还原制得。将大茴香和甲醛、氢氧化钠在乙醇中发生康尼查罗（Cannizzaro）反应，生成对甲氧基苯甲醇。蒸馏回收乙醇后，反应所得油层用苯萃取，加乙酸酸化，再用碳酸氢钠中和至弱碱性，水洗至中性后，蒸馏回收苯，剩余物进行减压蒸馏，得对甲氧基苯甲醇。
• 上游原料:对甲氧基苯甲醛 --> 氯化亚铁 --> 铂金
• 用途三:主要用于带清香的花香型香精中，如山楂花、茉莉、金合欢、含羞花、刺槐、紫丁香、铃兰、紫罗兰、玉兰、葵花、水仙等
• 用途一:用作医药中间体
• 毒性:ADI 1mg/kg(CE)。 LD 50 1200mg/kg(大鼠，经口)。
• 下游产品:乙酸大茴香酯
• 4-甲氧基苄醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0107 4-甲氧基苄醇 4-Methoxybenzyl Alcohol 500G 974元 2014/06/02 M0107 4-甲氧基苄醇 4-Methoxybenzyl Alcohol 25G 152元 2010/06/21 159735000 4-甲氧基苄醇 4-Methoxybenzyl alcohol 98% 500 GR 1155元
• 参考质量标准:FCC，1996 含量 ≥97.0% 折射率(n D 25 ) l.542～1.547 凝固点 ＞23.5℃ 相对密度(d 25 25 ) 1.110～1.115 酸值(OT-4) ≤l.0 醛类(以茴香醛C8H8O2计) ≤1.0% 醇中溶解度 1ml溶于1mL 50%乙醇，稀释至10ml不变
• 图谱信息:4-甲氧基苄醇(105-13-5)质谱(MS) 4-甲氧基苄醇(105-13-5)核磁图( 1 HNMR) 4-甲氧基苄醇(105-13-5)红外图谱(IR1) 4-甲氧基苄醇(105-13-5)Raman光谱 4-甲氧基苄醇(105-13-5)红外图谱(IR2) 4-甲氧基苄醇(105-13-5)红外图谱(IR3) 4-甲氧基苄醇(105-13-5)核磁图( 13 CNMR)
• 八角茴香油:八角茴香油又称八角油，在20摄氏度以上时为无色透明或淡黄色液体，温度下降时会有片状结晶析出，有茴香脑的香气和甜味。微溶于水，易溶于乙醇、乙醚和氯仿中。八角系木兰科，八角属。其果实是聚合果，呈八角形，故俗称为八角茴香，也称大料等。八角茴香油是一种成分复杂的芳香油，是挥发油，略具粘性。色泽以灰白色为好，黄色则稍次，味甘美而刺舌，具有强烈的八角香气。在10－15℃的温度下，搅拌之则凝结。其主要成分是反式大茴香脑，含量高达80%以上。还含有α－蒎烯、柠檬烯、芳樟醇、黄樟素、大茴香醛、茴香酮、4－萜品醇、草蒿脑、茴香醛等成分。八角油是一种技术性较强，没有化学仪器不容易鉴别的芳香油。目前产区还是通过收购员用肉眼看、鼻子闻来鉴定八角油的品质。八角油在香料工业中主要用于提取大茴香脑，并再合成大茴香醛、大茴香醇(对甲氧基苯甲醇、4-甲氧基苄醇)。些单体香料均广泛用于牙膏、食品、香皂和化妆品香精。其果实是我国人民常用的食品调味香料。同时八角油在制药工业中是合成阴性激素已烷雌酚的主要原料。由于八角油比水轻，悬浮于水面上，油水分离后的水含有八角油返回蒸馏锅进行复馏以提高出油率。
• 含量分析:按总醇量测定法(OT-5)进行。其中皂化用的乙酰化醇量取1.5g。计算中的当量因子(e)取69.09。或按GT-10-4中气相色谱法非极性柱方法测定。
• Sigma Aldrich:105-13-5(sigmaaldrich)
• Hazard Note:Irritant
• 海关编码:29094990
• MOL 文件:105-13-5.mol
• 用途四:GB 2760—1996规定为允许使用的食用香料。主要供配制香草、巧克力