• 原料直供
• 试剂商城
• 直接询价

分类

• {uni_hamburg} no charge; cyanide; 1fragment
• Building Blocks, C1 to C5, Chemical Synthesis, Cyanides/Nitriles, Nitrogen Compounds, Organic Building Blocks
• {SNA} Building Blocks, C1 to C5, Chemical Synthesis, Cyanides/Nitriles, Nitrogen Compounds, Organic Building Blocks

产品应用

• 氰基化试剂

相关文献及参考

• {ALF
• Tertiary alkyl halides normally undergo elimination when treated with alkali cyanides, but can be converted to the corresponding nitriles by reaction with TM
• Reacts with epoxides in the presence of ZnI2 to give trans-ɑ-siloxy isocyanides, which can be readily hydrolyzed to the hydroxy isocyanides: J. Am. Chem. Soc., 104, 5849 (1982); Org. Synth. Coll., 7, 294 (1990). In the presence of Ag salts (AgClO4, AgBF4 or AgOTf), alkenes can be converted to isocyanides in Markovnikov fashion: Synlett, 288 (1999).
• For a brief survey of uses of this reagent in synthesis, see: Synlett, 1625 (2007).
• Beilstein: 4,IV,3893
• The ZnI2-catalyzed procedure allows cyanohydrins of unreactive ketones to be prepared in good yield, avoiding the unfavourable equilibria often encountered with the classical alkali cyanide method. For details and list of examples, see: Org. Synth. Coll., 7, 20 (1990). Other catalysts including Et3N or Bu3P are also effective: Chem. Lett., 537, 541 (1991). For catalysis by Methyl­ triphenyl­phosphonium iodide, A15644, see: Tetrahedron Lett., 44, 6157 (2003). In the absence of a catalyst, aldehydes have been found to give good yields of the TMS cyanohydrin, but reaction with ketones is very slow: J. Chem. Soc., Perkin 1, 2383 (1995). For use of Tetracyanoethyl­ene, A13945, as a c-acid catalyst for both aldehydes and ketones, see: J. Chem. Soc., Perkin 1, 2155 (1995). Under the same conditions, dimethyl acetals
• The ZnI2-catalyzed procedure allows cyanohydrins of unreactive ketones to be prepared in good yield, avoiding the unfavourable equilibria often encountered with the classical alkali cyanide method. For details and list of examples, see: Org. Synth. Coll., 7, 20
• Tertiary alkyl halides normally undergo elimination when treated with alkali cyanides, but can be converted to the corresponding nitriles by reaction with TMSCN in the presence of SnCl4: Angew. Chem. Int. Ed., 20, 1017 (1981).

安全信息

GHS Symbol

其他信息

• TCI Shanghai:三甲基氰硅烷 Trimethylsilyl Cyanide,>;96.0%(GC)(7677-24-9)
• 存储注意事项:湿度敏感;氮气保护
• 海关编码:29310095
• Alfa Aesar:氰化三甲基硅烷,97% Trimethylsilyl cyanide, 97%(7677-24-9)
• Hazard Note:Highly Flammable/Toxic
• F:10-21
• 和水反应。
• 用途一:氰基化试剂
• Acros Organics:三甲基氰硅烷 禁运 Trimethylsilyl cyanide, 98%(7677-24-9)
• 图谱信息:三甲基氰硅烷(7677-24-9)红外图谱(IR1) 三甲基氰硅烷(7677-24-9)核磁图( 13 CNMR) 三甲基氰硅烷(7677-24-9)核磁图( 1 HNMR)
• 下游产品:4-甲基-2-羧酸吡啶 --> 2-氰基吡啶-4-醛 --> 2-氰基吡啶-4-羧酸乙酯 --> 4-羟甲基吡啶-2-腈 --> 8-羟基喹啉-2-羧酸 --> 三苯氧基苯甲醛 --> 二乙胺基三氟化硫 --> 2-氯-3-氰基吡嗪 --> 8-羟基喹啉-2-甲腈 --> 3-氯-2-氰基吡啶 --> 4-氰基吡啶-4-羧酸
• 上游原料:吡啶 --> 氰化钾 --> 碘化钾 --> 碘化钠 --> 三甲基氯硅烷 --> N-甲基吡咯烷酮 --> LEDA HPLC乙腈
• MOL 文件:7677-24-9.mol
• MSDS 信息:Cyanotrimethylsilane(7677-24-9).msds
• 检测方法:GC,NMR
• 敏感性:Moisture Sensitive
• Sigma Aldrich:7677-24-9(sigmaaldrich)
• 三甲基氰硅烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010061 氰基三甲基硅烷 5g 140元 2011/04/16 T0990 三甲基氰硅烷 Trimethylsilyl Cyanide 100ML 2620元 2011/04/16 T0990 三甲基氰硅烷 Trimethylsilyl Cyanide 25ML 880元
• TSCA:Yes