CAS 627-63-4 MFCD00000733-Fumaryl Chloride 反丁烯二酰氯 TAO{mole}

Fumaryl Chloride 反丁烯二酰氯

CAS 627-63-4 MFCD00000733

化学结构图

SMILES: O=C(Cl)/C=C/C(=O)Cl

化学属性

Mol. Formula	C4H2Cl2O2
Mol. Weight	152.96
Density	1.415
Refractive index	1.4970 to 1.5010
Boiling Point	161-164
Flash Point	77°C(lit.)
TSCA	Yes
Melting Point	-2
Solubility	分解

别名和识别编码

Chemical Name	Fumaryl Chloride
Synonym	(2E)-2-Butendiyldichlorid (2E)-2-Butenedioyl dichloride (E)-1,4-Dioxo-2-butenyl dichloride (E)-1,4-Dioxo-2-butenyldichloride (E)-butenedioyl dichloride (E)-butenedioyldichloride (e)-2-butenedioyldichlorid 2-Butenedioyl dichloride 2-Butenedioyl dichloride, (2E)- 2-Butenedioyl dichloride, (E)- trans-2-Butenedioyl dichloride trans-Butendisäuredichlorid Chlorure de fumaryle Dichlorid kyseliny fumarove FUMAROYL DICHLORIDE FUMARYL CHLORIDE FUMARYL DICHLORIDE Fumaric acid chloride Fumaric acid dichloride Fumaric dichloride Fumaroyl chloride Fumaroyl dichloride Fumaroylchlorid Fumaroyldichlorid Fumarsäured
CAS Number	627-63-4
EC Number	211-005-4
Beilstein Registry Number	1721342
MDL Number	MFCD00000733
PubChem Substance ID	5325504
Chemical Name Translation	反丁烯二酰氯
Reaxys-RN	1721342
Wiswesser Line Notation	GV1U1VG
InChI	InChI=1S/C4H2Cl2O2/c5-3(7)1-2-4(6)8/h1-2H/b2-1+

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安全信息

Signal word Danger

GHS Symbol

WGK Germany3

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S8 Keep container dry 保持容器干燥；

Risk Statements

R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R34 Causes burns 会导致灼伤
R37 Irritating to respiratory system 刺激呼吸道

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P303+P361+P353
P304+P340
P305+P351+P338
P305+P351+P338+P310
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P370+P378
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H302+H312+H332
H302+H312
H227 Combustible liquid 可燃液体

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSLT2800000

Packing GroupII

UN Number 1780 UN 1780 8/PG 2

Storage condition Moisture Sensitive N/A N/A℃ No Data Available Refrigerator (+4°C)

Hazard Codes 8 C

Hazard Class8

Warnings 危化品目录(2015)

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1410 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   30,470,1969

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   30,470,1969

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1000 mg/m3/10M
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Musculoskeletal - other changes
REFERENCE :
   NDRC** National Defense Research Committee, Office of Scientific Research
   and Development, Progress Report.  Volume(issue)/page/year:
   NDCrc-132,MAY1942

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 810 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:
   30,470,1969

Restrict 危险品

其他信息

F:21
下游产品:反-1,2-二苯酰乙烯
用途一:用于有机合成。
图谱信息:反丁烯二酰氯(627-63-4)质谱(MS) 反丁烯二酰氯(627-63-4)核磁图( 1 HNMR) 反丁烯二酰氯(627-63-4)核磁图( 13 CNMR) 反丁烯二酰氯(627-63-4)红外图谱(IR1)
Acros Organics:富马酰氯 Fumaryl chloride, 95%(627-63-4)
反丁烯二酰氯价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 L0304602 Lancaster 25g 449元 2011/04/16 F0152 富马酰氯 Fumaryl Chloride 25G 330元 2011/04/16 F0152 富马酰氯 Fumaryl Chloride 500G 3380元
MSDS 信息:丁烯二酰氯(反式)(627-63-4).msds
Alfa Aesar:富马酰氯,95% Fumaryl chloride, 95%(627-63-4)
外观性质:无色至浅黄色液体。
Sigma Aldrich:627-63-4(sigmaaldrich)
MOL 文件:627-63-4.mol
方法一:由顺丁烯二酸酐与邻苯二甲酰氯在氯化锌存在下反应而得。将顺丁烯二酸酐、工业邻苯二甲氯和无水氯化锌在130-135℃加热2h，注意避免过热。然后冷却到90-95℃，迅速进行蒸馏，收集62-64（1.73kPa）馏分即为反丁烯二酰氯，收率90%左右。此外，由外，由反丁烯二酸与邻苯二甲酰氯或亚硫酰氯或五氯化磷反应也可制得反丁烯二酰氯。
海关编码:29171990
上游原料:氧氯化硫 --> 五氯化磷 --> 氯化锌 --> 马来酸酐 --> 富马酸 --> 邻苯二甲酰氯
敏感性:Moisture Sensitive
TCI Shanghai:富马酰氯 Fumaryl Chloride,>;95.0%(GC)(T)(627-63-4)