CAS 20830-75-5 MFCD00003674-Digoxin 地高辛 TAO{mole}

Digoxin 地高辛

CAS 20830-75-5 MFCD00003674

化学结构图

SMILES: C[C@]12CC[C@@H](C[C@H]1CC[C@@H]1[C@@H]2C[C@@H](O)[C@]2(C)[C@H](CC[C@@]21O)C1COC(=O)C=1)O[C@H]1C[C@H](O)[C@H](O[C@H]2C[C@H](O)[C@H](O[C@H]3C[C@H](O)[C@H](O)[C@@H](C)O3)[C@@H](C)O2)[C@@H](C)O1

化学属性

Mol. Formula	C41H64O14
Mol. Weight	780.95
Melting Point	260-262
TSCA	Yes
Density	1.36

别名和识别编码

Chemical Name	Digoxin
CAS Number	20830-75-5
Synonym	Chloroformic digitalin Digoksyna Homolle's digitalin Rougoxin (3?,5?,12?)-3-[(O-2,6-Dideoxy-?-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-?-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-?-D-ribo-hexopyranosyl)oxyl]-12,14-dihydroxycard-20(22)-enolide L Digitalis glycoside SK-Digoxin Lanoxin Digacin Digoxigenin-tridigitoxosid Digoxine 异羟基洋地黄毒苷地高辛; 狄高辛; 异羟基洋地黄毒苷; 毛地黄叶毒苷 Lanicor Dilanacin
PubChem Substance ID	87568294
EC Number	244-068-1
Beilstein Registry Number	18(3/4)2453
MDL Number	MFCD00003674
Merck Number	3167
Chemical Name Translation	地高辛
Reaxys-RN	77011

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分类

Alphabetic, Analytical Standards, Analytical/Chromatography, Application Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Chemical Structure, Chromatography, Conjugates, D, DID - DIN, DIG-DY, Drug Efflux Pumps, Drugs & Metabolites, Drugs of Abuse, Enzymes, Inhibitors, and Substrates, Forensic and Veterinary Standards, Lipids, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Neat Compounds, Steroid,
{SNA} 1694 Pharmaceu

产品应用

一种强心苷（cardiac glycoside），为Pgp的底物，增强调控Pgp的表达和减弱调控SXR（类固醇源化学物受体）。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes T

Hazard statements

H300 Fatal if swallowed 吞食致命
H300+H330

Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

RTECSIH6125000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P301+P310+P330
P308+P313
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Safety Statements

S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S20 When using do not eat or drink 使用时，不得进食，饮水；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S22 Do not breathe dust 不要吸入粉尘；

UN Number 1544 3462 UN2811

Risk Statements

Packing GroupII

Storage condition 储存温度2-8℃

Restrict 剧毒化学品

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2947 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SIHSD8 Shang-hai I Hsueh.  (China International Book Trading Corp., POB
   2820, Beijing, Peop. Rep. China)  V.1-    1978(?)- Volume(issue)/page/year:
   4(2),32,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 13 ug/kg/4D-I
TOXIC EFFECTS :
   Behavioral - changes in psychophysiological tests
   Vascular - other changes
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AHJOA2 American Heart Journal.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 6314

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8900 ng/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Tr

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 109,279,1932

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROU

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - wo

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 810 ug/kg
SEX/DURATION            : female 1-18 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 121,1100,1975

Hazard Class6.1