CAS 68-96-2 MFCD00003659-Hydroxyprogesterone 羟孕酮 TAO{mole}

Hydroxyprogesterone 羟孕酮

CAS 68-96-2 MFCD00003659

化学结构图

SMILES: CC(=O)[C@@H]1CC[C@@H]2[C@H]3CCC4=CC(=O)CC(O)[C@@]4(C)[C@@H]3CC[C@]21C |&1:3,6,7,17,19,22|

化学属性

Mol. Formula	C21H30O3
Mol. Weight	330
Melting Point	217.0-221.0
Refractive index	90 ° (C=1, CHCl3)
Solubility	Soluble in water (partly), chloroform, methanol, and Dichloromethane.

别名和识别编码

Chemical Name	Hydroxyprogesterone
Synonym	17-HYDROXYPROGESTERONE 17-Hydroxypregn-4-en-3,20-dione 17ALPHA-HYDROXYPROGESTERONE Gestageno gador 17A-HYDROXYPROGESTERONE 17-Hydroxyprogesterone 4-pregnen-17a-ol-3,20-dione prodix 17α-Hydroxy-4-pregnene-3,20-dione gestagenogador 孕甾-4-烯-17α-醇-3,20-二酮 (17S)-17-Hydroxypregn-4-ene-3,20-dione 17a-hydroxypregn-4-ene-3,20-dione 17α-羟基黄体酮羟基黄体酮 17-Hydroxy-4-pregnene-3,20-dione 17Α-羟基孕烯二酮 17-羟基妊娠素 17α-羟基孕甾-4-烯-3,20-二酮 17α-羟基黄体酮 4-PREGNEN-17ALPHA-OL-3,20-DIONE 羟孕酮 17alpha-Hydoxyprogesterone 17β-Hydroxy-17-acetylandrosta-4-ene-3-one {ha
MDL Number	MFCD00003659
PubChem Substance ID	24278469
Beilstein Registry Number	3218109
CAS Number	68-96-2
EC Number	200-699-4
Chemical Name Translation	羟孕酮
Merck Number	4839
Reaxys-RN	3218109
InChIKey	DBPWSSGDRRHUNT-SJFWLOONSA-N
LabNetwork Molecule ID	LN00197016

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

一种长效孕激素

安全信息

RTECSTU5060000

GHS Symbol

Precautionary statements

P308+P313
P201 Obtain special instructions before use. 使用前获取专门指示。

Hazard statements

H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害

Hazard Codes T

WGK Germany3

Personal Protective Equipment Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S22 Do not breathe dust 不要吸入粉尘；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 5 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   ACEDAB Acta Endocrinologica, Supplementum (Copenhagen).  (Periodica,
   Skolegade 12 E, DK-2500 Valby, Denmark)  No.1-    1948-
   Volume(issue)/page/year: 28,18,1956

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Human - woman
DOSE                    : 65 mg/kg
SEX/DURATION            : female 8-32 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - gastrointestinal
   system
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 26,151,1960

其他信息

上游原料:薯蓣皂素
下游产品:6-亚甲基孕甾-4-烯-17Α-醇-3,20-二酮-17-醋酸酯 --> 醋酸甲地孕酮 --> 17-羟基孕甾-4-烯-3,20-二酮-17-醋酸酯 --> 17Α-乙酰氧基-6-二溴亚甲基孕甾-4-烯-3,20-二酮
用途二:氢化可的松、甲地孕酮、己酸孕酮的中间体。
方法一:可用薯蓣皂素经开环、乙酰化、氧化、水解、环氧化、氧化、加成、催化氢化等步反应制得。
用途一:用作甾体激素药中间体
MOL 文件:604-09-1.mol
MOL 文件:68-96-2.mol
Sigma Aldrich:68-96-2(sigmaaldrich)