CAS 79-57-2 MFCD00003700-Oxytetracycline 土霉素 TAO{mole}

Oxytetracycline 土霉素

CAS 79-57-2 MFCD00003700

化学结构图

SMILES: CN(C)C1C(=O)C(C(N)=O)=C(O)C2(O)C(=O)C3=C(O)c4c(O)cccc4C(C)(O)C3C(O)C12

化学属性

Mol. Formula	C22H24N2O9
Mol. Weight	460.43
Melting Point	183 °C
Appearance	淡黄色结晶性粉末。熔点182-182℃（分解）。微溶于乙醇，极微溶于水。在空气中稳定，遇光颜色渐暗，在碱性溶液中易破坏。吸附在碳酸钙中的制剂为黄褐色干燥粉末。盐酸盐为黄色结晶粉末，无臭，味微苦。熔点190-194℃，在室温下长期保存不变质，不失效。易溶于水和甲醇，略溶于乙醇，不溶于氯仿、乙醚。其水溶液在酸性条件下稳定，碱性条件下不稳定。
Solubility	0.2 g/L
Boiling Point	565.29 °C at 760 mmHg

别名和识别编码

Chemical Name	Oxytetracycline
Synonym	Oxytetracycline {LY} Oxytetracycline {} {LY} Oxytetracycline {} {} {LY} Oxytetracycline {} {} {} {LY} Oxytetracycline {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Oxytetracycline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Oxytetracycline
MDL Number	MFCD00003700
CAS Number	79-57-2
Beilstein Registry Number	2714587
EC Number	201-212-8
Chemical Name Translation	土霉素
Wiswesser Line Notation	L E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 KQ MQM1 RQ
LabNetwork Molecule ID	LN01291958
PubChem Substance ID	54675779
InChI	InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25-26,28,30,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1
Canonical SMILES	O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])[C@@H](O)[C@]3([H])[C@](C)(O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4)N

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安全信息

WGK Germany2

RTECSQI7875000

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Signal word Warning

GHS Symbol

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R36 Irritating to eyes 刺激眼睛
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P305+P351+P338

Hazard Codes Xn

{haz

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 260 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 1,501,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 5,1,1955

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 136 mg/kg
TOXIC EFFECTS :
   Musculoskeletal - changes in teeth and supporting structures
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,827,1962

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5706 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 20,793,1975

TYPE OF TEST

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 80 mg/kg/8D
REFERENCE :
   JOURAA Journal of Urology.  (Williams & Wilkins Co., 428 E. Preston St.,
   Baltimore, MD  21202) V.1-    1917-  Volume(issue)/page/year: 112,348,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 6-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi.  Journal of the Osaka City
   Medical Center.  (Osaka, Japan)  V.4-23, 1955-74.  For publisher
   information, see OIGZDE.  Volume(issue)/page/year: 14,107,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUT

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 gm/kg
SEX/DURATION            : female 6-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi.  Journal of the Osaka City
   Medical Center.  (Osaka, Japan)  V.4-23, 1955-74.  For publisher
   information, see OIGZDE.  Volume(issue)/page/year: 14,107,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 420 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   188,178,1964

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

可燃性危险特性:可燃, 火场排出氮氧化物辛辣刺激烟雾
用途三:土霉素的抗菌谱、抗菌原理与四环素基本相同。细菌对四环素、土霉素与金霉素之明月交叉耐药性。该品对肠道感染（包括阿米巴痢疾）的疗效较金霉素和四环素略好，其他适应症与四环素相同。
储运特性:库房低温, 通风, 干燥
类别:农药
毒性分级:中毒
方法一:由龟裂链霉菌（Streptomyces rimosus）发酵产生，在发酵液中加入碳酸钙，经过滤，将固体干燥而得。
急性毒性:口服- 大鼠 LD50: 4800 毫克/ 公斤; 口服- 小鼠 LD50: 2240 毫克/公斤
上游原料:碳酸钙 --> 淀粉 --> 草酸 --> 糊精
土霉素价格(试剂级):更新日期产品编号产品名称包装价格 2010/06/21 257705000 土霉素 Oxytetracycline , 'can be used as secondary standard' 500 MG 1399元
下游产品:盐酸多西环素 --> 盐酸土霉素 --> 强力霉素 --> 盐酸甲烯土霉素 --> 盐酸甲烯土霉素
用途一:属广谱抗菌素
参考质量标准:农业部标准(暂行) 水悬浮液(1+5)Ph 7.0～8.0 细度(过0.177 mm筛)/% 60 干燥失重/% ≤5.0 黄曲霉素/% ≤0.00001 重金属/% ≤0.002 砷(As)/% ≤0.0005
用途二:土霉素对革兰阳性菌和阴性菌均有抑制作用，也作为促进生长剂。用于2月龄以下的猪饲料，用量为15-50g/t；用于4月龄以下的猪饲料，用量为10-20g/t；用于鸡饲料，用量为5.0-50g/t，产蛋期禁用，停药期为7天。
比旋光度:-223 ° (c=1 0.03N HCl)
灭火剂:水, 二氧化碳, 干粉, 砂土
Sigma Aldrich:79-57-2(sigmaaldrich)
MOL 文件:79-57-2.mol
MSDS 信息:4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide(79-57-2).msds
方法二:土霉素是由龟裂状链丝菌的培养液中提取的广谱抗生素。
Acros Organics:土霉素/氧四环素 Oxytetracycline, 'can be used as secondary standard'(79-57-2)