3,3',5-Triiodo-L-thyronine 3,3',5-三碘代-L-甲腺原氨酸/T3
CAS 6893-02-3 MFCD00002593
化学结构图
SMILES: N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O
化学属性
| Mol. Formula | C15H12I3NO4 |
|---|---|
| Mol. Weight | 651 |
| Melting Point | 234-238 |
| TSCA | No |
别名和识别编码
| Chemical Name | 3,3',5-Triiodo-L-thyronine |
|---|---|
| Synonym | 3,3′,5-三碘甲状腺氨酸 (T3) 3,5,3'-Triiodothyronine L-3-(4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine L-Liothyronine L-Triiodothyronine L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo- Liothyronin O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine T3 T3 (Hormone) T3 (amino acid) Thyronine, 3,3',5-triiodo-, L- Tresitope Triiodo-L-thyronine |
| CAS Number | 6893-02-3 |
| PubChem Substance ID | 87576399 |
| EC Number | 229-999-3 |
| Beilstein Registry Number | 2710227 |
| MDL Number | MFCD00002593 |
| Reaxys-RN | 2710227 |
| Merck Number | 5510 |
| Chemical Name Translation | 3,3',5-三碘代-L-甲腺原氨酸/T3 |
| Wiswesser Line Notation | QVYZ1R CI EI DOR DQ CI |
| LabNetwork Molecule ID | LN00193201 |
| InChI | InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
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分类
- {SNA} Cytokines, Growth Factors and Hormones, Hormones, Other Protein/Peptide Hormones, Peptides and Proteins, Peptides for Cell Biology, Thyroid Hormones, Triiodo-L-Thyronine (T3), 细胞信号转导和神经科学, 细胞生物学
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, T, TP - TZ
- {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, T, TP - TZ
- Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines,
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards,
相关文献及参考
- [2]. Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92.
- Adams, A.C., et al., Thyroid Hormone Regulates Hepatic Expression Of Fibroblast Growth Factor 21 In A PPARalpha-dependent Manner. J. Bacteriol. 285 , 14075-82, (2010) 摘要
- Adams, A.C., et al., Thyroid Hormone Regulates Hepatic Expression Of Fibroblast Growth Factor 21 In A PPARalpha-dependent Manner. J. Bacteriol. 285 , 14078-82, (2010) 摘要
- Adams, A.C., et al., Thyroid Hormone Regulates Hepatic Expression Of Fibroblast Growth Factor 21 In A PPARalpha-dependent Manner. J. Thorac. Cardiovasc. Surg. 285 , 14078-82, (2010) 摘要
- Beil. 14 ,IV,2373
- Corp MSDS 1 (2), 3467:A / FT-NMR 1 (2), 1186:A / RegBook 1 (2), 1845:C / Sigma FT-IR 1 (1), 730:B / Structure Index 1 , 295:C:8
- Merck 14 ,5510
- Tiefenbach, J., et al., A Live Zebrafish
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S37 Wear suitable gloves 戴适当手套；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- Volume(issue)/page/year: 32,197,1981
{hazTYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE : 75 ug/kg SEX/DURATION : female 3 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 11,529,1974
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 1400 ug/kg SEX/DURATION : female 16-22 day(s) after concepti
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 300 ug/kg SEX/DURATION : female 19-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 12,162,1989
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Mammal - domestic DOSE : 300 ug/kg SEX/DURATION : female 30 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Endocrine - changes in growth hormone REFERENCE : THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 197
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES
