CAS 603-35-0 MFCD00003043-Triphenylphosphine 三苯基膦 TAO{mole}

Triphenylphosphine 三苯基膦

CAS 603-35-0 MFCD00003043

化学结构图

SMILES: c1ccc(P(C2CCCCC2)C2CCCCC2)cc1

化学属性

Mol. Formula	C18H15P
Mol. Weight	262.29
Density	1.132
Vapor Density	9 (vs air)
Boiling Point	260°C/25mmHg(lit.)
Vapor Pressure	5 mmHg ( 20 °C)
Melting Point	80.0 to 82.0 deg-C
Flash Point	181°(358°F)
TSCA	Yes
Solubility	Soluble in ether, acetone, chloroform (50 mg/ml), and alcohol. Insoluble in water.
Stability	对光敏感
Appearance	white xtl.
Danger-Level	乙类
pH	-:-
Redox	-

别名和识别编码

Chemical Name	Triphenylphosphine
MDL Number	MFCD00003043
CAS Number	603-35-0
EC Number	210-036-0
Beilstein Registry Number	610776
Synonym	Triphenylphosphine {LY} Triphenylphosphine phosphine,triphenyl triphenyl-phosphane triphenyl-phosphin triphenylphosphine triphenylphosphine hydrobromide triphenylphosphine hydrochloride {} {LY} Triphenylphosphine {} {} {LY} Triphenylphosphine {} {} {} {LY} Triphenylphosphine {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Triphenylphosphine {} {} {} {} {} {}
Merck Number	9743
PubChem Substance ID	11776
Chemical Name Translation	三苯基膦
Reaxys-RN	610776
Wiswesser Line Notation	RPR&R
LabNetwork Molecule ID	LN00198869
InChI	InChI=1S/C18H15P/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
Canonical SMILES	P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

用于有机合成，聚合引发剂，抗菌素类药物氯洁霉素的原料，有机微量分析测定磷的标准样品。

安全信息

Signal word Warning

GHS Symbol

WGK Germany2

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24 Avoid contact with skin 避免皮肤接触；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S37 Wear suitable gloves 戴适当手套；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R48/20/22
R53 May cause long-term adverse effects in the aquatic environment 对水生环境有长期的有害作用

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P301+P312+P330
P302+P350
P302+P352
P302+P352+P333+P313+P362+P364
P304+P312
P304+P340
P304+P340+P312
P305+P351+P338
P305+P351+P338+P337+P313
P308+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P333+P313
P337+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害
H302+H332
H312 Harmful in contact with skin 皮肤接触有害
H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛
H332 Harmful if inhaled 吸入有害
H335 May cause respiratory irritation 可能导致呼吸道刺激
H350 May cause cancer 可能致癌
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSSZ3500000

Hazard Codes Xn

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {}

UN Number

Warnings 危化品目录(2015)

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1135 ppm/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AIHAM* Annual Meeting of American Industrial Hygiene Association.  (Akron,
   OH)  For publisher information, see AIHAAP.  Volume(issue)/page/year:
   -,-,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-0384-0014

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Tech

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Subs

Packing GroupIII

Restrict -

其他信息

方法二:溴苯经格式反应后，用三氯化磷进行膦化反应得到三苯膦。
用途一:用于有机合成，也用作聚合引发剂、抗菌素类药物氯洁霉素等的原料
灭火剂:二氧化碳、砂土、水、泡沫
无气味。摩擦
检测方法:GC
参考质量标准:外观白色结晶体三苯基膦含量wt%≥99.7 三苯基氧膦含量wt%≤0.3 硫(S)PPM ＜5 氯(Cl)PPM ＜15 钠(Na)PPM ＜5 镁(Mg)PPM ＜5 铁(Fe)PPM ＜10 灰份PPM ＜100 干燥失重% ＜0.5 熔点℃ ≥78.5-81.5 溶解性溶解于氯仿、乙酸和苯 4%四氯化碳溶液透光率%≥95
急性毒性:口服-大鼠 LD50: 700 毫克/公斤; 口服-小鼠 LD50: 1000 毫克/公斤
图谱信息:三苯基膦(603-35-0)Raman光谱三苯基膦(603-35-0)红外图谱(IR1) 三苯基膦(603-35-0)红外图谱(IR2) 三苯基膦(603-35-0)红外图谱(IR3) 三苯基膦(603-35-0)核磁图( 13 CNMR) 三苯基膦(603-35-0)质谱(MS) 三苯基膦(603-35-0)核磁图( 1 HNMR)
蒸气密度:9 (vs air)
可燃性危险特性:受热分解有毒磷化物
{Chemica
用途三:用于有机合成，聚合引发剂，抗菌素类药物氯洁霉素的原料，有机微量分析测定磷的标准样品。
Acros Organics:三苯基
海关编码:29310095
刺激数据:皮肤-兔子 500 毫克/24小时重度; 眼睛-兔子 500 毫克/24小时轻度
蒸气压:5 mm H
弗里德尔-克拉夫茨法:最佳反应条件：催化剂用量48g、反应时间8h、反应温度400℃，收率达63.5%。以硫、三氯化磷和苯直接回流反应，生成三苯基硫膦化合物，再经铁粉还原得三苯基膦。
储运特性:库房通风低温干燥; 与食品
类别:有毒物品
用途二:在农药上用于酯交换法合成有机磷中间体亚磷酸三甲酯，进而可得到敌敌畏、久效磷、磷胺等一系列有机磷杀虫剂，此外，它可用作合成橡胶和树脂的稳定剂、聚氯乙烯的抗氧剂，用作合成醇酸树脂和聚酯树脂的原料。
下游产品:头孢克肟 --> 2-(二苯基膦基)乙胺 --> 齐多夫定 --> 5-苯基噻吩-2-羧酸 --> 硫酸长春地辛 --> 三苯基膦氯化钌 --> 2-二苯基膦-6-甲基吡啶 --> 反式-2-辛烯-1-醇 --> 5 5'-二甲基-2,2-联吡啶 --> 联萘二溴 --> N-(2-羟基乙基)-2-[4-(2-甲基丙基)苯基]丙酰胺 --> 3-溴异烟酸 --> 丁-3-炔-1-胺 --> 5-苯基-2-噻吩甲醛 --> (1-戊基)三苯基溴化磷 --> 二溴三苯基膦 --> 多虑平 --> 双(三苯基膦)氯化镍 --> 3-溴-2-吡啶羧酸 --> 拉西地平 --> 阿伐斯汀 --> 1,2-二(二苯基膦基)乙烷二氯化钯(II) --> N-BOC-6-溴代己胺 --> 异维 A 酸 --> 3-苯基吡唑 --> AE-活性酯 --> (甲氧基甲基)三苯基氯化 --> 乙基三苯基醋酸膦 --> 依维菌素 --> 甲基三苯基溴化
方法一:其制备方法是以苯酚与三氯化磷为原料，经酯化反应后再经减压蒸馏，即得到产品亚磷酸三苯酯。 3C 6 H 5 OH+PCl 3 [15～20℃]→(C 3 H 5 O) 3 P+3HCl 具体工艺分间歇法和连续法两种。 (1)间歇法将苯酚加入反应器中，温热熔化后加入三氯化磷，与苯酚在70～90℃开始反应，三氯化磷加完后，反应混合物温度将上升到150℃左右；在高温下减压除去溶解的氯化氢和未反应的苯酚，即得产品。 (2)采用塔式反应器使苯酚从塔的上部冷凝器下方进入，三氯化磷从塔的下部接受器上方进入。二者在塔中进行反应，产物收集在接受器中，副产物氯化氢经冷凝器上端引入吸收塔。粗酯经蒸馏等处理即得产品。
毒性分级:中毒