CAS 63-05-8 MFCD00003615-Delta-4-Androstene-3,17-Dione 雄烯二酮 TAO{mole}

Delta-4-Androstene-3,17-Dione 雄烯二酮

CAS 63-05-8 MFCD00003615

化学结构图

SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=O

化学属性

Mol. Formula	C19H26O2
Mol. Weight	286.45
Melting Point	170-173°C
Density	1.11

别名和识别编码

Chemical Name	Delta-4-Androstene-3,17-Dione
Synonym	(+)-4-ANDROSTEN-3,17-DIONE (8R,9S,10R,13S,14S)-10,13-DIMETHYL-1,6,7,8,9,10,11,12,13,14,15,16-DODECAHYDRO-2H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIONE 10,13-DIMETHYL-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIONE 10,13-二甲基-2,3,6,7,8,9,10,11,12,13,14,15,16,17-十四氢-1H-环戊烷并[A]菲-3,17-二酮 3,17-DIOXO-4-ANDROSTENE 3,17-Dioxoandrost-4-Ene 4 Androstene 3,17 dione 4-AD 4-AD,4-雄烯二酮 4-ANDROSTEN-3,17-DIONE 4-ANDROSTENE-3,17-DIONE 4-ANDROSTENEDIONE 4-Androstene-3,17-dione 4-雄(甾)烯-3,17-二酮 4-雄(甾)烯-3,17-二酮/雄烯二酮 4-雄烯-3,17-二酮 4-雄烯二酮 ANDROST-4-ENE-3, 17-DIONE ANDROST-4-ENE-3,17-DIONE, 10,13-DIMETHYL-2,6,7,8,9,11,12,14,15,16-DECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIONE ANDROSTA
MDL Number	MFCD00003615
CAS Number	63-05-8
Beilstein Registry Number	2059239
EC Number	200-554-5
PubChem Substance ID	6128
Chemical Name Translation	雄烯二酮
Merck Number	13,643
Wiswesser Line Notation	L E5 B666 FV OV MUTJ A1 E1
InChI	InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

睾酮和带有雄激素活性代谢产物的前体,可能会增加前列腺癌(prostate cancer)或胰腺癌(pancreatic cancer)的风险。

安全信息

WGK Germany3

RTECSBV8150000

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Storage condition 储存温度2-8℃

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg/9W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   19,977,1957

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7 mg/kg
SEX/DURATION            : female 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 5,489,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5056 ug/kg
SEX/DURATION            : female 16 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 56,675,1979

TYPE OF TEST            : TDLo - Lowest pu

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcuta

TYPE OF TEST            :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 35 mg/kg
SEX/DURATION            : female 1-4 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   80,1152,1967

Hazard statements

H302 Harmful if swallowed 吞食有害
H351 Suspected of causing cancer 怀疑致癌
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
H362 May cause harm to breast-fed children 可能对母乳喂养的婴儿造成伤害

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P308+P313
P330 Rinse mouth. 漱口
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

其他信息

图谱信息:雄烯二酮(63-05-8)质谱(MS) 雄烯二酮(63-05-8)核磁图( 13 CNMR) 雄烯二酮(63-05-8)红外图谱(IR1)
Sigma Aldrich:63-05-8(sigmaaldrich)
储运特性:库房通风低温干燥
TCI Shanghai:d4-雄烯-3,17-二酮 DELTA4-Androstene-3,17-dione,>;99.0%(GC)(63-05-8)
MSDS 信息:Androstenedione(63-05-8).msds
Acros Organics:4-雄(甾)烯-3,17-二酮/雄烯二酮 4-androstene-3,17-dione(63-05-8)
用途一:用作甾体激素药中间体
MOL 文件:63-05-8.mol
灭火剂:干粉、泡沫、砂土、二氧化碳,雾状水
下游产品:螺内酯
可燃性危险特性:可燃; 燃烧产生刺激烟雾
类别:有毒物品