• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Alphabetical, Amino Acid Analysis, Amino Acids, Analytical Reagents, Analytical/Chromatography, Application Spe
• {SNA} Carbonyl Chlorides, Derivatization Reagents, Derivatization Reagents HPLC, Fluorescence, Fluorescent Labels, Other Fluorescent Labels, UV-VIS, 分析/色谱, 分析试剂, 生化试剂, 荧光探针，标记，粒子和染色剂
• {SNA} Amine Protection, Chemical Biology, Chemical Synthesis, Others, Peptide Chemistry, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents
• {SNA} Alphabetical,

产品应用

• 在氨基酸 HPLC 分析中，用于衍生化氨基酸；在固相肽合成中用于制备 N-Fmoc 氨基酸。
• 氨基保护试剂，最近用于合成二环脯氨酸类似物。
• 用于 HLPC 分析的氨基酸衍生化试剂。N-保护试剂，用于肽和寡聚核苷酸的合成。

相关文献及参考

• Reagent for the protection of amino groups in peptide synthesis (see Appendix 6) as their 9-fluorenylmethoxycarbonyl (Fmoc) derivatives: J. Org. Chem., 37, 3404 (1972); J. Am. Chem. Soc., 96, 4987 (1974); 99, 7363 (1977). Review: Acc. Chem. Res., 20, 401 (1987). They are particularly applicable in solid-phase peptide synthesis. The stability of Fmoc-protected amino acids to acidic conditions permits their conversion in many cases to the acid chlorides as active intermediates for peptide coupling, resistant to racemization, in contrast to other protected amino acid chlorides. For a review of peptide synthesis via amino acid halides, see: Acc. Chem. Res., 29, 268 (1996).
• Merck: 14,10354
• In the presence of triethylamine, reacts with Pentafluorophenol, A15574, to give the PFP carbonate, a useful active ester for the preparation of Fmoc-amino acids. Moreover, the active PFP ester of the protected amino acid can be obtained by in situ DCC coupling with the liberated PFP: Synthesis, 303 (1986).
• Cleavage of the Fmoc group occurs under mildly basic conditi
• Limited use has also been made in the protection of alcohols as 9-fluorenylmethyl carbonates, rapidly cleaved by triethylamine: J. Chem. Soc., Chem. Commun., 672 (1982).
• TBAF in DMF; rapid reaction at room temperature: Tetrahedron Lett., 28, 6617 (1987). For both the deblocking of Fmoc-protected amino acids and for the removal of excess reagent during the protection step, 4-(Aminomethyl)­piperidine, L11577, has been recommended: J. Org. Chem., 51, 3732 (1986); 55, 721 (1990), particularly in conjunction with Fmoc-protected acid chlorides as the active species. Even better results have been obtained with Tris(2-aminoethyl)­amine, B21789, in this type of chemistry: J. Org. Chem., 55, 1673 (1990).
• Ethanolamine: J. Am. Chem. Soc., 92, 5748 (1970); J. Org. Chem., 37, 3404 (1972). Piperidine: J. Org. Chem., 52, 1197 (1987); applicable to solid-phase peptide synthesis.

安全信息

GHS Symbol

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 170,23,1986

其他信息

• 室温下长期放置会缓慢分解。易吸潮，水中分解。