CAS 62-75-9 MFCD00002053-N,N-dimethylnitrous amide N,N-二甲基亚硝酰胺 TAO{mole}

N,N-dimethylnitrous amide N,N-二甲基亚硝酰胺

CAS 62-75-9 MFCD00002053

化学结构图

SMILES: CN(C)N=O

化学属性

Mol. Formula	C2H6N2O
Mol. Weight	74.08
Refractive index	1.4330 to 1.4370
Boiling Point	153 °C/774 mmHg(lit.)
Density	1.01 g/mL(lit.)
Vapor Pressure	5 mmHg ( 20 °C)
Flash Point	142 °F
Solubility	溶于水、乙醇、乙醚等。

别名和识别编码

Chemical Name	N,N-dimethylnitrous amide
CAS Number	62-75-9
Synonym	Dimethylnitrosamine {LY} Dimethylnitrosamine Dimethylnitrosoamine Methamine, N-methyl-N-nitroso- Methanamine, N-methyl-N-nitroso- Methanamine,N-methyl-N-nitroso- N,N-Dimethylnitrosamine N-Methyl-N-nitrosomethanamine N-NITROSODIMETHYLAMINE N-Nitroso-N,N-dimethylamine N-Nitrosodi-N-methylamine N-Nitrosodimethyl amine N-Nitrosodimethyl-amine N-Nitrosodimethylamine N-dimethylnitrosoamine N-methyl-N-nitroso-Methanamine N-二甲基亚硝胺 N-亚硝基二甲胺 N-亞硝二甲胺 N-甲基-N-亚硝基甲胺 {} {LY} Dimethylnitrosamine {} {} {LY} Dimethylnitrosamine {} {} {} {} {} {} {LY} Dimethylnitrosamine {} {} {} {} {LY} Dimethylnitrosamine {} {} {} {} {} {LY} Dimethylnitrosamine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Dimethylnitrosamine {} {} {} {} {} {
PubChem Substance ID	6124
EC Number	200-549-8
MDL Number	MFCD00002053
Chemical Name Translation	N,N-二甲基亚硝酰胺
Merck Number	6637
Wiswesser Line Notation	ONN1&1
Beilstein Registry Number	4,84
Reaxys-RN	1738979
LabNetwork Molecule ID	LN01301113
InChI	InChI=1S/C2H6N2O/c1-4(2)3-5/h1-2H3
Canonical SMILES	CN(N=O)C

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分类

Aliphatics, Alpha Sort, Alphabetic, Amines, Analytical Standards, Analytical/Chromatography, Applications, Chemical Class, Chromatography, EPA, EPA TO Methods, Environmental Standards, Food & Beverage Analysis, Method Specific, N, N-O, NA - NI, Nitrosamines, Processing/Packaging Contaminants, TO-7: N-Nitrosodimethylamine By Capillary GC-MS, Volatiles/ Semivolatiles
{uni_hamburg} no charge; organic nitrosamine; 1fragment

产品应用

A highly toxic semi-volatile organic compound and a suspected human carcinogen. It induces liver tumors in rats after chronic exposure to low doses.

安全信息

GHS Symbol

WGK Germany3

Hazard Codes T T+,N,T,F

Hazard statements

H227 Combustible liquid 可燃液体
H301 Toxic if swallowed 吞食有毒
H330 Fatal if inhaled 吸入致命
H350 May cause cancer 可能致癌
H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSIQ0525000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310+P330
P304+P340+P310
P305+P351+P338+P337+P313
P308+P311
P332 IF SKIN irritation occurs: 如果发生皮肤刺激：
P332+P313
P370+P378
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Packing GroupIII

Hazard Class6.1

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

UN Number 3382 UN 3382 6.1/PG 1

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Risk Statements

R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R11 Highly flammable 非常易燃
R45 May cause cancer 可能致癌
R48/25
R51/53
R26 Very toxic by inhalation 吸入极毒
R25 Toxic if swallowed 吞咽有毒

Warnings 危化品目录(2015) 危险化学品

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 13 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   46,985,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 mg/kg
                          female 15-21 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   IARCCD IARC Scientific Publications.  (Geneva, Switzerland)  No.1-26,
   1971-78.  For publisher information, see IAPUDO.  Volume(issue)/page/year:
   4,1,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   30,2796,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 49 mg/kg/71W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   IARCCD IARC Scientific Publications.  (Geneva, Switzerland)  No.1-26,
   1971-78.  For publisher information, see

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 57 ppm/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - somnolence (general depressed activity)
   Blood - hemorrhage
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 12,617,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Liver - jaundice (or hyperbilirubinemia) hepatocellular
   Liver - other changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   AVSCA7 Acta Veterinaria Scandinavica.  (Danske Dyrlargeforening, Alhambravej
   15, DK-1826 Copenhagen V, Denmark)  V.1-    1959- Volume(issue)/page/year:
   22,501,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSER

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   BJIMAG British Journal of Industrial Medicine.  (British Medical Journal,
   Box 560B, Kennebunkport, ME 04046)  V.1-    1944-  Volume(issue)/page/year:
   11,167,1954

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 20 mg/kg/2.5Y
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from small intestine
   Gastrointestin

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 30 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 124,299,1983

TYPE OF TEST            : Morpholo

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 100 mg/L
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   28,215,1973

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Neurospora crassa
DOSE/DURATION           : 90 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 31,195,1975

TYPE OF TEST            : Gene co

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 1 ug/L
REFERENCE :
   BANRDU Banbury Report.  (Cold Spring Harbor Laboratory, POB 100, Cold Spring
   Harbor, NY 11724) V.1-    1979-  Volume(issue)/page/year: 12,3,1982

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   RPZHAW Roczniki Panstwowego Zakladu Higieny.  (Ars Polona, POB 1001, 00-068
   Warsaw 1, Poland) V.1-    1950-  Volume(issue)/page/year: 33,215,1982

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Subcutaneous
TEST SY

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   21,453,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 mg/kg
SEX/DURATION            : female 18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 24,251,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1940 ug/kg
SEX/DURATION            : female 75 day(s) pre-mating
                          female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 19,311,1978

其他信息

外观性质:黄色液体。
急性毒性:口服-大鼠 LD50: 37 毫克/公斤; 腹腔-小鼠 LD50: 19 毫克/公斤
可燃性危险特性:遇明火可燃;高热分解有毒氮氧化物烟雾
灭火剂:二氧化碳、泡沫、砂土、干粉、抗溶性泡沫。
用途一:有机合成中间体。用于火箭燃料、抗氧剂等制造。
方法一:将245g盐酸二甲胺和盐酸搅拌加热至70-75℃，加入235g亚硝酸钠在150ml水中的浆状液，同时添加盐酸使反应物恰呈酸性。加毕，加热2h，然后蒸馏至近干，加水再蒸干，将馏出物合并用300g碳酸钾使之饱和，取上层减压分馏，得近200gN-亚硝基二甲胺，收率近90%。
蒸气压:5 mm Hg ( 20 °C)
上游原料:盐酸二甲胺
储运特性:库房通风低温干燥; 与氧化剂、食品添加剂分开存放
MOL 文件:62-75-9.mol
Sigma Aldrich:62-75-9(sigmaaldrich)
MSDS 信息:二甲基亚硝基代胺(62-75-9).msds
毒性分级:剧毒
图谱信息:N-亚硝基二甲胺(62-75-9)质谱(MS)
类别:有毒物品