CAS 530-78-9 MFCD00002422-Flufenamic acid 氟灭酸 TAO{mole}

Flufenamic acid 氟灭酸

CAS 530-78-9 MFCD00002422

化学结构图

SMILES: O=C(O)c1ccccc1Nc1cccc(C(F)(F)F)c1

化学属性

Mol. Formula	C14H10F3NO2
Mol. Weight	281.23
Melting Point	132-135 °C
TSCA	No
Solubility	0.0265 G/L (37 ºC)
Density	1.422
Appearance	淡黄色针状结晶。熔点125℃。溶于50%乙醇。
Boiling Point	373.9°C at 760 mmHg
Flash Point	179.9°C

别名和识别编码

Chemical Name	Flufenamic acid
CAS Number	530-78-9
Synonym	Flufenamic acid {LY} Flufenamic acid {} {LY} Flufenamic acid {} {} {LY} Flufenamic acid {} {} {} {LY} Flufenamic acid {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Flufenamic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number	MFCD00002422
EC Number	208-494-1
Merck Number	4132
Beilstein Registry Number	1996069
PubChem Substance ID	3371
Alfabeta Name	TRIFLUOROMETHYLPHENYLAMINOBENZOICACID 23[]()--{}
Reaxys-RN	1996069
Chemical Name Translation	氟灭酸
Wiswesser Line Notation	QVR BMR CXFFF
LabNetwork Molecule ID	LN00179078
InChI	InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)
Canonical SMILES	O=C(O)C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

Anti-inflammatory; analgesic.

安全信息

RTECSCB4375000

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Packing GroupIII

UN Number 2811 UN 2811 6.1/PG 3

Risk Statements

R22 Harmful if swallowed 吞咽有害
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性

GHS Symbol

WGK Germany3

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P310+P330
P301+P316
P302+P352
P302+P352+P332+P313+P362+P364
P304+P340
P305+P351+P338
P305+P351+P338+P337+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Hazard statements

H301 Toxic if swallowed 吞食有毒
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes 6.1 Xn

Warnings IRRITANT

Hazard Class6.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 98 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMROCX Current Medical Research and Opinion.  (Clayton-Wray Pub. Ltd., 1a
   High St., Alton, Hants., UK)  V.1-    1972-  Volume(issue)/page/year:
   4,17,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2160 mg/kg/26W-I
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   PGMJAO Postgraduate Medical Journal.  (Blackwell Scientific Pub. Ltd., POB
   88, Oxford, UK) V.1-    1925-  Volume(issue)/page/year: 62,773,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 249 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 221,132,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 620 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 18,845,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Human
DOSE/DURATION           : 504 mg/kg/8W
REFERENCE :
   STBIBN Studia Biophysica.  (Akademie-Verlag GmbH, Postfach 1233, Berlin
   DDR-1086, Ger. Dem. Rep.) V.1-    1966-  Volume(issue)/page/year:
   50,172,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1 gm/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   FESTAS Fertility and Sterility.  (American Fertility Soc., 608 13th Ave. S,
   Birmingham, AL 35282) V.1-    1950-  Volume(issue)/page/year: 38,238,1982

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

上游原料:乙醇 --> 盐酸 --> N,N-二甲基甲酰胺 --> 氢氧化钾 --> 溴乙烷 --> 铜 --> 1,4-氧氮六环 --> N,N-二甲基乙酰胺 --> 2-氯苯甲酸 --> 间氨基三氟甲苯 --> 醋酸铜 --> 2-碘苯甲酸
图谱信息:氟灭酸(530-78-9)红外图谱(IR2) 氟灭酸(530-78-9)Raman光谱氟灭酸(530-78-9)红外图谱(IR1) 氟灭酸(530-78-9)质谱(MS)
Alfa Aesar:氟芬那酸,97% Flufenamic acid, 97%(530-78-9)
氟芬那酸:氟芬那酸是目前常用的一种非激素类的消炎镇痛药物，是氟灭酸的另一种叫法，常温下为淡黄色或淡黄绿色的结晶或结晶性粉末，味苦。几乎不溶于水，溶于乙醇。药理作用与氯丙酸相似，具有消炎、镇痛、解热作用，消炎解热作用比氨基比林、氯丙酸、阿司匹林、保泰松强，镇痛作用较差，不良反应小。临床主要用于治疗风湿性关节炎和类风湿性关节炎，对后者效果较差，偶见的胃肠道不良反应包括胃部不适、腹泻、皮疹、蛋白尿、血尿、浮肿等反应，哮喘患畜慎用。
方法一:由间氨基三氟甲苯与邻氯苯甲酸缩合而得。
氟灭酸价格(试剂级):更新日期产品编号产品名称包装价格 2011/04/16 T2354 N-(3-三氟甲基苯基)邻氨基苯甲酸 N-(3-Trifluoromethylphenyl)anthranilic Acid 500G 3830元 2011/04/16 T2354 N-(3-三氟甲基苯基)邻氨基苯甲酸 N-(3-Trifluoromethylphenyl)anthranilic Acid 25G 446元 2010/06/21 165920500 氟灭酸 Flufenamic acid 97% 50 GR 707元
氟灭酸价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 T2354 N-(3-三氟甲基苯基)邻氨基苯甲酸 N-(3-Trifluoromethylphenyl)anthranilic Acid 500G 2470元 2014/06/02 T2354 N-(3-三氟甲基苯基)邻氨基苯甲酸 N-(3-Trifluoromethylphenyl)anthranilic Acid 25G 288元 2010/06/21 165920500 氟灭酸 Flufenamic acid 97% 50 GR 707元
Acros Organics:氟芬那酸 Flufenamic acid, 97%(530-78-9)
MSDS 信息:Flufenamic acid(530-78-9).msds
用途一:为非甾体抗炎药中间体
TCI Shanghai:N-(3-三氟甲基苯基)邻氨基苯甲酸 N-(3-Trifluoromethylphenyl)anthranilic Acid,>;98.0%(LC)(T)(530-78-9)
用途二:该品为消炎镇痛药。
下游产品:2-三氟甲基吩噻嗪
Sigma Aldrich:530-78-9(sigmaaldrich)
MOL 文件:530-78-9.mol