Phenacyl Chloride 苯甲酰甲基氯

CAS 532-27-4 MFCD00000933

化学结构图

532-27-4
SMILES: O=C(CCl)c1ccccc1

化学属性

Mol. FormulaC8H7ClO
Mol. Weight154.60
Density1.324
Flash Point118°(244°F)
TSCAYes
Boiling Point243-244°
Melting Point52-56°
Solubilityinsoluble. <0.1 g/100 mL at 19 °C
Refractive index1.5438

别名和识别编码

Chemical NamePhenacyl Chloride
MDL NumberMFCD00000933
Synonym 氯代乙酰苯 Α-氯代苯乙酮 2-CHLORO-1-PHENYLETHANONE PHENACYL CHLORIDE 2-氯乙酰苯 氯苯乙酮 A-CHLOROACETOPHENONE Ethanone, 2-chloro-1-phenyl- CN Chemical mace 1-Chloroacetophenone ω-氯代苯乙酮 Chloromethyl phenyl ketone 2-chloro-1-phenyl-ethanon α-氯代苯乙酮 Chloromethyl phenylketone 2-Chloro-1-oxoethyl)benzene "teargas"[qr] alpha-氯乙酰苯 BETA-CHLOROACETOPHENONE ALPHA-氯代丙酰氯 2-chloro-acetophenon ALPHA-氯苯乙酮 PHENACYLCHLORID Α-氯苯乙酮 Acetophenone, 2-chloro- 2-chloro-1-phenylethanone[qr] 苯基氯甲基甲酮 Phenacyl chloride NCI-C55107 Α-氯乙酰苯 氯化苯乙酮 2-Chloro-1-phenylethanone ALPHA-CHLOROACETOPHENONE OMEGA-CHLOROACETOPHENONE W-CHLOROACETOPHENONE omega-Chloroacetophenone alpha-氯代苯乙酮 1-chloroacetophenone[qr] 2-Chloroacetophenone Phenylchloromethylketone 2-氯苯乙酮,99% alpha-Chloroacetophenone 2-CHLOROACETOPHENONE a-phenacyl chloride 苯酰甲基氯 2-氯苯乙酮 氯乙酰苯 Mace (lacrimator) acetophenone,2-chloro-
EC Number208-531-1
CAS Number532-27-4
Merck Number14,2115
Beilstein Registry Number0507950
PubChem Substance ID24892454
Alfabeta NameCHLOROACETOPHENONE 2-
Chemical Name Translation苯甲酰甲基氯
Wiswesser Line NotationG1VR
LabNetwork Molecule IDLN00182275
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分类

  • {SNA} Bioactive Small Molecules, Building Blocks, C-CH, C7 to C8, Carbonyl Compounds, Cell Biology, Chemical Synthesis, Ketones, Organic Building Blocks

安全信息

RTECSAM6300000
Safety Statements
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S22 Do not breathe dust 不要吸入粉尘;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
Packing GroupII
UN Number UN1697 UN 1693 6.1/PG 2
Risk Statements
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R25 Toxic if swallowed 吞咽有毒
  • R42/43
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
Storage condition Moisture Sensitive
GHS Symbol
WGK Germany3
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H300 Fatal if swallowed 吞食致命
  • H318 Causes serious eye damage 严重伤害眼睛
  • H311+H331
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P301+P310
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
Signal word Danger
Warnings 危化品目录(2015) IRRITANT
Hazard Codes T
Hazard Class6.1
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2 mg/m3/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
   Skin and Appendages - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-379,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2400 mg/kg/27W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   7,482,1953

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory stimulation
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   40,75,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 139 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD837-111

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 118 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Lungs, Thorax, or Respiration - other changes
   Skin and Appendages - hair
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   40,75,1978

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 93 mg/m3/3M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Sense Organs and Special Senses (Eye) - conjunctive irritation
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   AIHAAP American Industrial H

TYPE OF TEST            : LD50 - Lethal d

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 3 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-379,1990

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 10 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,59,1996

Restrict 危险品

其他信息

  • 职业标准:TWA 0.3 毫克/ 立方米; STEL 0.9 毫克/立方米
  • 下游产品:杀虫畏 --> 4-苯基-5-氯-1,2,3-噻重氮 --> DL-扁桃酸
  • 上游原料:氧氯化硫 --> 丙酮 --> 二硫化碳 --> 氯苯 --> 氯乙酰氯 --> 稀盐酸
  • Alfa Aesar:2-氯苯乙酮,99% 2-Chloroacetophenone, 98%(532-27-4)
  • 方法一:1.由苯乙酮氯化而得:将苯乙酮加入反应锅,通入氯气,在60-70℃下反应,通氯后升温至80℃,减压蒸去低沸物。冷至5℃以下,静置48h,析出结晶。过滤得氯代苯乙酮。收率70%。2.由氯乙酰氯与苯反应:将二氯亚砜加入氯乙酸中,搅拌回流3h,蒸馏出粗品,将其与二硫化碳混合,慢慢加入苯、无水三氯化铝和二硫化碳的混合液中,温度不超过50℃,一般保持在30℃以下,加完后加热回流3h,静置,倒入冰水及稀盐酸溶液,过滤吹干,用稀乙醇重结晶两次,所得产物减压蒸馏即得成品。
  • MOL 文件:532-27-4.mol
  • 用途二:该品用于有机合成,在医药上用于合成盐酸四咪唑等。
  • MSDS 信息:2-氯乙酰苯(532-27-4).msds
  • 用途一:用于制药及用于有机合成
  • 图谱信息:alpha-氯乙酰苯(532-27-4)红外图谱(IR2) alpha-氯乙酰苯(532-27-4)质谱(MS) alpha-氯乙酰苯(532-27-4)核磁图( 13 CNMR) alpha-氯乙酰苯(532-27-4)红外图谱(IR1)
  • 外观性质:白色晶体。
  • 急性毒性:口服- 大鼠 LD50: 50 毫克/ 公斤; 口服- 小鼠 LD50: 139 毫克/ 公斤
  • 刺激数据:皮肤- 兔子 5 毫克/ 24小时 轻度; 眼- 兔子 3 毫克 重度
  • 可燃性危险特性:明火可燃; 高热分解有毒氯化物气体; 与水反应产生有毒及腐蚀性气体
  • Sigma Aldrich:532-27-4(sigmaaldrich)
  • 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂分开存放
  • 灭火剂:干粉、泡沫、二氧化碳、砂土
  • F:9-19
  • 敏感性:Moisture Sensitive
  • 毒性分级:高毒
  • 类别:有毒物品

系列性分类


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