Phenacyl Chloride 苯甲酰甲基氯
CAS 532-27-4 MFCD00000933
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Bioactive Small Molecules, Building Blocks, C-CH, C7 to C8, Carbonyl Compounds, Cell Biology, Chemical Synthesis, Ketones, Organic Building Blocks
安全信息
- S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S20 When using do not eat or drink 使用时,不得进食,饮水;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- S22 Do not breathe dust 不要吸入粉尘;
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R25 Toxic if swallowed 吞咽有毒
- R42/43
- R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H300 Fatal if swallowed 吞食致命
- H318 Causes serious eye damage 严重伤害眼睛
- H311+H331
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P301+P310
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 mg/m3/6H/2Y-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - tumors Skin and Appendages - tumors REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-379,1990
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2400 mg/kg/27W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 7,482,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Kidney, Ureter, Bladder - other changes REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,75,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 139 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD837-111
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 118 mg/kg TOXIC EFFECTS : Behavioral - coma Lungs, Thorax, or Respiration - other changes Skin and Appendages - hair REFERENCE : ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 40,75,1978
TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Human DOSE/DURATION : 93 mg/m3/3M TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - dyspnea REFERENCE : AIHAAP American Industrial H
TYPE OF TEST : LD50 - Lethal d
TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Ovary DOSE/DURATION : 3 mg/L REFERENCE : NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-379,1990
TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - rat Liver DOSE/DURATION : 10 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 368,59,1996
其他信息
- 职业标准:TWA 0.3 毫克/ 立方米; STEL 0.9 毫克/立方米
- 下游产品:杀虫畏 --> 4-苯基-5-氯-1,2,3-噻重氮 --> DL-扁桃酸
- 上游原料:氧氯化硫 --> 丙酮 --> 二硫化碳 --> 氯苯 --> 氯乙酰氯 --> 稀盐酸
- Alfa Aesar:2-氯苯乙酮,99% 2-Chloroacetophenone, 98%(532-27-4)
- 方法一:1.由苯乙酮氯化而得:将苯乙酮加入反应锅,通入氯气,在60-70℃下反应,通氯后升温至80℃,减压蒸去低沸物。冷至5℃以下,静置48h,析出结晶。过滤得氯代苯乙酮。收率70%。2.由氯乙酰氯与苯反应:将二氯亚砜加入氯乙酸中,搅拌回流3h,蒸馏出粗品,将其与二硫化碳混合,慢慢加入苯、无水三氯化铝和二硫化碳的混合液中,温度不超过50℃,一般保持在30℃以下,加完后加热回流3h,静置,倒入冰水及稀盐酸溶液,过滤吹干,用稀乙醇重结晶两次,所得产物减压蒸馏即得成品。
- MOL 文件:532-27-4.mol
- 用途二:该品用于有机合成,在医药上用于合成盐酸四咪唑等。
- MSDS 信息:2-氯乙酰苯(532-27-4).msds
- 用途一:用于制药及用于有机合成
- 图谱信息:alpha-氯乙酰苯(532-27-4)红外图谱(IR2) alpha-氯乙酰苯(532-27-4)质谱(MS) alpha-氯乙酰苯(532-27-4)核磁图( 13 CNMR) alpha-氯乙酰苯(532-27-4)红外图谱(IR1)
- 外观性质:白色晶体。
- 急性毒性:口服- 大鼠 LD50: 50 毫克/ 公斤; 口服- 小鼠 LD50: 139 毫克/ 公斤
- 刺激数据:皮肤- 兔子 5 毫克/ 24小时 轻度; 眼- 兔子 3 毫克 重度
- 可燃性危险特性:明火可燃; 高热分解有毒氯化物气体; 与水反应产生有毒及腐蚀性气体
- Sigma Aldrich:532-27-4(sigmaaldrich)
- 储运特性:库房通风低温干燥; 与氧化剂、食品添加剂分开存放
- 灭火剂:干粉、泡沫、二氧化碳、砂土
- F:9-19
- 敏感性:Moisture Sensitive
- 毒性分级:高毒
- 类别:有毒物品