(S)-2-Amino-3-(3,4-Dihydroxyphenyl)-2-Methylpropanoic Acid (S)-2-氨基-3-(3,4-二羟基苯基)-2-甲基丙酸
CAS 555-30-6 MFCD00004186
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相关文献及参考
- [2]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350.
- [1]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56.
- [1]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56.
- [2]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350.
安全信息
- H303 May be harmfully swallowed 吞食可能有害
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 1071 mg/kg/22W-I TOXIC EFFECTS : Skin and Appendages - dermatitis, allergic (after systemic exposure) REFERENCE : CUTIBC CUTIS; Cutaneous Medicine for the Practitioner. (Technical Pub., 875 Third Ave., New York, NY NY 10022) 1965- Volume(issue)/page/year: 38,187,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,348,1972
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 1830 mg/kg/17W-I TOXIC EFFECTS : Peripheral Nerve and Sensation - fasciculations Behavioral - hallucinations, distorted perceptions Behavioral - tremor REFERENCE : SAMJAF South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932- Volume(issue)/page/year: 65,194,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 44 gm/kg/3Y-I TOXIC EFFECTS : Gastrointestinal - necrotic changes REFERENCE : AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 105,1037,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSER
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 12500 ug/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 259,127,1991
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 37 mg/L REFERENCE : GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981
TYPE OF TEST : Dominant lethal test ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 960 mg/kg REFERENCE : CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 41,151,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 7500 mg/kg SEX/DURATION : female 6-20 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - parturition Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB86-245321
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 13 gm/kg SEX/DURATION : male 65 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 41,305,1986
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 960 mg/kg SEX/DURATION : male 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969- Volume(issue)/page/year: 41,151,1984
TYPE OF TEST : TDLo - Lowest publis
GHS Symbol
其他信息
- 用途一:左旋甲基多巴是一种B-受体阻滞型心血管药物,对中等程序的原发性和肾性高血压有良好疗效。
- 甲基多巴价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1817 3-(3,4-二羟基苯基)-2-甲基-L-丙氨酸 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine 5G 728元 2014/06/02 D1817 3-(3,4-二羟基苯基)-2-甲基-L-丙氨酸 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine 25G 2020元
- MSDS 信息:2-Amino-3-(3,4-dihydroxyphenyl)-2-methyl-propanoic acid(555-30-6).msds
- TCI Shanghai:3-(3,4-二羟基苯基)-2-甲基-L-丙氨酸 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine,>;98.0%(T)(555-30-6)
- F:10-23
- 方法一:将香兰醛用硫酸二甲酯甲基化为藜芦醛,再与硝基乙烷缩合得到1-(2-硝基丙烯基)-3',4'-二甲氧基苯,用铁粉还原并经水解后生成3',4'-二甲氧基苯丙酮(见14945),然后经环合、开环、水解反应得到DL-甲基多巴,拆分出左旋物即得甲基多巴。
- Sigma Aldrich:555-30-6(sigmaaldrich)
- 用途二:该品为降压药。
- 上游原料:硫酸二甲酯 --> 香兰素 --> 苯甲醚 --> 硝基乙烷 --> 藜芦醛 --> 3,4-二甲氧基苯丙酮 --> DL-甲基多巴
- MOL 文件:555-30-6.mol