CAS 13073-35-3 MFCD00002626-(S)-2-Amino-4-(ethylthio)butanoic acid L-乙硫氨酸 TAO{mole}

(S)-2-Amino-4-(ethylthio)butanoic acid L-乙硫氨酸

CAS 13073-35-3 MFCD00002626

化学结构图

SMILES: CCSCCC(N)C(O)=O

化学属性

Mol. Formula	C6H13NO2S
Mol. Weight	163.24
Melting Point	280 °C (dec.) (lit.)

别名和识别编码

Chemical Name	(S)-2-Amino-4-(ethylthio)butanoic acid
CAS Number	13073-35-3
Synonym	L-乙硫氨基酪酸 ETH L-2-氨基-4-(乙硫基)丁酸 L-Ethionine L-2-Amino-4-(ethylthio)butyric acid S-Ethyl-L-homocysteine L-Homocysteine, S-ethyl- Ethionine
MDL Number	MFCD00002626
PubChem Substance ID	87569352
EC Number	235-966-4
Reaxys-RN	1722528
Beilstein Registry Number	4(3)1643
Merck Number	3738
Chemical Name Translation	L-乙硫氨酸
Wiswesser Line Notation	QVYZ2S2

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产品应用

Ethionine-induced inhibition of protein synthesis and lowering of ATP level in the liver.

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P305+P351+P338
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。

Signal word Warning

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

RTECSES6825300

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xi

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44100 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Liver - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 7,1143,1986

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 5 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 4,291,1983

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   CGCGBR Cytogenetics and Cell Genetics.  (S. Karger Pub., Inc., 79 Fifth
   Ave., New York, NY 10003) V.12-    1973-  Volume(issue)/page/year:
   44,209,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   520,139,1978

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 8,1059,1987

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   BBACAQ Biochimica et Biophysica Acta.  (Elsevier Science Pub. B.V., POB 211,
   1000 AE Amsterdam, Netherlands)  V.1-    1947- Volume(issue)/page/year:
   520,139,1978

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 gm/L
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/year: 50,387,1985