CAS 53-96-3 MFCD00001116-2-Acetamidofluorene 2-乙酰氨基芴 TAO{mole}

2-Acetamidofluorene 2-乙酰氨基芴

CAS 53-96-3 MFCD00001116

化学结构图

SMILES: CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2

化学属性

Mol. Formula	C15H13NO
Mol. Weight	223.27
Melting Point	192-196 °C
Density	1.23
Boiling Point	364.56 °C at 760 mmHg

别名和识别编码

Chemical Name	2-Acetamidofluorene
Synonym	2-Acetamidofluorene {LY} 2-Acetamidofluorene {} {LY} 2-Acetamidofluorene {} {} {LY} 2-Acetamidofluorene {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Acetamidofluorene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Acetamidofluore
MDL Number	MFCD00001116
CAS Number	53-96-3
Beilstein Registry Number	12(3)3287
EC Number	200-188-6
PubChem Substance ID	5897
Reaxys-RN	2807677
Merck Number	4157
Chemical Name Translation	2-乙酰氨基芴
Wiswesser Line Notation	L B656 HHJ EMV1
LabNetwork Molecule ID	LN00195300
InChI	InChI=1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)
Canonical SMILES	CC(NC1=CC2=C(C=C1)C(C=CC=C3)=C3C2)=O

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

遗传毒性致癌物，用于使小鼠的肝脏致癌，当被肝中的细胞色素CYP1A2 N-氢氧化后，2-AAF嵌入DNA，从而导致肝脏和膀胱肿瘤。

安全信息

GHS Symbol

RTECSAB9450000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P301+P312+P330
P301+P317
P308+P313
P318
P330 Rinse mouth. 漱口
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害
H350 May cause cancer 可能致癌

WGK Germany3

Signal word

Personal Protective Equipment Eyeshields, Gloves, type P2 (EN 143) respirator cartridges Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Hazard Codes T

Risk Statements

R45 May cause cancer 可能致癌
R22 Harmful if swallowed 吞咽有害

Packing GroupIII

Hazard Class6.1(b)

UN Number UN 3077 9/PG 3

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
                          female 15 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - transplacental tumorigenesis
   Liver - tumors
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 20,293,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 192 mg/kg/4W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   32,1554,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 260 mg/kg/71W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - adrenal cortex tumors
   Skin and Appendages - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   10,1201,1950

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 14 gm/kg/56W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
   Rep

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 810 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - altered sleep time (including change in righting reflex)
   Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 143,1117,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 470 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 223,361,1989

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   56,151,1985

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 2800 nmol/L
REFERENCE :
   CNJGA8 Canadian Journal of Genetics and Cytology.  (National Research
   Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6,
   Canada)  V.1-    1959-  Volume(issue)/page/year: 24,771,1982

TYPE OF TEST            : DNA repair
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 500 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 290,175,1993

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 200 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,224,1981

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 157,181,1985

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 75 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 223,361,1989

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 300 umol/L/2H
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Acad

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 100 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   KAIZAN Kaibogaku Zasshi.  Journal of Anatomy.  (Nippon Kaibo Gakkai, c/o
   Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan)  V.1- 1928-
    Volume(issue)/page/year: 37,239,1962

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   IARCCD IARC Scientific Publications.  (Geneva, Switzerland)  No.1-26,
   1971-78.  For publisher information, see IAPUDO.  Volume(issue)/page/year:
   4,112,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 100 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects o

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 625 mg/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 124,235,1983

其他信息

2-乙酰氨基氟价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 A0076 2-乙酰氨基芴 2-Acetamidofluorene 5G 803元 2014/06/02 A0076 2-乙酰氨基芴 2-Acetamidofluorene 25G 2340元 2010/06/21 102300050 2-乙酰氨基氟 2-Acetamidofluorene 95% 5 GR 1363元
用途一:遗传毒性致癌物，用于使小鼠的肝脏致癌，当被肝中的细胞色素CYP1A2 N-氢氧化后，2-AAF嵌入DNA，从而导致肝脏和膀胱肿瘤。
Acros Organics:2-乙酰氨基芴 2-Acetamidofluorene, 95%(53-96-3)
Sigma Aldrich:53-96-3(sigmaaldrich)
color:off-white to tan
MOL 文件:53-96-3.mol
图谱信息:2-乙酰氨基氟(53-96-3)红外图谱(IR1) 2-乙酰氨基氟(53-96-3)核磁图( 1 HNMR) 2-乙酰氨基氟(53-96-3)核磁图( 13 CNMR)
TCI Shanghai:2-乙酰氨基芴 2-Acetamidofluorene,>;98.0%(LC)(N)(53-96-3)