CAS 83-07-8 MFCD00003145-4-Aminoantipyrine 4-氨基安替比林 TAO{mole}

4-Aminoantipyrine 4-氨基安替比林

CAS 83-07-8 MFCD00003145

化学结构图

SMILES: Cc1c(N)c(=O)n(-c2ccccc2)n1C

化学属性

Mol. Formula	C11H13N3O
Mol. Weight	203
Melting Point	105-110
Density	0.800
TSCA	Yes
Solubility	Soluble in water (50 mg/ml).
Stability	对光、湿度和空气敏感

别名和识别编码

Chemical Name	4-Aminoantipyrine
CAS Number	83-07-8
Synonym	######## 1,5-二甲基-2-苯基-4-氨基-3-吡唑啉酮 1-PHENYL-2,3-DIMETHYL-4-AMINO-3-PYRAZOLIN-5-ON 3-Pyrazolin-5-one, 4-amino-2,3-dimethyl-1-phenyl- 4 Amino 1,5 Dimethyl 2 Phenyl 3H Pyrazolone 4 Aminoantipyrine 4 Aminophenazone 4-AMINO-1,3-DIMETHYL-2-PHENYL-3-PYRAZOLONE 4-AMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-PYRAZOL-3-ONE 4-AMINO-2,3-DIMETHYL-1-PHENYL-3-PYRAZOLINE-5-ONE 4-AMINOANTIPYRINE 4-AMINOPHENAZONE 4-Amino-1,5-Dimethyl-2-Phenyl-3H-Pyrazolone 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one 4-Aminoantipyrine 4-Aminophenazone 4-Amminoantipirina 4-氨基-1,2-二氢-1,5-二甲基-2-苯基-3H-吡唑-3-酮 4-氨基-1,5-二甲基-2-苯基-3-吡唑啉酮 4-氨基安替吡啉 4-氨基安替比林 4-氨基安替比林；4-氨基非那宗；4-氨基-1,5-二甲基-2-苯基-3-吡唑啉酮 4-氨基非那宗 4-胺-1,5-二甲-2-苯-3H-吡唑-3-酮
PubChem Substance ID	87561316
EC Number	201-452-3
Beilstein Registry Number	181635
MDL Number	MFCD00003145
Reaxys-RN	181635
Merck Number	591
Chemical Name Translation	4-氨基安替比林
Wiswesser Line Notation	T5NNVJ A1 BR& DZ E1
LabNetwork Molecule ID	LN00193860
InChI	InChI=1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3

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分类

{SNA} Deriva
{SNA} 2009/48/EC (Directive on the Safety of Toys), APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Standards, Analytical Standards, Chromatogr
{SNA} 2009/48/EC (Directive on the Safety of Toys), APIs & Metabolites, APIs (Active Pharmaceutical Ingredients) & Metabolites, Additional Standards, Analytical Standards, Chromatography, European Community: ISO, DIN and DL 152, Metamizol Metabolites, Method and Regulation Specific, Pharmaceutical Standards, 分析/色谱
{SNA} Derivatization Reagents, Derivatization Reagents HPLC, Derivatization Reagents TLC, Peroxides, Phenols, Spectroscopy,
{SNA} A-B, Puriss p.a.,
{SNA} A-B, Puris

产品应用

A reagent for glucose determination in the presence of peroxidase and phenol

安全信息

GHS Symbol

WGK Germany3

Hazard Codes Xn

Hazard statements

H302 Harmful if swallowed 吞食有害
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

RTECSCD2480000

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312
P301+P312+P330
P302+P352
P302+P352+P332+P313+P362+P364
P304+P340
P305+P351+P338
P305+P351+P338+P337+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Warning

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Storage condition 密封阴凉保存。 Store at RT. 密封阴凉避光保存。

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCFAAI Bollettino Chimico Farmaceutico.  (Societa Editoriale Farmaceutica,
   Via Ausonio 12, 20123 Milan, Italy)  V.33-    1894- Volume(issue)/page/year:
   117,638,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 10,820,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 99,171,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CCCCAK Collection of Czechoslovak Chemical Communications.  (Academic Press
   Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK)  V.1-    1929-
   Volume(issue)/page/year: 47,636,1982

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 312 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 133,161,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 206,317,1988

其他信息

4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.
Alfa Aesar:4-氨基安替比林,97% 4-Aminoantipyrine, 97%(83-07-8)
毒性分级:中毒
F:8-9-23
用途三:医药安乃近的中间体。
下游产品:氨基比林 --> 1-苯基-2,3-二甲基-4-甲氨基吡啶唑酮-[5]-N-甲基磺酸钠-水合物
Hazard Note:Harmful
可燃性危险特性:可燃;燃烧产生有毒氮氧化物烟雾
类别:有毒物品
TCI Shanghai:4-氨基安替比林 4-Aminoantipyrine,>;99.0%(T)(83-07-8)
存储注意事项:光敏感
外观性质:黄色结晶粉末
急性毒性:口服-大鼠LD50: 1700 毫克/公斤; 口服-小鼠LD50: 800 毫克/公斤
储运特性:库房通风低温干燥
用途一:用作药物安乃近的中间体
图谱信息:4-氨基安替比林(83-07-8)红外图谱(IR2) 4-氨基安替比林(83-07-8)红外图谱(IR1) 4-氨基安替比林(83-07-8)核磁图( 13 CNMR) 4-氨基安替比林(83-07-8)质谱(MS) 4-氨基安替比林(83-07-8)核磁图( 1 HNMR)
方法一:安替比林经亚硝酸钠亚硝化，经亚硫酸氢铵与亚硫酸铵还原，经硫酸水解，最后用液氨中和，得到4-氨基安替比林。工艺过程如下：安替比林与50%硫酸配成溶液，其中含安替比林38%-40%、含硫酸11%-12%。将此溶液与亚硝酸钠溶液同时流入亚硝化反应器，控制两者的流量，控制反应温度45-50℃，搅拌下反应，并用碘粉淀粉试纸测反应终点以调节水流量。亚硝化生成的亚硝基安替比林立即流入还原罐，与罐内配好的还原剂亚硫酸氢铵与亚硫酸铵的水溶液反应。取样测pH值及还原度，pH值在5.4-5.8之间，还原度约为15（即1ml还原液消耗0.1N碘液的毫升数）。还原结束后，pH值调节至5.8-6.0，还原度为5左右。升温至100℃，水解3h。降温至80℃，用液氨中和至pH7-7.5，静置分层。分去废水，得4-氨基安替比林油（含量80%以上）。将其压入结晶罐，搅拌、冷却结晶、过滤，得4-氨基安替比林。收率96%。
MSDS 信息:4-氨基安替比林(83-07-8).msds
4-氨基安替比林价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 C103150250 4-氨基安替比林;1,5-二甲基-2-苯基-4-氨基-3-吡唑啉酮;4-氨基非那宗;4-氨基-2,3-二甲基-1-苯基-5-吡唑啉酮 25g 289元 2011/08/23 30006460 4-氨基安替比林;1,5-二甲基-2-苯基-4-氨基-3-吡唑啉酮;4-氨基非那宗;4-氨基-2,3-二甲基-1-苯基-5-吡唑啉酮 25g 14元 2011/08/23 30006414 4-氨基安替比林;1,5-二甲基-2-苯基-4-氨基-3-吡唑啉酮;4-氨基非那宗;4-氨基-2,3-二甲基-1-苯基-5-吡唑啉酮 25g 14元
用途二:用于检定醇与胺类，测大气及水中酚类化合物
海关编码:29331190
Acros Organics:4-氨基安替比林 4-Aminoantipyrine, 98%(8
Sigma Aldrich:83-07-8(sigmaaldrich)
对光和空气敏感。溶于水、苯和乙醇，微溶于乙醚。在碱性条件及氧化剂存在下，与酚类化合物反应生成红色燃料。低毒，半数致死量(大鼠，经口)1700mg/kg。有刺激性。
灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
MOL 文件:83-07-8.mol