CAS 72-43-5 MFCD00000803-Methoxychlor 甲氧滴滴涕,甲氧氯 TAO{mole}

Methoxychlor 甲氧滴滴涕,甲氧氯

CAS 72-43-5 MFCD00000803

化学结构图

SMILES: COc1ccc(C(c2ccc(OC)cc2)C(Cl)(Cl)Cl)cc1

化学属性

Mol. Formula	C16H15Cl3O2
Mol. Weight	345.65
Melting Point	86-88 °C(lit.)
TSCA	No
Flash Point	11 °C
Appearance	crystalline
Solubility	不溶于水，易溶于芳烃。
Density	0.7915

别名和识别编码

Chemical Name	Methoxychlor solution
MDL Number	MFCD00000803
CAS Number	72-43-5
Synonym	,p-Methoxychlor 1,1'-(2,2,2-trichloroethylidene)bis(4-methoxybenzene) 1,1,1 1,1,1-TRICHLORO-2,2-BIS (4-METHOXYPHENYL) ETHANE 1,1,1-TRICHLORO-2,2-BIS(P-METHOXYPHENYL)-ETHANE 1,1,1-Tri 1,1,1-Trichlor-2,2-bis(4-methoxy-phenyl)-aethan 1,1,1-Trichloro-2,2-bis(4-methoxyphenyl)ethane 1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane 1,1,1-Trichloro-2,2-bis(p-anisyl)ethane 1,1,1-Trichloro-2,2-bis(p-methoxyphenyl)ethane 1,1,1-三 1,1,1-三氯-2,2-双对甲氧苯基乙烷 1,1-Bis(p-methoxyphenyl)-2,2,2-trichloroethane 2,2,2-Trichloro-1,1-bis(4-methoxyphenyl)ethane 2,2-Bis(4-meth 2,2-Bis(p-methoxyphenyl)-1,1,1-trichloroethane 2,2-Di-(p-methoxyphenyl) 2,2-Di-p-anisyl-1,1,1-trichloroethane 2,2-双(对甲氧苯基)-1,1,1-三氯乙
PubChem Substance ID	4115
Beilstein Registry Number	2057367
EC Number	200-779-9
Merck Number	14,5990
Chemical Name Translation	甲氧滴滴涕,甲氧氯
Wiswesser Line Notation	GXGGYR DO1&R DO1
LabNetwork Molecule ID	LN01308083
InChI	InChI=1S/C16H15Cl3O2/c1-20-13-7-3-11(4-8-13)15(16(17,18)19)12-5-9-14(21-2)10-6-12/h3-10,15H,1-2H3

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产品应用

甲氧滴涕用于87种农作物的害虫防治，为触杀和胃毒性广谱杀虫剂，主要用于防治食芽象甲，杨尺蛾等林木、枣树害虫。DMDT具有滴滴涕的优点而无滴滴涕的缺点。他对人畜的毒性很低。
甲氧滴涕作为主要杀虫剂品种之一，经过多年的应用，在发展低毒农作物的今天仍占有不可替代的地位。

安全信息

RTECSKJ3675000

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P310
P301+P312
P301+P317
P302+P352
P304+P312
P304+P340
P308+P313
P308+P316
P309+P311
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P318
P319
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H302+H312+H332
H311 Toxic in contact with skin 皮肤接触中毒
H312 Harmful in contact with skin 皮肤接触有害
H331 Toxic if inhaled 吸入中毒
H332 Harmful if inhaled 吸入有害
H351 Suspected of causing cancer 怀疑致癌
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H370 Causes damage to organs 导致器官损伤
H371 May cause damage to organs 可能导致器官损伤
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

WGK Germany3

Signal word Danger Warning

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)

Safety Statements

S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S7 Keep container tightly closed 保存在严格密闭容器中；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐：立即求医并出示该容器或标签；
S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；

Hazard Codes F,T Xn,T,F,N Xn

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R50/53
R11 Highly flammable 非常易燃
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
R38 Irritating to skin 刺激皮肤

Packing GroupIII

UN Number UN3077 UN 2811 6.1/PG 3

Storage condition APPROX 4°C 储存温度2-8℃

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 41 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - multiple effects
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   11,88,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 383 gm/kg/3Y-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Liver - tumors
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of

TYPE OF TEST            :

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 72800 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 36,205,1980

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 87360 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   EVHPAZ EHP, Environmental Health Perspectives.  (U.S. Government Printing
   Office, Supt of Documents, Washington, DC 20402)  No.1-    1972-
   Volume(issue)/page/year: 36,205,1980

TYPE OF TEST            : TD - Toxic dose (other than lowest)
R

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   WRPCA2 World Review of Pest Control.  (London, UK)  V.1-10, 1962-71.
   Discontinued.  Volume(issue)/page/year: 3,28,1964

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
   Health Service, Communicable Disease Center, Atlanta, GA, 1956
   Volume(issue)/page/year: -,1,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent k

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SPEADM Special Publication of the Entomological Society of America.  (4603
   Calvert Rd., College Park, MD 20740)  Volume(issue)/page/year: 78-1,16,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 510 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 58(1),44,1993

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 2 mg/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 67,1303,1981

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   58,152,1986

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 28 gm/kg/10W (Continuous)
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 176,187,1984

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 356,85,1996

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 6 mg/kg/50D (Intermittent)
REFERENCE :
   FOMOAJ Folia Morphologica (Warsaw).  (Panstwowy Zaklad Wydawnictw
   Lekarskich, ul. Dluga 38-40, 00 238 Warsaw, Poland)  V.1-    1929-
   Volume(issue)/page/year: 35,361,1976

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   EMMUEG Envi

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4250 mg/kg
SEX/DURATION            : female 42 day(s) pre-mating  - 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Effects on Newborn - physical
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   JAFCAU Journal of Agricultural and Food Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC
   20037)  V.1-    1953-  Volume(issue)/page/year: 22,969,1974

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - parturition
REFERENCE :
   REPTED Reproductive Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1987-  Volume(issue)/page/year:
   6,431,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2100 mg/kg
SEX/DURATION            : female 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - oogenesis
REFERENCE :
   AHEMA5 Anatomia, Histologia, Embryologia.  (Paul Parey Scientific Pub., 35
   W. 38th St., Suite 3W, New York, NY 10018)  V.2-    1973-
   Volume(issue)/page/year: 9,89,1980

其他信息

储运特性:库房通风低温干燥; 与食品原料分开储运
图谱信息:甲氧滴滴涕,甲氧氯(72-43-5)红外图谱(IR2) 甲氧滴滴涕,甲氧氯(72-43-5)核磁图( 1 HNMR) 甲氧滴滴涕,甲氧氯(72-43-5)核磁图( 13 CNMR) 甲氧滴滴涕,甲氧氯(72-43-5)质谱(MS) 甲氧滴滴涕,甲氧氯(72-43-5)红外图谱(IR1)
类别:农药
Sigma Aldrich:72-43-5(sigmaaldrich)
毒性分级:中毒
color:yellow
可燃性危险特性:燃烧产生有毒氯化物气体
MOL 文件:72-43-5.mol
MSDS 信息:甲氧滴滴涕(72-43-5).msds
TCI Shanghai:1,1-二（4-甲氧基苯基)-2,2,2-三氯乙烷 Methoxychlor,>;95.0%(GC)(72-43-5)
外观性质:无色或白色粉末结晶。
毒性:大鼠急性经口LD 50 >10000mg/kg（6000mg/kg)，大鼠急性经皮LD 50 >10000mg/kg。对兔皮肤和眼睛有轻度刺激作用。大鼠经口30d无作用剂量为500mg/kg，2年喂养试验无作用剂量为200mg/kg。狗1年喂养试验无作用剂量为300mg/kg。动物试验未见致畸、致癌、致突变作用。野鸭LD 50 >2000mg/kg，鹌鹑>5000mg/kg，野鸡>5000mg/kg。虹鳟鱼LC 50 为45μg/L（24h)，蜜蜂LD 50 为165.5μg/只。
职业标准:TLV-TWA 10 毫克/ 立方米; STEL 20 毫克/ 立方米
灭火剂:干粉、泡沫、砂土
上游原料:三氯化铝 --> 苯甲醚 --> 三氯乙醛
用途一:有机氯杀虫剂。具有触杀和胃毒作用，无内吸作用，杀虫谱广，对人畜毒性较低，在有机体内无累积作用，易被多功能氧化酶分解，而转为水溶性无毒排泄物。可用于大田作物、果树、蔬菜等作物，防治玉米螟、造桥虫、豆甲、豌豆象、果树食心虫、苹果蠹蛾、日本金龟甲、小象虫、天幕毛虫、实蝇、叶蝉、蝽象、蔬菜叶跳甲、菜蛾、黄守瓜、种蝇等害虫，还可用于防治家畜体外寄生虫和卫生害虫。
杀虫剂单一组分标准液
急性毒性:口服- 大鼠 LD50: 1855 毫克/ 公斤; 口服- 小鼠 LD50: 510 毫克/ 公斤
方法一:在发烟硫酸或三氯化铝存在下，苯甲醚与三氯乙醛缩合制得甲氧滴滴涕。