CAS 72-57-1 MFCD00003969-Trypan blue 台盼蓝 TAO{mole}

Trypan blue 台盼蓝

CAS 72-57-1 MFCD00003969

化学结构图

SMILES: Cc1cc(-c2ccc(/N=N/c3c(S(=O)(=O)[O-])cc4cc(S(=O)(=O)[O-])cc(N)c4c3O)c(C)c2)ccc1/N=N/c1c(S(=O)(=O)[O-])cc2cc(S(=O)(=O)[O-])cc(N)c2c1O.[Na+].[Na+].[Na+].[Na+]

化学属性

Mol. Formula	C34H24N6O14S4·4Na
Mol. Weight	961
Melting Point	300
TSCA	Yes
Solubility	10 G/L (25 ºC)
Density	1.007 g/mL at 20 °C
Appearance	蓝灰色粉状物，溶于水呈蓝色，微溶于溶纤纱，不溶于其他有机溶剂。遇浓硫酸为暗绿光蓝色，稀释后呈红光蓝色；遇浓硝酸呈棕光灰色溶液。其水溶液，遇10%硫酸为红色；遇氢氧化钠为红光紫色。

别名和识别编码

Chemical Name	Trypan Blue
Synonym	2,7-Naphthalenedisulfonicacid,3,3’-[[3,3’-dimethyl(1,1’-biphenyl)-4,4’-diyl]bis(azo)]bis(5-amino 2,7-naphthalenedisulfonicacid,3,3’-((3,3’-dimethyl-4,4’-biphenylylene)bis(azo 3,3'-DIMETHYL-4,4'-(BIPHENYLENEBISAZO)BIS(8-AMINO-1-NAPHTHOL)-3,6-DISULFONIC ACID TETRASODIUM SALT 3,3'-{[3,3'-二甲基-(1,1'-二苯基)-4,4'-二基]双(偶氮)}-双(5-氨基-4-羟基-2, 4,4'-BIS(8-AMINO-3,6-DISULFO-1-HYD Azurro diretto BENZO BLUE 3B Benzamine Blue 3B Benzanil Blue R Benzo Blue Benzo Blue 3B Bleu Bleu diazole N 3B Bleue diretto 3B Blue 3B Blue, Diamine Blue, Niagara Blue, Trypan Brasilamina Blue 3B C.I. 23850 C.I. 23850; Trypan Blue; Niagara Blue 3B; Tetrasodium 3,3'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[5-amino-4-hydro {PubChem
MDL Number	MFCD00003969
CAS Number	72-57-1
Beilstein Registry Number	4360496
EC Number	200-786-7
PubChem Substance ID	6296
Merck Number	9792
Chemical Name Translation	台盼蓝
Reaxys-RN	7125071
Wiswesser Line Notation	L66J BQ DSWQ HSWQ JZ CNUNR B D- 2 &-NA- 4
LabNetwork Molecule ID	LN01743703
InChI	InChI=1S/C34H28N6O14S4.4Na/c1-15-7-17(3-5-25(15)37-39-31-27(57(49,50)51)11-19-9-21(55(43,44)45)13-23(35)29(19)33(31)41)18-4-6-26(16(2)8-18)38-40-32-28(58(52,53)54)12-20-10-22(56(46,47)48)14-24(36)30(20)34(32)42;;;;/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4

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安全信息

Hazard statements

H226 Flammable liquid and vapour 易燃液体和蒸气
H350 May cause cancer 可能致癌
H351 Suspected of causing cancer 怀疑致癌

RTECSQJ6475000

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P302+P352+P332+P313+P362+P364
P303+P361+P353
P308+P313
P318
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

WGK Germany3

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S20 When using do not eat or drink 使用时，不得进食，饮水；
S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

Hazard Codes T

Storage condition Store at RT. 密封阴凉干燥保存。

UN Number 2811

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1275 mg/kg/34W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Blood - leukemia
REFERENCE :
   APHGBP Acta Pathologica (Belgrade).  (Belgrade Univerzitet, Institute de
   Pathologie, Belgrade, Yugoslavia)  V.2/3-    1938- Volume(issue)/page/year:
   33,1,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg/10W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 630 mg/kg/43W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BJEPA5 British Journal of Experimental Pathology.  (Blackwell Scientific
   Pub. Ltd., POB 88, Oxford, UK)  V.1-    1920-  Volume(issue)/page/year:
   33,524,1952

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg/6W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   AJPAA4 American Journal of Pathology.  (Lippincott/Harper, Journal
   Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    19

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 328 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,537,19

{haz

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 31,825,1934

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 31,825,1934

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF E

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 31,825,1934

{haza

TYPE OF TEST            : Body fluid assay
TEST SYSTEM             : Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 156,131,1985

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - hamster Liver
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 136,255,1984

{hazard_com

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 125 mg/kg
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5,488,1983

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Nether

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   CNJGA8 Canadian Journal of Genetics and Cytology.  (National Research
   Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
   Canada)  V.1-    1959-  Volume(issue)/page/year: 10,91,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 25 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetot

TYPE OF TEST            : TDLo - Low

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 mg/kg
SEX/DURATION            : female 8-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JOANAY Journal of Anatomy.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.51-    1916-  Volume(issue)/page/year: 100,361,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 100 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   JEZOAO Journal of Experimental Zoology.  (Alan R. Liss, Inc., 41 E. 11th
   St., New York, NY 10003) V.1-    1904-  Volume(issue)/page/year:
   171,343,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 66667 ug/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System

其他信息

蓝灰色粉状物，溶于水呈蓝色，微溶于溶纤纱，不溶于其他有机溶剂。遇浓硫酸为暗绿光蓝色，稀释后呈红光蓝色；遇浓硝酸呈棕光灰色溶液。其水溶液，遇10%硫酸为红色；遇氢氧化钠为红光紫色。
图谱信息:3,3'-{[3,3'-二甲基-(1,1'-二苯基)-4,4'-二基]双(偶氮)}-双(5-氨基-4-羟基-2,7-萘二磺酸)四钠盐(72-57-1)红外图谱(IR1) 3,3'-{[3,3'-二甲基-(1,1'-二苯基)-4,4'-二基]双(偶氮)}-双(5-氨基-4-羟基-2,7-萘二磺酸)四钠盐(72-57-1)红外图谱(IR2)
用途一:主要用于棉、麻、粘胶等纤维素纤维的染色，也可用于蚕丝、锦纶、粘/棉混仿纺的染色，还可用于纸张、皮革及生物染色。
色指数:23850
上游原料:硫酸钠
方法一:由3，3'-二甲基联苯胺用亚硝酸钠与盐酸重氮化后，在碱性介质中与H酸进行偶合，而后经盐析、过滤及干燥而得。公斤/吨3，3'-二甲基联苯胺（100%） 100H酸（100%） 345亚硝酸钠（100%） 72纯碱 380盐酸（31%） 490精盐 2700元明粉 33
海关编码:32041400
TCI Shanghai:直接蓝 14 Direct Blue 14(72-57-1)
Alfa Aesar:60% Trypan Blue, dye content >60%(72-57-1)" href="http://www.alfa.com/zh/GP100w.pgm?DSSTK=A18600&CAS;=72-57-1">台盼蓝,dyecontent>60% Trypan Blue, dye content >60%(72-57-1)
MOL 文件:72-57-1.mol
MSDS 信息:Direct Blue 14(72-57-1).msds
Acros Organics:锥虫蓝(台盼蓝) Trypan Blue(72-57-1)
Sigma Aldrich:72-57-1(sigmaaldrich)