CAS 106-46-7 MFCD00000604-1,4-Dichlorobenzene 1,4-二氯苯 TAO{mole}

1,4-Dichlorobenzene 1,4-二氯苯

CAS 106-46-7 MFCD00000604

化学结构图

SMILES: Clc1ccc(Cl)cc1

化学属性

Mol. Formula	C6H4Cl2
Mol. Weight	147.004
Density	1.24
Flash Point	65.56°C
TSCA	Yes
Melting Point	52-54 °C
Boiling Point	173 °C at 760 mmHg
Vapor Density	5.07 (vs air)
Vapor Pressure	1.03 mmHg ( 25 °C)
Solubility	不溶于水，溶于乙醇、乙醚、苯。
Refractive index	1.5285

别名和识别编码

Chemical Name	1,4-Dichlorobenzene
MDL Number	MFCD00000604
CAS Number	106-46-7
Synonym	1,4-Dichlorobenzene {LY} 1,4-Dichlorobenzene {} {LY} 1,4-Dichlorobenzene {} {} {LY} 1,4-Dichlorobenzene {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 1,4-Dichlorobenzene {} {} {} {} {} {} {} {} {} {} {}
EC Number	203-400-5
Merck Number	3057
Beilstein Registry Number	5,203
PubChem Substance ID	87567327
Chemical Name Translation	1,4-二氯苯
Reaxys-RN	1680023
Wiswesser Line Notation	GR DG
LabNetwork Molecule ID	LN00199543
InChI	InChI=1S/C6H4Cl2/c7-5-1-2-6(8)4-3-5/h1-4H
Canonical SMILES	ClC1=CC=C(Cl)C=C1

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产品应用

用作杀虫剂熏蒸剂、防蛀剂、除臭剂、防腐剂、分析试剂及用于有机合成。

安全信息

RTECSCZ4550000

Safety Statements

S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Packing GroupIII

UN Number 3077 UN 3077 9/PG 3 UN3077

Risk Statements

R36 Irritating to eyes 刺激眼睛
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R50/53

GHS Symbol

WGK Germany2

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H303 May be harmfully swallowed 吞食可能有害
H319 Causes serious eye irritation 严重刺激眼睛
H351 Suspected of causing cancer 怀疑致癌
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P302+P352+P333+P313+P362+P364
P303+P361+P353
P305+P351+P338
P305+P351+P338+P337+P313
P308+P311
P337+P313
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Hazard Codes

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard Class9

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 155 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-319,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 155 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-319,1987

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human
DOSE/DURATION           : 357 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 31,1499,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   7,299,1986

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 857 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,210,1969

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 37 gm/m3/30M
TOXIC EFFECTS :
   Behavioral - general anesthetic
REFERENCE :
   YKYUA6 Yakkyoku.  Pharmacy.  (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
   Japan)  V.1-    1950-  Volume(issue)/page/year: 38,1045,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 800 mg/kg
REFERENCE :
   ACDSEL Advances in Contraceptive Delivery Systems.  (Reproductive Health
   Center, 78 Surfsong Rd., Kiawah Island, SC 29455)  V.1-    1985-
   Volume(issue)/page/year: 2,248,1985

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 355 mg/kg/24H
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,111,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 200 mg/L
REFERENCE :
   CJMIAZ Canadian Journal of Microbiology.  (National Research Council of
   Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 
     1954-  Volume(issue)/page/year: 16,369,1970

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 100 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 263,57,1991

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 343,157,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 37,164,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7500 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   BECTA6 Bulletin of Environmental Contamination and Toxicology.
   (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
   07094)  V.1-    1966-  Volume(issue)/page/year: 37,164,1986

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 800 ppm/6H
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   5,190,1985

其他信息

1,4-二氯苯价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 80046128 1，4-二氯苯;对二氯苯 500g 36.5元 2011/04/16 S0666 1,4二氯苯(1mg/ml的甲醇溶液)[用于水分析] 1,4-Dichlorobenzene (1mg/ml in Methanol) [for Water Analysis] 1ML 198元 2010/06/21 113190025 1,4-二氯苯 1,4-Dichlorobenzene 99+% 2.5 KG 776元
灭火剂:水、二氧化碳、泡沫、1211灭火剂
毒性分级:中毒
图谱信息:1,4-二氯苯(106-46-7)红外图谱(IR3) 1,4-二氯苯(106-46-7)核磁图( 13 CNMR) 1,4-二氯苯(106-46-7)红外图谱(IR1) 1,4-二氯苯(106-46-7)Raman光谱 1,4-二氯苯(106-4
用途三:对二氯苯是杀虫剂杀螟威，除草剂麦草畏、喹禾灵的中间体，也是染料和医药中间体，并可作为家庭用杀虫剂和防蛀剂。
刺激数据:眼- 人 80 PPM
方法二:苯定向氯化或从氯苯生产中回收。1.苯定向氯化将苯置于氯化反应器中，加苯重量的0.1%-0.6%的硫化锑，通入氯气，控制氯化温度在20℃左右，氯化30-45分钟，加入苯磺酸定向催化剂，然后再通入氯气，当二氯苯晶体析出时，将反应液加热到50-60℃，再缓速通氯气直到反应液增重理论量的95%左右为止，收率70%-75%。由于苯氯化产物组分较多，工业制备的关键是对二氯苯选择适当的分离，精制方法。分离和精制对、邻位二氯苯的方法较多。精馏法较结晶法难度大、能耗高，不利于产物的稳定和设备的防腐蚀。重结晶法已发展到连续分级结晶法。乳化法利用表面活性物质进行乳化而分离，此法具有操作简单，能耗低，效率高和环境污染少
蒸气压:1.03 mm Hg ( 25 °C)
用途四:有机合成原料，用于合成染料（大红色基GG以及红色基3GL、活性嫩黄和红色RC）及农药中间体，用作熏蒸杀虫剂、织物防蛀剂、防霉剂、空气脱臭剂，65%-70%用于制造卫生球，少量用于特压润滑剂，腐蚀抑制剂。该品也用于医药，也可作溶剂。
储运特性:库房通风低温干燥; 与氧化剂分开存放
蒸气密度:5.07 (vs air)
上游原料:苯 --> 氯 --> 邻二氯苯 --> 1,3-二氯苯 --> 对二氯苯 --> 锑 --> 混合二氯苯 --> 邻位二氯苯 --> 高效填料塔
TCI Shanghai:1,4二氯苯(1mg/ml的甲醇溶液)[用于水分析] 1,4-Dichlorobenzene (1mg/ml in Methanol) [for Water Analysis](106-46-7)
可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产生有毒氯化物烟雾
防护措施:本品具有中等毒性，刺激眼睛和粘膜。
Alfa Aesar:1,4-二氯苯,99+% 1,4-Dichlorobenzene, 99+%(106-46-7)
方法一:其制备方法有以下几种。苯定向氯化将苯置于氯化反应器中，加入催化剂硫化锑(Sb 2 S)，开始通入氯气，控制氯化温度在20℃左右，氯化30～45min后，加入苯磺酸定向催化剂，然后再通入氯气，当二氯苯晶体析出时，将反应液加热到50～60℃，再缓慢通氯气，直到反应液增重到理论量的95％左右为止，然后经后处理，过滤、干燥得产品。反应方程式图：氯苯进一步氯化以氯苯为原料与氯气反应，在特定的催化剂作用下定向氯化生产二氯苯(含对、邻二氯苯和少量间二氯苯)，结合高效填料塔精馏和立式结晶器进行结晶的方法，分别得到高纯度的对、邻和间二氯
用途一:用作有机分析试剂、溶剂和杀虫、防蛀剂
{C
图谱信息:1,4-二氯苯(106-46-7)红外图谱(IR
用途五:用作杀虫剂熏蒸剂、防蛀剂、除臭剂、防腐剂、分析试剂及用于有机合成。