CAS 646-06-0 MFCD00003207-1,3-Dioxolane 1,3-二氧环戊烷 TAO{mole}

1,3-Dioxolane 1,3-二氧环戊烷

CAS 646-06-0 MFCD00003207

化学结构图

SMILES: C1COCO1

化学属性

Mol. Formula	C3H6O2
Mol. Weight	74.08
Density	1.06
Refractive index	1.3980 to 1.4020
Flash Point	-4°C(lit.)
TSCA	Yes
Melting Point	-95
Boiling Point	75-76
Autoignition Point	525 °F
Vapor Density	2.6 (vs air)
Vapor Pressure	70 mmHg ( 20 °C)
Solubility	Soluble in Chloroform, Dichloromethane, Ethanol, Ethyl Acetate and Methanol.
Stability	对热和空气敏感

别名和识别编码

Chemical Name	1,3-Dioxolane
Synonym	(1,3)dioxolane 1,3-Dioxacyclopentane, Glycolformal 1,3-Dioxacyclopentane; Ethylene glycol methylene ether; Formaldehyde ethylene acetal 1,3-Dioxolan 1,3-dioxole, dihydro- 1,3-二噁戊烷 1,3-二噁烷, 99.5%, STAB. 1,3-二氧杂环戊烷 1.3-Dioxacyclopentane 1，3-二氧戊环 Ethylene glycol formal GLYCOLFORMAL [1,3]Dioxolane dihydro-1,3-dioxole dihydro-3-dioxole dioxolanne ethyleneglycolformal formaldehyde ethylene acetal 乙二醇次甲基醚乙二醇缩甲醛二氧戊环亚乙二醇亚甲醚
CAS Number	646-06-0
EC Number	211-463-5
Beilstein Registry Number	102453
MDL Number	MFCD00003207
PubChem Substance ID	12586
Chemical Name Translation	1,3-二氧环戊烷
Reaxys-RN	102453
Wiswesser Line Notation	T5O COTJ
LabNetwork Molecule ID	LN00164132
InChI	InChI=1S/C3H6O2/c1-2-5-3-4-1/h1-3H2

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产品应用

用作低沸点化合物的溶剂，及油脂、蜡、染料及纤维衍生物的萃取剂

安全信息

Signal word Danger

GHS Symbol

WGK Germany1

Safety Statements

S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；

Risk Statements

R11 Highly flammable 非常易燃
R36 Irritating to eyes 刺激眼睛

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338+P337+P313
P308+P313
P370+P378
P403+P235
P501 Dispose of contents/container to..… 处理内容物/容器.....

Packing GroupII

UN Number 1166

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
H319 Causes serious eye irritation 严重刺激眼睛

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)

RTECSJH6760000

Hazard Codes 3 F

Hazard Class3

Storage condition 储藏温度2-8℃,充氩保存 Refrigerator 储存温度2-8℃ 0-10°C 0-10

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20650 mg/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,70,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 31,60,1949

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 32000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 12/17/1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 8480 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 12/17/1971

TYP

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       :

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 290 mg/kg
REFERENCE :
   STBIBN Studia Biophysica.  (Akademie-Verlag GmbH, Postfach 1233, Berlin
   DDR-1086, Ger. Dem. Rep.) V.1-    1966-  Volume(issue)/page/year:
   107,205,1985

其他信息

方法一:由多聚甲醛与乙二醇反应而得。多聚甲醛与乙二醇以1：1.25摩尔比投入反应釜中，用强酸性离子交换树脂作催化剂，在90-110℃进行常压反应。从蒸馏柱顶部馏出70-74℃共沸物，经氯化钠盐析及无水氯化钙脱水后，再进行蒸馏提纯，切取71-74℃馏分，用分子筛将水分脱至200ppm，即得成品。另一种操作是使多聚甲醛与乙二醇在浓硫酸存在下反应，经氯化钠盐析、固碱干燥，精馏得到产品。原料消耗定额：多聚甲醛（93-95%）750kg/t、乙二醇200kg/t。
毒性分级:中毒
海关编码:29329970
Sigma Aldrich:646-06-0(sigmaaldrich)
灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
类别:易燃液体
MSDS 信息:1,3-二氧戊环(646-06-0).msds
用途二:该品是共聚甲醛的第二单体，与三聚甲醛以95：5的比例进行共聚以生产共聚甲醛。该品也作为溶剂使用，也是丝绸整理剂及封口用胶。
急性毒性:口服- 大鼠 LD50: 3000 毫克/ 公斤; 口服- 小鼠 LD50: 3200 毫克/ 公斤
TCI Shanghai:1,3-二氧戊环(含稳定剂三乙胺) 1,3-Dioxolane (stabilized with Triethylamine),>;98.0%(GC)(646-06-0)
MOL 文件:646-06-0.mol
Alfa Aesar:1,3-二烷,99.5%,stab. 1,3-Dioxolane, 99.5%, stab.(646-06-0)
蒸气压:70 mm Hg ( 20 °C)
图谱信息:1,3-二氧戊环(646-06-0)核磁图( 1 HNMR) 1,3-二氧戊环(646-06-0)红外图谱(IR1) 1,3-二氧戊环(646-06-0)质谱(MS) 1,3-二氧戊环(646-06-0)核磁图( 13 CNMR) 1,3-二氧戊环(646-06-0)Raman光谱
职业标准:TWA 10 毫克/ 立方米; STEL 50 毫克/ 立方米
Acros Organics:1,3-二氧戊环 1,3-Dioxolane, stabilized, 99+%(646-06-0)
用途一:主要用作油和脂肪的溶剂、提取剂，锂电池的电解溶剂，氯基溶剂稳定剂，药物中间体等
刺激数据:皮肤- 兔子 530 毫克轻度; 眼睛- 兔子 750 微克重度
上游原料:氢氧化钠 --> 多聚甲醛
蒸气密度:2.6 (vs air)
可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产生刺激烟雾
1,3-二氧戊环价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 D0861 1,3-二氧戊环(含稳定剂三乙胺) 1,3-Dioxolane (stabilized with Triethylamine) 25ML 114元 2014/06/02 D0861 1,3-二氧戊环(含稳定剂三乙胺) 1,3-Dioxolane (stabilized with Triethylamine) 500ML 406元 2010/06/21 180195000 1,3-二氧戊环 1,3-Dioxolane 99+%, stabilized 500 GR 696元
能与水混溶，溶于醇，醚和苯。与水形成的共沸物，含水6.7%。能使溴水脱色。
外观性质:水白色液体。
储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
下游产品:4,5,6,7-四氢噻吩[3,2-c]吡啶盐酸盐 --> 2-((乙酰氧基)甲氧基)乙醇乙酸酯